Abstract
Background - To assess the reliability of pediatric echocardiographic measurements, we compared local measurements with those made at a central facility. Methods and Results - The comparison was based on the first echocardiographic recording obtained on 735 children of HIV-infected mothers at 10 clinical sites focusing on measurements of left ventricular (LV) dimension, wall thicknesses, and fractional shortening. The recordings were measured locally and then remeasured at a central facility. The highest agreement expressed as an intraclass correlation coefficient (ICC=0.97) was noted for LV dimension, with much lower agreement for posterior wall thickness (ICC=0.65), fractional shortening (ICC=0.64), and septal wall thickness (ICC=0.50). The mean dimension was 0.03 cm smaller in central measurements (95% prediction interval [PI], -0.32 to 0.25 cm) for which 95% PI reflects the magnitude of differences between local and central measurements. Mean posterior wall thickness was 0.02 cm larger in central measurements (95% PI, -0.18 to 0.22 cm). Mean fractional shortening was 1% smaller in central measurements. However, the 95% PI was - 10% to 8%, indicating that a fractional shortening of 32% measured centrally could be anywhere between 22% and 40% when measured locally. Central measurements of mean septal thickness were ≈0.1 cm thicker than local ones (95% PI, -0.18 to 0.34 cm). Centrally measured wall thickness was more closely related to mortality and possibly was more valid than local measurements. Conclusions - Although LV dimension was reliably measured, local measurements of LV wall thickness and fractional shortening differed from central measurements.
| Original language | English |
|---|---|
| Pages (from-to) | 310-316 |
| Number of pages | 7 |
| Journal | Circulation |
| Volume | 104 |
| Issue number | 3 |
| State | Published - Jul 17 2001 |
| Externally published | Yes |
Fingerprint
Keywords
- AIDS
- Echocardiography
- Pediatrics
ASJC Scopus subject areas
- Physiology
- Cardiology and Cardiovascular Medicine
Cite this
Reliability of multicenter pediatric echocardiographic measurements of left ventricular structure and function : The prospective P 2C 2 HIV study. / Lipshultz, Steven E; Easley, Kirk A.; Orav, E. John; Kaplan, Samuel; Starc, Thomas J.; Bricker, J. Timothy; Lai, Wyman W.; Moodie, Douglas S.; Sopko, George; Schluchter, Mark D.; Colan, Steven D.
In: Circulation, Vol. 104, No. 3, 17.07.2001, p. 310-316.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Reliability of multicenter pediatric echocardiographic measurements of left ventricular structure and function
T2 - The prospective P 2C 2 HIV study
AU - Lipshultz, Steven E
AU - Easley, Kirk A.
AU - Orav, E. John
AU - Kaplan, Samuel
AU - Starc, Thomas J.
AU - Bricker, J. Timothy
AU - Lai, Wyman W.
AU - Moodie, Douglas S.
AU - Sopko, George
AU - Schluchter, Mark D.
AU - Colan, Steven D.
PY - 2001/7/17
Y1 - 2001/7/17
N2 - Background - To assess the reliability of pediatric echocardiographic measurements, we compared local measurements with those made at a central facility. Methods and Results - The comparison was based on the first echocardiographic recording obtained on 735 children of HIV-infected mothers at 10 clinical sites focusing on measurements of left ventricular (LV) dimension, wall thicknesses, and fractional shortening. The recordings were measured locally and then remeasured at a central facility. The highest agreement expressed as an intraclass correlation coefficient (ICC=0.97) was noted for LV dimension, with much lower agreement for posterior wall thickness (ICC=0.65), fractional shortening (ICC=0.64), and septal wall thickness (ICC=0.50). The mean dimension was 0.03 cm smaller in central measurements (95% prediction interval [PI], -0.32 to 0.25 cm) for which 95% PI reflects the magnitude of differences between local and central measurements. Mean posterior wall thickness was 0.02 cm larger in central measurements (95% PI, -0.18 to 0.22 cm). Mean fractional shortening was 1% smaller in central measurements. However, the 95% PI was - 10% to 8%, indicating that a fractional shortening of 32% measured centrally could be anywhere between 22% and 40% when measured locally. Central measurements of mean septal thickness were ≈0.1 cm thicker than local ones (95% PI, -0.18 to 0.34 cm). Centrally measured wall thickness was more closely related to mortality and possibly was more valid than local measurements. Conclusions - Although LV dimension was reliably measured, local measurements of LV wall thickness and fractional shortening differed from central measurements.
AB - Background - To assess the reliability of pediatric echocardiographic measurements, we compared local measurements with those made at a central facility. Methods and Results - The comparison was based on the first echocardiographic recording obtained on 735 children of HIV-infected mothers at 10 clinical sites focusing on measurements of left ventricular (LV) dimension, wall thicknesses, and fractional shortening. The recordings were measured locally and then remeasured at a central facility. The highest agreement expressed as an intraclass correlation coefficient (ICC=0.97) was noted for LV dimension, with much lower agreement for posterior wall thickness (ICC=0.65), fractional shortening (ICC=0.64), and septal wall thickness (ICC=0.50). The mean dimension was 0.03 cm smaller in central measurements (95% prediction interval [PI], -0.32 to 0.25 cm) for which 95% PI reflects the magnitude of differences between local and central measurements. Mean posterior wall thickness was 0.02 cm larger in central measurements (95% PI, -0.18 to 0.22 cm). Mean fractional shortening was 1% smaller in central measurements. However, the 95% PI was - 10% to 8%, indicating that a fractional shortening of 32% measured centrally could be anywhere between 22% and 40% when measured locally. Central measurements of mean septal thickness were ≈0.1 cm thicker than local ones (95% PI, -0.18 to 0.34 cm). Centrally measured wall thickness was more closely related to mortality and possibly was more valid than local measurements. Conclusions - Although LV dimension was reliably measured, local measurements of LV wall thickness and fractional shortening differed from central measurements.
KW - AIDS
KW - Echocardiography
KW - Pediatrics
UR - http://www.scopus.com/inward/record.url?scp=0035902612&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035902612&partnerID=8YFLogxK
M3 - Article
C2 - 11457750
AN - SCOPUS:0035902612
VL - 104
SP - 310
EP - 316
JO - Circulation
JF - Circulation
SN - 0009-7322
IS - 3
ER -