To study the effect of synthetic leutenizing hormone-releasing hormone (LH-RH) follicle stimulating hormone-releasing hormone (FSH-RH) on the release of LH and FSH in the human being, a decapeptide, synthesized by the solid phase method, was injected into normal volunteers 21-36 years old. There were 3 untreated men, 2 untreated women, 3 men pretreated with ethinyl estradiol and 3 women pretreated with an oral contraceptive (lyndiol). The synthetic hormone ((pyro)Glu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2) caused an increase in serum LH values over the control (p less than .01) with no difference between men and women in the amount of LH released. FH was also significantly (p less than .01) increased but to lower levels than LH. Pretreatment with sex steroids led to a decrease in FSH values (p less than .10). Since the hormone is readily synthesized in large quantities, clinical studies are now possible.
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Clinical Biochemistry
- Biochemistry, medical