Renal Function After Pediatric Intestinal Transplant

T. Ueno, T. Kato, Jeffrey Gaynor, M. Velasco, Gennaro Selvaggi, Gaston E Zilleruelo, Gwenn E McLaughlin, E. Hernandez, J. Thompson, A. Tzakis

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Data were analyzed from 44 patients who survived more than 2 years after intestinal transplantation performed between 1994 and 2002. Median age was 1.7 years. Tacrolimus level was defined as average tacrolimus level over 6 months. Kidney function was evaluated using a 6-month average serum creatinine. Glomerular filtration rate (GFR) was calculated with the Schwartz formula. The procedures were: isolated intestinal transplantation (n = 11), liver and intestinal transplantation (n = 9), multivisceral transplantation (n = 22), and modified multivisceral transplantation (n = 2). Forty-four patients were followed for a mean of 3.6 years on tacrolimus. Tacrolimus levels ranged between 3.5 and 19.9 ng/mL (median 14.6 ng/mL) at 0 to 6 months and 6.0 to 18.9 ng/mL (median 13.2 ng/mL) at 0 to 12 months. Pretransplant kidney function as mean GFR was 138 ± 42 mL/min/1.73 m2 (n = 44), posttransplant kidney function at 18 to 24 month as mean GFR was 102 ± 35 mL/min/1.73 m2 (n = 44), a value that was 81% of the pretransplant GFR (P < .0001). In an analysis of tacrolimus level versus renal function, a value greater than 13.5 ng/mL during the first 12 months was a significant predictor for impaired renal function at 2 years after transplantation (defined as average GFR less than 90 mL/min/1.73 m2 at 18 to 24 months; P = .001). Only age among age, sex, diagnosis, transplant type, and rejection episodes showed a correlation with renal function. Renal function dropped significantly at 2 years after pediatric intestinal transplantation to 81% of the pretransplantation value. Tacrolimus level for the first 12 months seemed to predict subsequent development of renal impairment at 2 years.

Original languageEnglish
Pages (from-to)1759-1761
Number of pages3
JournalTransplantation Proceedings
Volume38
Issue number6
DOIs
StatePublished - Jul 1 2006

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Tacrolimus
Pediatrics
Transplants
Kidney
Glomerular Filtration Rate
Transplantation
Graft Rejection
Liver Transplantation
Creatinine
Serum

ASJC Scopus subject areas

  • Surgery
  • Transplantation

Cite this

Renal Function After Pediatric Intestinal Transplant. / Ueno, T.; Kato, T.; Gaynor, Jeffrey; Velasco, M.; Selvaggi, Gennaro; Zilleruelo, Gaston E; McLaughlin, Gwenn E; Hernandez, E.; Thompson, J.; Tzakis, A.

In: Transplantation Proceedings, Vol. 38, No. 6, 01.07.2006, p. 1759-1761.

Research output: Contribution to journalArticle

Ueno, T, Kato, T, Gaynor, J, Velasco, M, Selvaggi, G, Zilleruelo, GE, McLaughlin, GE, Hernandez, E, Thompson, J & Tzakis, A 2006, 'Renal Function After Pediatric Intestinal Transplant', Transplantation Proceedings, vol. 38, no. 6, pp. 1759-1761. https://doi.org/10.1016/j.transproceed.2006.05.026
Ueno, T. ; Kato, T. ; Gaynor, Jeffrey ; Velasco, M. ; Selvaggi, Gennaro ; Zilleruelo, Gaston E ; McLaughlin, Gwenn E ; Hernandez, E. ; Thompson, J. ; Tzakis, A. / Renal Function After Pediatric Intestinal Transplant. In: Transplantation Proceedings. 2006 ; Vol. 38, No. 6. pp. 1759-1761.
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AU - Zilleruelo, Gaston E

AU - McLaughlin, Gwenn E

AU - Hernandez, E.

AU - Thompson, J.

AU - Tzakis, A.

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