Renal Involvement in Essential Mixed Cryoglobulinemia

Guido O. Perez, Victoriano Pardo, Mary Ann Fletcher

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Essential mixed cryoglobulinemia (EMC) is infrequently recognized in this country. We report studies performed in six patients with EMC evaluated by us over the last 6 years. Purpura was present in three patients and glomerulonephritis in all. Two patients had chronic hepatitis B infection. Positive cryoglobulins and C1q binding, hypocomplementemia (especially low C4), positive rheumatoid factor titer, and negative anti-DNA antibodies were characteristic laboratory findings. The cryoprecipitate had strongly positive rheumatoid factor activity and contained a monoclonal IgM, kappa type in one of the two patients evaluated. The predominant lesion by renal biopsy was mesangiocapillary glomerulonephritis type I; electron microscopy revealed typical fibrillar structures in four cases. The above-mentioned features help distinguish EMC from other forms of glomerulonephritis.

Original languageEnglish (US)
Pages (from-to)276-280
Number of pages5
JournalAmerican Journal of Kidney Diseases
Issue number4
StatePublished - Jan 1 1987


  • Cryoglobulins
  • fibrillar renal deposits
  • glomerulonephritis
  • hepatitis B infection
  • mesangiocapillary glomerulonephritis
  • purpura

ASJC Scopus subject areas

  • Nephrology


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