Renal perfusion changes during treatment of essential hypertension

prazosin versus propranolol.

D. T. O'Connor, Richard A Preston, E. H. Sasso

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

To evaluate renal hemodynamic changes during therapy of essential hypertension, we treated 12 essential hypertensives in crossover fashion, with 1 month each of placebo, prazosin, and propranolol alone. During prazosin treatment, blood pressure was normalized with preservation of glomerular filtration rate, renal plasma flow, and renal blood flow. Propranolol, however, normalized blood pressure with an associated significant decline in glomerular filtration rate, renal plasma flow, and renal blood flow. The potential mechanisms are discussed.

Original languageEnglish
JournalJournal of Cardiovascular Pharmacology
Volume1
Issue number6 Suppl
StatePublished - Nov 1 1979
Externally publishedYes

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Renal Plasma Flow
Prazosin
Renal Circulation
Glomerular Filtration Rate
Propranolol
Perfusion
Blood Pressure
Kidney
Hemodynamics
Placebos
Therapeutics
Essential Hypertension

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pharmacology

Cite this

Renal perfusion changes during treatment of essential hypertension : prazosin versus propranolol. / O'Connor, D. T.; Preston, Richard A; Sasso, E. H.

In: Journal of Cardiovascular Pharmacology, Vol. 1, No. 6 Suppl, 01.11.1979.

Research output: Contribution to journalArticle

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