Abstract
We determine the reliability and reproducibility of retinal thickness measurements with a custom-built OCT retinal image analysis software (OCTRIMA). Ten eyes of five healthy subjects undergo repeated standard macular thickness map scan sessions by two experienced examiners using a Stratus OCT device. Automatic/semi automatic thickness quantification of the macula and intraretinal layers is performed using OCTRIMA software. Intraobserver, interobserver, and intervisit repeatability and reproducibility coefficients, and intraclass correlation coefficients (ICCs) per scan are calculated. Intraobserver, interobserver, and intervisit variability combined account for less than 5% of total variability for the total retinal thickness measurements and less than 7% for the intraretinal layers except the outer segment/ retinal pigment epithelium (RPE) junction. There is no significant difference between scans acquired by different observers or during different visits. The ICCs obtained for the intraobserver and intervisit variability tests are greater than 0.75 for the total retina and all intraretinal layers, except the inner nuclear layer intraobserver and interobserver test and the outer plexiform layer, intraobserver, interobserver, and intervisit test. Our results indicate that thickness measurements for the total retina and all intraretinal layers (except the outer segment/RPE junction ) performed using OCTRIMA are highly repeatable and reproducible.
| Original language | English |
|---|---|
| Article number | 064023 |
| Journal | Journal of Biomedical Optics |
| Volume | 14 |
| Issue number | 6 |
| DOIs | |
| State | Published - Dec 1 2009 |
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Keywords
- Computer-aided diagnosis
- Image analysis
- Image processing
- Optical coherence tomography
- Repeatability
- Reproducibility
- Retina
- Segmentation
ASJC Scopus subject areas
- Biomedical Engineering
- Biomaterials
- Electronic, Optical and Magnetic Materials
- Atomic and Molecular Physics, and Optics
Cite this
Reliability and reproducibility of macular segmentation using a custom-built optical coherence tomography retinal image analysis software. / Cabrera DeBuc, Delia; Somfai, Gábor Márk; Ranganathan, Sudarshan; Tátrai, Erika; Ferencz, Mária; Puliafito, Carmen A.
In: Journal of Biomedical Optics, Vol. 14, No. 6, 064023, 01.12.2009.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Reliability and reproducibility of macular segmentation using a custom-built optical coherence tomography retinal image analysis software
AU - Cabrera DeBuc, Delia
AU - Somfai, Gábor Márk
AU - Ranganathan, Sudarshan
AU - Tátrai, Erika
AU - Ferencz, Mária
AU - Puliafito, Carmen A.
PY - 2009/12/1
Y1 - 2009/12/1
N2 - We determine the reliability and reproducibility of retinal thickness measurements with a custom-built OCT retinal image analysis software (OCTRIMA). Ten eyes of five healthy subjects undergo repeated standard macular thickness map scan sessions by two experienced examiners using a Stratus OCT device. Automatic/semi automatic thickness quantification of the macula and intraretinal layers is performed using OCTRIMA software. Intraobserver, interobserver, and intervisit repeatability and reproducibility coefficients, and intraclass correlation coefficients (ICCs) per scan are calculated. Intraobserver, interobserver, and intervisit variability combined account for less than 5% of total variability for the total retinal thickness measurements and less than 7% for the intraretinal layers except the outer segment/ retinal pigment epithelium (RPE) junction. There is no significant difference between scans acquired by different observers or during different visits. The ICCs obtained for the intraobserver and intervisit variability tests are greater than 0.75 for the total retina and all intraretinal layers, except the inner nuclear layer intraobserver and interobserver test and the outer plexiform layer, intraobserver, interobserver, and intervisit test. Our results indicate that thickness measurements for the total retina and all intraretinal layers (except the outer segment/RPE junction ) performed using OCTRIMA are highly repeatable and reproducible.
AB - We determine the reliability and reproducibility of retinal thickness measurements with a custom-built OCT retinal image analysis software (OCTRIMA). Ten eyes of five healthy subjects undergo repeated standard macular thickness map scan sessions by two experienced examiners using a Stratus OCT device. Automatic/semi automatic thickness quantification of the macula and intraretinal layers is performed using OCTRIMA software. Intraobserver, interobserver, and intervisit repeatability and reproducibility coefficients, and intraclass correlation coefficients (ICCs) per scan are calculated. Intraobserver, interobserver, and intervisit variability combined account for less than 5% of total variability for the total retinal thickness measurements and less than 7% for the intraretinal layers except the outer segment/ retinal pigment epithelium (RPE) junction. There is no significant difference between scans acquired by different observers or during different visits. The ICCs obtained for the intraobserver and intervisit variability tests are greater than 0.75 for the total retina and all intraretinal layers, except the inner nuclear layer intraobserver and interobserver test and the outer plexiform layer, intraobserver, interobserver, and intervisit test. Our results indicate that thickness measurements for the total retina and all intraretinal layers (except the outer segment/RPE junction ) performed using OCTRIMA are highly repeatable and reproducible.
KW - Computer-aided diagnosis
KW - Image analysis
KW - Image processing
KW - Optical coherence tomography
KW - Repeatability
KW - Reproducibility
KW - Retina
KW - Segmentation
UR - http://www.scopus.com/inward/record.url?scp=77950353418&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77950353418&partnerID=8YFLogxK
U2 - 10.1117/1.3268773
DO - 10.1117/1.3268773
M3 - Article
C2 - 20059261
AN - SCOPUS:77950353418
VL - 14
JO - Journal of Biomedical Optics
JF - Journal of Biomedical Optics
SN - 1083-3668
IS - 6
M1 - 064023
ER -