Abstract
HIV infection, once established, is never cleared. Rare individuals do, however, control viral replication to low levels. These successful immune responses are primarily linked to certain class I MHC alleles (MHC-I). Because of this association, many AIDS vaccines in development are designed to generate virus-specific CD8+ T cells. The Merck STEP phase 2b efficacy trial of one such vaccine was recently halted, and declared a failure. Thus, basic questions regarding what constitutes an effective T cell response and how such responses could be elicited by vaccination remain open. The best animal model available to explore such issues is simian immunodeficiency virus infection of rhesus macaques, which serves as the primary proving ground for AIDS vaccines.
| Original language | English |
|---|---|
| Pages (from-to) | 605-611 |
| Number of pages | 7 |
| Journal | Trends in Microbiology |
| Volume | 16 |
| Issue number | 12 |
| DOIs | |
| State | Published - Dec 1 2008 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Infectious Diseases
- Microbiology (medical)
- Microbiology
- Virology
Cite this
Relevance of studying T cell responses in SIV-infected rhesus macaques. / Valentine, Laura E.; Watkins, David.
In: Trends in Microbiology, Vol. 16, No. 12, 01.12.2008, p. 605-611.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Relevance of studying T cell responses in SIV-infected rhesus macaques
AU - Valentine, Laura E.
AU - Watkins, David
PY - 2008/12/1
Y1 - 2008/12/1
N2 - HIV infection, once established, is never cleared. Rare individuals do, however, control viral replication to low levels. These successful immune responses are primarily linked to certain class I MHC alleles (MHC-I). Because of this association, many AIDS vaccines in development are designed to generate virus-specific CD8+ T cells. The Merck STEP phase 2b efficacy trial of one such vaccine was recently halted, and declared a failure. Thus, basic questions regarding what constitutes an effective T cell response and how such responses could be elicited by vaccination remain open. The best animal model available to explore such issues is simian immunodeficiency virus infection of rhesus macaques, which serves as the primary proving ground for AIDS vaccines.
AB - HIV infection, once established, is never cleared. Rare individuals do, however, control viral replication to low levels. These successful immune responses are primarily linked to certain class I MHC alleles (MHC-I). Because of this association, many AIDS vaccines in development are designed to generate virus-specific CD8+ T cells. The Merck STEP phase 2b efficacy trial of one such vaccine was recently halted, and declared a failure. Thus, basic questions regarding what constitutes an effective T cell response and how such responses could be elicited by vaccination remain open. The best animal model available to explore such issues is simian immunodeficiency virus infection of rhesus macaques, which serves as the primary proving ground for AIDS vaccines.
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U2 - 10.1016/j.tim.2008.08.010
DO - 10.1016/j.tim.2008.08.010
M3 - Article
VL - 16
SP - 605
EP - 611
JO - Trends in Microbiology
JF - Trends in Microbiology
SN - 0966-842X
IS - 12
ER -