Relationship of thyroid function with body mass index, leptin, insulin sensitivity and adiponectin in euthyroid obese women

Gianluca Iacobellis, Maria Cristina Ribaudo, Alessandra Zappaterreno, Concerta Valeria Iannucci, Frida Leonetti

Research output: Contribution to journalArticle

167 Citations (Scopus)

Abstract

Background: A possible relationship between thyroid hormones and adipose tissue metabolism in humans has been suggested. Aim of the study: We sought to evaluate thyroid function and its possible relationship with body mass index (BMI), leptin, adiponectin and insulin sensitivity in euthyroid obese women. Materials and methods: Eighty-seven uncomplicated obese women (mean age 34.7 ± 9 years, mean BMI 40.1 ± 7 kg/m2) were studied. Levels of TSH, free thyroxine (FT4), free triiodothyronine (FT3), plasma adiponectin and leptin were evaluated. Insulin sensitivity was assessed by euglycaemic hyperinsulinaemic clamp (M index), fasting insulin and HOMA-IR. Results: Uncomplicated obese women with BMI > 40 kg/m2 showed higher serum TSH than obese subjects with BMI < 40 kg/m2 (P < 0.01). TSH was correlated with BMI (r = 0.44, P = 0.01) leptin (r = 0.41, P = 0.01), leptin/BMI ratio (r = 0.33, P = 0.03), body surface area (r = 0.26, P = 0.05), HOMA-IR (r = 0.245, P = 0.05) and inversely with adiponectin (r = -0.25, P = 0.05) and M index (r = -0.223 P = 0.05). Conclusions: Our data show that, although thyroid function was normal in the studied obese population, TSH and BMI were positively related. TSH has been found to be correlated also with leptin adjusted for BMI. TSH could represent a marker of altered energy balance in severe, but uncomplicated obese women.

Original languageEnglish
Pages (from-to)487-491
Number of pages5
JournalClinical Endocrinology
Volume62
Issue number4
DOIs
StatePublished - Apr 1 2005
Externally publishedYes

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Adiponectin
Leptin
Insulin Resistance
Thyroid Gland
Body Mass Index
Glucose Clamp Technique
Body Surface Area
Triiodothyronine
Thyroxine
Thyroid Hormones
Adipose Tissue
Fasting
Insulin
Serum
Population

ASJC Scopus subject areas

  • Endocrinology

Cite this

Relationship of thyroid function with body mass index, leptin, insulin sensitivity and adiponectin in euthyroid obese women. / Iacobellis, Gianluca; Ribaudo, Maria Cristina; Zappaterreno, Alessandra; Iannucci, Concerta Valeria; Leonetti, Frida.

In: Clinical Endocrinology, Vol. 62, No. 4, 01.04.2005, p. 487-491.

Research output: Contribution to journalArticle

Iacobellis, Gianluca ; Ribaudo, Maria Cristina ; Zappaterreno, Alessandra ; Iannucci, Concerta Valeria ; Leonetti, Frida. / Relationship of thyroid function with body mass index, leptin, insulin sensitivity and adiponectin in euthyroid obese women. In: Clinical Endocrinology. 2005 ; Vol. 62, No. 4. pp. 487-491.
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