Renal parenchyma-sparing surgery as conservative treatment of renal cell carcinoma

Gaetano Ciancio, V. A. Politano, S. Ferrell, Norman L Block

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Objective. To evaluate the role of parenchyma-sparing surgery in patients with renal cell carcinoma (RCC). Patients and methods. Between 1965 and 1990, 34 patients with RCC underwent renal parenchyma-sparing surgery. There were 22 men and 12 women with a mean age of 62 years (range 40-89). Ten patients underwent enucleation (Group A), 15 partial nephrectomy (Group B), and nine a combination of procedures (Group C). Conservative surgery was performed in the presence of a normal contralateral unit in four patients (12%). Results. Five patients developed local recurrence. Metastases appeared in six patients (18%) from 12 to 58 months post-operatively. Adequate renal function was obtained in 32 of the 34 patients. The mean follow-up for all patients was 64.6 months overall, 75.6 months for group A, 64.1 months for group B and 53.4 months for group C. The 3 and 5 year probabilities of survival for all patients were 77.8% and 69.5% respectively. The probabilities of 3 and 5 year survival were 80% for group A, 80% for group B and 71.4% and 57.1% for group C. Conclusion. Enucleation and partial nephrectomy are both viable options in the management of solitary or bilateral RCC, as there is no decline in effective tumour control and prognosis. Larger groups and longer follow-ups are needed to assess the role of renal parenchyma-sparing surgery more definitively.

Original languageEnglish
Pages (from-to)422-430
Number of pages9
JournalBritish Journal of Urology
Volume74
Issue number4
StatePublished - Jan 1 1994

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Renal Cell Carcinoma
Kidney
Nephrectomy
Conservative Treatment
Survival
Neoplasm Metastasis
Recurrence

Keywords

  • In situ enucleation
  • Kidney cancer surgery
  • Partial nephrectomy
  • Renal cell carcinoma
  • Renal-conserving surgery

ASJC Scopus subject areas

  • Urology

Cite this

Renal parenchyma-sparing surgery as conservative treatment of renal cell carcinoma. / Ciancio, Gaetano; Politano, V. A.; Ferrell, S.; Block, Norman L.

In: British Journal of Urology, Vol. 74, No. 4, 01.01.1994, p. 422-430.

Research output: Contribution to journalArticle

Ciancio, G, Politano, VA, Ferrell, S & Block, NL 1994, 'Renal parenchyma-sparing surgery as conservative treatment of renal cell carcinoma', British Journal of Urology, vol. 74, no. 4, pp. 422-430.
Ciancio, Gaetano ; Politano, V. A. ; Ferrell, S. ; Block, Norman L. / Renal parenchyma-sparing surgery as conservative treatment of renal cell carcinoma. In: British Journal of Urology. 1994 ; Vol. 74, No. 4. pp. 422-430.
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abstract = "Objective. To evaluate the role of parenchyma-sparing surgery in patients with renal cell carcinoma (RCC). Patients and methods. Between 1965 and 1990, 34 patients with RCC underwent renal parenchyma-sparing surgery. There were 22 men and 12 women with a mean age of 62 years (range 40-89). Ten patients underwent enucleation (Group A), 15 partial nephrectomy (Group B), and nine a combination of procedures (Group C). Conservative surgery was performed in the presence of a normal contralateral unit in four patients (12{\%}). Results. Five patients developed local recurrence. Metastases appeared in six patients (18{\%}) from 12 to 58 months post-operatively. Adequate renal function was obtained in 32 of the 34 patients. The mean follow-up for all patients was 64.6 months overall, 75.6 months for group A, 64.1 months for group B and 53.4 months for group C. The 3 and 5 year probabilities of survival for all patients were 77.8{\%} and 69.5{\%} respectively. The probabilities of 3 and 5 year survival were 80{\%} for group A, 80{\%} for group B and 71.4{\%} and 57.1{\%} for group C. Conclusion. Enucleation and partial nephrectomy are both viable options in the management of solitary or bilateral RCC, as there is no decline in effective tumour control and prognosis. Larger groups and longer follow-ups are needed to assess the role of renal parenchyma-sparing surgery more definitively.",
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