Abstract
Background Left ventricular (LV) systolic strain provides additional prognostic value to LV ejection fraction (LVEF) and wall motion analysis. However, the relationship between myocardial multidirectional strain and LVEF, and the effect of LV hypertrophy on this relationship, are not completely understood especially in unselected populations. Methods LV global longitudinal (εL) and circumferential (εC) systolic strain analysis was performed by two-dimensional speckle tracking echocardiography in 215 participants from a community-based study. LV radial wall thickening was measured as global radial strain (εR), and LVEF was assessed by biplane Simpson's method. Results εR was significantly associated with εC (β = -0.56, P < 0.01) and with εL (β = -0.18, P < 0.01). The contribution of εL to εR was especially evident in subjects with lower εC and in presence of LV hypertrophy (β = -0.30, P < 0.01). εL and εC were significantly associated with LVEF (β = -0.36 and β = -0.49, both P < 0.01) independent of LV mass and other confounders, and their interaction significantly improved the prediction of LVEF (R2-change = 0.14) but not of εR (R2-change = 0.002). Conclusions εR is mainly related to εC with a smaller contribution of εL, which becomes especially evident in subjects with lower εC and in presence of LV hypertrophy. Therefore, radial thickening may not detect subclinical LV longitudinal function reduction in normal ventricles and when εC is preserved. While a reduction in εL has a limited impact on εR, it exerts a greater effect on global LVEF, therefore for a more accurate LVEF prediction both εL and εC need to be considered.
| Original language | English |
|---|---|
| Pages (from-to) | 794-802 |
| Number of pages | 9 |
| Journal | Echocardiography |
| Volume | 30 |
| Issue number | 7 |
| DOIs | |
| State | Published - Aug 1 2013 |
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Keywords
- echocardiography
- ejection fraction
- left ventricle
- speckle tracking
- strain
- systolic function
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
- Radiology Nuclear Medicine and imaging
Cite this
Relationship of multidirectional myocardial strain with radial thickening and ejection fraction and impact of left ventricular hypertrophy : A study in a community-based cohort. / Russo, Cesare; Jin, Zhezhen; Homma, Shunichi; Rundek, Tatjana; Elkind, Mitchell S V; Sacco, Ralph L; Di Tullio, Marco R.
In: Echocardiography, Vol. 30, No. 7, 01.08.2013, p. 794-802.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Relationship of multidirectional myocardial strain with radial thickening and ejection fraction and impact of left ventricular hypertrophy
T2 - A study in a community-based cohort
AU - Russo, Cesare
AU - Jin, Zhezhen
AU - Homma, Shunichi
AU - Rundek, Tatjana
AU - Elkind, Mitchell S V
AU - Sacco, Ralph L
AU - Di Tullio, Marco R.
PY - 2013/8/1
Y1 - 2013/8/1
N2 - Background Left ventricular (LV) systolic strain provides additional prognostic value to LV ejection fraction (LVEF) and wall motion analysis. However, the relationship between myocardial multidirectional strain and LVEF, and the effect of LV hypertrophy on this relationship, are not completely understood especially in unselected populations. Methods LV global longitudinal (εL) and circumferential (εC) systolic strain analysis was performed by two-dimensional speckle tracking echocardiography in 215 participants from a community-based study. LV radial wall thickening was measured as global radial strain (εR), and LVEF was assessed by biplane Simpson's method. Results εR was significantly associated with εC (β = -0.56, P < 0.01) and with εL (β = -0.18, P < 0.01). The contribution of εL to εR was especially evident in subjects with lower εC and in presence of LV hypertrophy (β = -0.30, P < 0.01). εL and εC were significantly associated with LVEF (β = -0.36 and β = -0.49, both P < 0.01) independent of LV mass and other confounders, and their interaction significantly improved the prediction of LVEF (R2-change = 0.14) but not of εR (R2-change = 0.002). Conclusions εR is mainly related to εC with a smaller contribution of εL, which becomes especially evident in subjects with lower εC and in presence of LV hypertrophy. Therefore, radial thickening may not detect subclinical LV longitudinal function reduction in normal ventricles and when εC is preserved. While a reduction in εL has a limited impact on εR, it exerts a greater effect on global LVEF, therefore for a more accurate LVEF prediction both εL and εC need to be considered.
AB - Background Left ventricular (LV) systolic strain provides additional prognostic value to LV ejection fraction (LVEF) and wall motion analysis. However, the relationship between myocardial multidirectional strain and LVEF, and the effect of LV hypertrophy on this relationship, are not completely understood especially in unselected populations. Methods LV global longitudinal (εL) and circumferential (εC) systolic strain analysis was performed by two-dimensional speckle tracking echocardiography in 215 participants from a community-based study. LV radial wall thickening was measured as global radial strain (εR), and LVEF was assessed by biplane Simpson's method. Results εR was significantly associated with εC (β = -0.56, P < 0.01) and with εL (β = -0.18, P < 0.01). The contribution of εL to εR was especially evident in subjects with lower εC and in presence of LV hypertrophy (β = -0.30, P < 0.01). εL and εC were significantly associated with LVEF (β = -0.36 and β = -0.49, both P < 0.01) independent of LV mass and other confounders, and their interaction significantly improved the prediction of LVEF (R2-change = 0.14) but not of εR (R2-change = 0.002). Conclusions εR is mainly related to εC with a smaller contribution of εL, which becomes especially evident in subjects with lower εC and in presence of LV hypertrophy. Therefore, radial thickening may not detect subclinical LV longitudinal function reduction in normal ventricles and when εC is preserved. While a reduction in εL has a limited impact on εR, it exerts a greater effect on global LVEF, therefore for a more accurate LVEF prediction both εL and εC need to be considered.
KW - echocardiography
KW - ejection fraction
KW - left ventricle
KW - speckle tracking
KW - strain
KW - systolic function
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U2 - 10.1111/echo.12134
DO - 10.1111/echo.12134
M3 - Article
VL - 30
SP - 794
EP - 802
JO - Echocardiography
JF - Echocardiography
SN - 0742-2822
IS - 7
ER -