Renal cell carcinoma with inferior vena cava involvement: Prognostic effect of tumor thrombus consistency on cancer specific survival

On behalf of the International Renal Cell Carcinoma-Venous Thrombus Consortium

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Background: Renal cell carcinoma forming a venous tumor thrombus (VTT) in the inferior vena cava (IVC) has a poor prognosis. Recent investigations have been focused on prognostic markers of survival. Thrombus consistency (TC) has been proposed to be of significant value but yet there are conflicting data. The aim of this study is to test the effect of IVC VTT consistency on cancer specific survival (CSS) in a multi-institutional cohort. Methods: The records of 413 patients collected by the International Renal Cell Carcinoma–Venous Thrombus Consortium were retrospectively analyzed. All patients underwent radical nephrectomy and tumor thrombectomy. Kaplan–Meier estimate and Cox regression analyses investigated the impact of TC on CSS in addition to established clinicopathological predictors. Results: VTT was solid in 225 patients and friable in 188 patients. Median CSS was 50 months in solid and 45 months in friable VTT. TC showed no significant association with metastatic spread, pT stage, perinephric fat invasion, and higher Fuhrman grade. Survival analysis and Cox regression rejected TC as prognostic marker for CSS. Conclusions: In the largest cohort published so far, TC seems not to be independently associated with survival in RCC patients and should therefore not be included in risk stratification models. J. Surg. Oncol. 2016;114:764–768.

Original languageEnglish (US)
Pages (from-to)764-768
Number of pages5
JournalJournal of Surgical Oncology
Volume114
Issue number6
DOIs
StatePublished - Nov 1 2016

Fingerprint

Inferior Vena Cava
Renal Cell Carcinoma
Thrombosis
Survival
Neoplasms
Thrombectomy
Survival Analysis
Nephrectomy
Fats
Regression Analysis
Kidney

Keywords

  • cancer specific survival
  • renal cell carcinoma
  • thrombus consistency
  • venous tumor thrombus

ASJC Scopus subject areas

  • Surgery
  • Oncology

Cite this

Renal cell carcinoma with inferior vena cava involvement : Prognostic effect of tumor thrombus consistency on cancer specific survival. / On behalf of the International Renal Cell Carcinoma-Venous Thrombus Consortium.

In: Journal of Surgical Oncology, Vol. 114, No. 6, 01.11.2016, p. 764-768.

Research output: Contribution to journalArticle

On behalf of the International Renal Cell Carcinoma-Venous Thrombus Consortium. / Renal cell carcinoma with inferior vena cava involvement : Prognostic effect of tumor thrombus consistency on cancer specific survival. In: Journal of Surgical Oncology. 2016 ; Vol. 114, No. 6. pp. 764-768.
@article{3a88424572d04f0ea1dab732c6a638e0,
title = "Renal cell carcinoma with inferior vena cava involvement: Prognostic effect of tumor thrombus consistency on cancer specific survival",
abstract = "Background: Renal cell carcinoma forming a venous tumor thrombus (VTT) in the inferior vena cava (IVC) has a poor prognosis. Recent investigations have been focused on prognostic markers of survival. Thrombus consistency (TC) has been proposed to be of significant value but yet there are conflicting data. The aim of this study is to test the effect of IVC VTT consistency on cancer specific survival (CSS) in a multi-institutional cohort. Methods: The records of 413 patients collected by the International Renal Cell Carcinoma–Venous Thrombus Consortium were retrospectively analyzed. All patients underwent radical nephrectomy and tumor thrombectomy. Kaplan–Meier estimate and Cox regression analyses investigated the impact of TC on CSS in addition to established clinicopathological predictors. Results: VTT was solid in 225 patients and friable in 188 patients. Median CSS was 50 months in solid and 45 months in friable VTT. TC showed no significant association with metastatic spread, pT stage, perinephric fat invasion, and higher Fuhrman grade. Survival analysis and Cox regression rejected TC as prognostic marker for CSS. Conclusions: In the largest cohort published so far, TC seems not to be independently associated with survival in RCC patients and should therefore not be included in risk stratification models. J. Surg. Oncol. 2016;114:764–768.",
keywords = "cancer specific survival, renal cell carcinoma, thrombus consistency, venous tumor thrombus",
author = "{On behalf of the International Renal Cell Carcinoma-Venous Thrombus Consortium} and Rene Mager and Siamak Daneshmand and Evans, {Christopher P.} and Joan Palou and Mart{\'i}nez-Salamanca, {Juan I.} and Master, {Viraj A.} and McKiernan, {James M.} and Libertino, {John A.} and Axel Haferkamp and Axel Haferkamp and Umberto Capitanio and Carballido, {Joaqu{\'i}n A.} and Venancio Chantada and Thomas Chromecki and Gaetano Ciancio and Gaetano Ciancio and Evans, {Christopher P.} and Paolo Gontero and Javier Gonz{\'a}lez and Markus Hohenfellner and Huang, {William C.} and Koppie, {Theresa M.} and Libertino, {John A.} and Espin{\'o}s, {Estefan{\'i}a Linares} and Adam Lorentz and Mart{\'i}nez-Salamanca, {Juan I.} and Master, {Viraj A.} and McKiernan, {James M.} and Francesco Montorsi and Giacomo Novara and Padraic O'Malley and Sascha Pahernik and Joan Palou and Moreno, {Jos{\'e} Luis Pontones} and Pruthi, {Raj S.} and Faba, {Oscar Rodriguez} and Paul Russo and Scherr, {Douglas S.} and Shariat, {Shahrokh F.} and Martin Spahn and Carlo Terrone and Derya Tilki and Dario V{\'a}zquez-Martul and Donoso, {Cesar Vera} and Daniel Vergho and Wallen, {Eric M.} and Richard Zigeuner",
year = "2016",
month = "11",
day = "1",
doi = "10.1002/jso.24395",
language = "English (US)",
volume = "114",
pages = "764--768",
journal = "Journal of Surgical Oncology",
issn = "0022-4790",
publisher = "Wiley-Liss Inc.",
number = "6",

}

TY - JOUR

T1 - Renal cell carcinoma with inferior vena cava involvement

T2 - Prognostic effect of tumor thrombus consistency on cancer specific survival

AU - On behalf of the International Renal Cell Carcinoma-Venous Thrombus Consortium

AU - Mager, Rene

AU - Daneshmand, Siamak

AU - Evans, Christopher P.

AU - Palou, Joan

AU - Martínez-Salamanca, Juan I.

AU - Master, Viraj A.

AU - McKiernan, James M.

AU - Libertino, John A.

AU - Haferkamp, Axel

AU - Haferkamp, Axel

AU - Capitanio, Umberto

AU - Carballido, Joaquín A.

AU - Chantada, Venancio

AU - Chromecki, Thomas

AU - Ciancio, Gaetano

AU - Ciancio, Gaetano

AU - Evans, Christopher P.

AU - Gontero, Paolo

AU - González, Javier

AU - Hohenfellner, Markus

AU - Huang, William C.

AU - Koppie, Theresa M.

AU - Libertino, John A.

AU - Espinós, Estefanía Linares

AU - Lorentz, Adam

AU - Martínez-Salamanca, Juan I.

AU - Master, Viraj A.

AU - McKiernan, James M.

AU - Montorsi, Francesco

AU - Novara, Giacomo

AU - O'Malley, Padraic

AU - Pahernik, Sascha

AU - Palou, Joan

AU - Moreno, José Luis Pontones

AU - Pruthi, Raj S.

AU - Faba, Oscar Rodriguez

AU - Russo, Paul

AU - Scherr, Douglas S.

AU - Shariat, Shahrokh F.

AU - Spahn, Martin

AU - Terrone, Carlo

AU - Tilki, Derya

AU - Vázquez-Martul, Dario

AU - Donoso, Cesar Vera

AU - Vergho, Daniel

AU - Wallen, Eric M.

AU - Zigeuner, Richard

PY - 2016/11/1

Y1 - 2016/11/1

N2 - Background: Renal cell carcinoma forming a venous tumor thrombus (VTT) in the inferior vena cava (IVC) has a poor prognosis. Recent investigations have been focused on prognostic markers of survival. Thrombus consistency (TC) has been proposed to be of significant value but yet there are conflicting data. The aim of this study is to test the effect of IVC VTT consistency on cancer specific survival (CSS) in a multi-institutional cohort. Methods: The records of 413 patients collected by the International Renal Cell Carcinoma–Venous Thrombus Consortium were retrospectively analyzed. All patients underwent radical nephrectomy and tumor thrombectomy. Kaplan–Meier estimate and Cox regression analyses investigated the impact of TC on CSS in addition to established clinicopathological predictors. Results: VTT was solid in 225 patients and friable in 188 patients. Median CSS was 50 months in solid and 45 months in friable VTT. TC showed no significant association with metastatic spread, pT stage, perinephric fat invasion, and higher Fuhrman grade. Survival analysis and Cox regression rejected TC as prognostic marker for CSS. Conclusions: In the largest cohort published so far, TC seems not to be independently associated with survival in RCC patients and should therefore not be included in risk stratification models. J. Surg. Oncol. 2016;114:764–768.

AB - Background: Renal cell carcinoma forming a venous tumor thrombus (VTT) in the inferior vena cava (IVC) has a poor prognosis. Recent investigations have been focused on prognostic markers of survival. Thrombus consistency (TC) has been proposed to be of significant value but yet there are conflicting data. The aim of this study is to test the effect of IVC VTT consistency on cancer specific survival (CSS) in a multi-institutional cohort. Methods: The records of 413 patients collected by the International Renal Cell Carcinoma–Venous Thrombus Consortium were retrospectively analyzed. All patients underwent radical nephrectomy and tumor thrombectomy. Kaplan–Meier estimate and Cox regression analyses investigated the impact of TC on CSS in addition to established clinicopathological predictors. Results: VTT was solid in 225 patients and friable in 188 patients. Median CSS was 50 months in solid and 45 months in friable VTT. TC showed no significant association with metastatic spread, pT stage, perinephric fat invasion, and higher Fuhrman grade. Survival analysis and Cox regression rejected TC as prognostic marker for CSS. Conclusions: In the largest cohort published so far, TC seems not to be independently associated with survival in RCC patients and should therefore not be included in risk stratification models. J. Surg. Oncol. 2016;114:764–768.

KW - cancer specific survival

KW - renal cell carcinoma

KW - thrombus consistency

KW - venous tumor thrombus

UR - http://www.scopus.com/inward/record.url?scp=84992463366&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84992463366&partnerID=8YFLogxK

U2 - 10.1002/jso.24395

DO - 10.1002/jso.24395

M3 - Article

C2 - 27562252

AN - SCOPUS:84992463366

VL - 114

SP - 764

EP - 768

JO - Journal of Surgical Oncology

JF - Journal of Surgical Oncology

SN - 0022-4790

IS - 6

ER -