Relationship of oxygen dose to angiogenesis induction in irradiated tissue

Robert E. Marx, William J. Ehler, Pairot Tayapongsak, Leonard W. Pierce

Research output: Contribution to journalArticlepeer-review

361 Scopus citations


This study was accomplished in an irradiated rabbit model to assess the angiogenic properties of normobaric oxygen and hyperbaric oxygen as compared with air-breathing controls. Results indicated that normobaric oxygen had no angiogenic properties above normal revascularization of irradiated tissue than did air-breathing controls (p=0.89). Hyperbaric oxygen demonstrated an eight- to ninefold increased vascular density over both normobaric oxygen and air-breathing controls (p=0.001). Irradiated tissue develops a hypovacular-hypocellular-hypoxic tissue that does not revascularize spontaneously. Results failed to demonstrate an angiogenic effect of normobaric oxygen. It is suggested that oxygen in this sense is a drug requiring hyperbaric pressures to generate therapeutic effects on chronically hypovascular irradiated tissue.

Original languageEnglish (US)
Pages (from-to)519-524
Number of pages6
JournalThe American Journal of Surgery
Issue number5
StatePublished - Nov 1990
Externally publishedYes

ASJC Scopus subject areas

  • Surgery


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