Renal cancer: Molecular mechanisms and newer therapeutic options

S. Ananth Karumanchi, Jaime Merchan, Vikas P. Sukhatme

Research output: Contribution to journalReview articlepeer-review

84 Scopus citations


Renal cell carcinomas account for 80-85% of all primary renal neoplasms. Recent identification of VHL, c-met and TSC as candidate genes mutated in various types of renal carcinomas has greatly enhanced our understanding of the pathogenesis of renal carcinomas and has provided novel therapeutic options for patients with renal cancer. Furthermore, developments in angiogenesis and in tumor immunology have given us additional treatment modalities for cancer patients, especially those with renal cancer. This review highlights the genetic abnormalities seen in renal cell carcinomas and reviews current and future therapeutic options.

Original languageEnglish (US)
Pages (from-to)37-42
Number of pages6
JournalCurrent Opinion in Nephrology and Hypertension
Issue number1
StatePublished - Jan 21 2002
Externally publishedYes

ASJC Scopus subject areas

  • Internal Medicine
  • Nephrology


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