Renal bicarbonate handling in low birth weight infants during metabolic acidosis

Gaston E Zilleruelo, S. Sultan, Eduardo Bancalari, Bernard W Steele, J. Strauss

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

We studied the fractional excretion of bicarbonate (FE HCO3-) in 10 low birth weight infants aged 1-6 days during metabolic acidosis (base excess ≥ -5 mEq/1) and during subsequent sodium HCO3- infusion. The mean birth weight was 1,095 g; the mean gestational age was 29 weeks. The ability to decrease urine pH to >5.5 and FE HCO3- to >1% during metabolic acidosis was not limited by low gestational age or birth weight. After HCO3- therapy, all infants corrected their negative base excess, and plasma HCO3- increased significantly. All infants with blood pH ≥7.22 or PaCO2 ≥ 50 mm Hg had minimal or absent FE HCO3-. Infants with elevated PaCO2 and mild or absent acidosis also had complete HCO3- tubular reabsorption. These results suggest that the HCO3- tubular reabsorption is adequate during metabolic and/or respiratory acidosis in low birth weight infants.

Original languageEnglish
Pages (from-to)132-139
Number of pages8
JournalBiology of the Neonate
Volume49
Issue number3
StatePublished - Jul 30 1986

Fingerprint

Low Birth Weight Infant
Bicarbonates
Acidosis
Kidney
Birth Weight
Gestational Age
Respiratory Acidosis
Sodium
Urine
Therapeutics

ASJC Scopus subject areas

  • Developmental Biology
  • Pediatrics, Perinatology, and Child Health

Cite this

Zilleruelo, G. E., Sultan, S., Bancalari, E., Steele, B. W., & Strauss, J. (1986). Renal bicarbonate handling in low birth weight infants during metabolic acidosis. Biology of the Neonate, 49(3), 132-139.

Renal bicarbonate handling in low birth weight infants during metabolic acidosis. / Zilleruelo, Gaston E; Sultan, S.; Bancalari, Eduardo; Steele, Bernard W; Strauss, J.

In: Biology of the Neonate, Vol. 49, No. 3, 30.07.1986, p. 132-139.

Research output: Contribution to journalArticle

Zilleruelo, GE, Sultan, S, Bancalari, E, Steele, BW & Strauss, J 1986, 'Renal bicarbonate handling in low birth weight infants during metabolic acidosis', Biology of the Neonate, vol. 49, no. 3, pp. 132-139.
Zilleruelo GE, Sultan S, Bancalari E, Steele BW, Strauss J. Renal bicarbonate handling in low birth weight infants during metabolic acidosis. Biology of the Neonate. 1986 Jul 30;49(3):132-139.
Zilleruelo, Gaston E ; Sultan, S. ; Bancalari, Eduardo ; Steele, Bernard W ; Strauss, J. / Renal bicarbonate handling in low birth weight infants during metabolic acidosis. In: Biology of the Neonate. 1986 ; Vol. 49, No. 3. pp. 132-139.
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