Renal medullary carcinoma and sickle cell trait: A systematic review

Ofelia A Alvarez, Maria Rodriguez, Lanetta B Jordan, Sharada Sarnaik

Research output: Contribution to journalArticlepeer-review

35 Scopus citations

Abstract

Sickle cell trait (SCT) carries a small risk of renal medullary carcinoma (RMC). We conducted a systematic literature review and reported new four RMC cases (total N=217). Eighty eight percent had SCT and 8% had sickle cell disease; 50% were children. Males had 2.4× risk than females. Isolated hematuria or in combination with abdominal or flank pain was the presenting sign in 66% cases. Tumor-related mortality was 95%. Four non-metastatic patients were long-term disease-free survivors. Although risk appears to be very low, individuals with SCT should be informed about the low risk of RMC with the hope of early diagnosis. Hematuria should prompt immediate investigation.

Original languageEnglish (US)
Pages (from-to)1694-1699
Number of pages6
JournalPediatric Blood and Cancer
Volume62
Issue number10
DOIs
StatePublished - Oct 1 2015

Keywords

  • Cancer
  • Rare tumors
  • Renal
  • Sickle cell disease
  • Sickle cell trait
  • Tumors

ASJC Scopus subject areas

  • Oncology
  • Pediatrics, Perinatology, and Child Health
  • Hematology

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