Relationships between markers of vascular dysfunction and neurodevelopmental outcomes in perinatally HIV-infected youth

Suad Kapetanovic, Erin Leister, Sharon Nichols, Tracie Miller, Katherine Tassiopoulos, Rohan Hazra, Harris A. Gelbard, Kathleen M. Malee, Betsy Kammerer, Armando J. Mendez, Paige L. Williams

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

Objective: To examine the relationship between markers of vascular dysfunction and neurodevelopmental status in pediatric HIV disease. Design: A cross-sectional design within a prospective, 15-site cohort study conducted in the United States. Methods: Nine vascular biomarkers were examined in 89 HIV-infected children: soluble P-selectin/sCD62P, fibrinogen, adiponectin, monocyte chemoattractant protein-1/CCL-2, interleukin-6, C-reactive protein, soluble vascular cell adhesion molecule-1/sCD106, sE-selectin/sCD62E, and soluble intercellular adhesion molecule-1/sCD54. The Wechsler Intelligence Scale for Children-Fourth edition (WISC-IV) was administered yielding indices for verbal comprehension, perceptual reasoning, working memory and processing speed, and overall composite Full-Scale IQ score. Linear regression models were used to evaluate neurodevelopmental status (measured by WISC-IV scores) as a function of each biomarker while adjusting for demographics, disease severity, and receipt of HAART. Biomarker levels were evaluated in quartiles to evaluate trends in WISC-IV responses. Results: Among the 89 HIV-infected children (median age = 12 years), 56% were girls, 71% black, 16% Hispanic, and 43% had yearly household income below US $20 000. Log (soluble P-selectin) was significantly correlated with all WISC-IV scores; adjusted slopes showed 6-11-point average decrease in scores for each one log unit increase in soluble P-selectin. Final linear regression models for log (fibrinogen) adjusted for sociodemographic and disease characteristics also indicated a negative correlation with all WISC-IV scores (13-30-point decrease for each one log unit increase in fibrinogen); these decreases were significant in the verbal comprehension, perceptual reasoning, and Full-Scale IQ scores. Conclusion: Proinflammatory microvascular and immunologic mechanisms may be involved in neurodevelopmental impairment in children with perinatally acquired HIV disease.

Original languageEnglish (US)
Pages (from-to)1481-1491
Number of pages11
JournalAIDS
Volume24
Issue number10
DOIs
StatePublished - Jun 19 2010

Keywords

  • pediatric HIV
  • pediatric NeuroAIDS
  • role of chemokines in NeuroAIDS
  • vascular dysfunction and NeuroAIDS

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

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