Release of Collagenase, Neutral Protease, and Prostaglandins From Cultured Mammalian Synovial Cells by Hydroxyapatite and Calcium Pyrophosphate Dihydrate Crystals

Herman S. Cheung, Paul B. Halverson, Daniel J. Mccarty

Research output: Contribution to journalArticle

87 Scopus citations

Abstract

Hydroxyapatite (HA) and calcium pyrophosphate dihydrate (CPPD) crystals were phagocytosed when added to cultured human rheumatoid or normal canine synovial cells. Collagenase and neutral protease secretion into the culture medium was increased 5- to 8-fold over control values in the presence of HA and increased 3-fold in the presence of CPPD crystals. HA but not CPPD crystals induced a 300-fold increase in human rheumatoid synovial cell culture fluid prostaglandin (PG) E2 levels and an 8-fold increase in PGFα levels. This mechanism may be important in the pathogenesis of the destructive arthropathies associated with HA and CPPD crystals.

Original languageEnglish (US)
Pages (from-to)1338-1344
Number of pages7
JournalArthritis & Rheumatism
Volume24
Issue number11
DOIs
StatePublished - Nov 1981
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Rheumatology
  • Immunology
  • Pharmacology (medical)

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