Relationship of insulin sensitivity and left ventricular mass in uncomplicated obesity

Gianluca Iacobellis, Maria Cristina Ribaudo, Alessandra Zappaterreno, Elio Vecci, Claudio Tiberti, Umberto Di Mario, Frida Leonetti

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

Objective: We studied uncomplicated obesity as a model to evaluate the influence of insulin sensitivity per se on left ventricular mass (LVM) and geometry. Research Methods and Procedures: We selected 50 obese subjects (BMI > 30 kg/m2; 38 women and 12 men; mean age, 38.4 ± 10 years; BMI, 36.4 ± 10.5 kg/m2) with normal blood pressure, glucose tolerance, and plasmatic lipid levels. Thirty lean subjects formed the control group. Each subject underwent euglycemic insulin clamp (7 pmol/min per kg) to evaluate whole body glucose use (M index) and echocardiogram to calculate LVM and indexed LVM. Results: Insulin-resistant obese subjects had higher LVM, LVM/h2,7, LVM/body surface area, and LVM/fat-free masskg (p = 0.001; p = <0.001 p = 0.001, and p = 0.04, respectively) than obese subjects with normal insulin sensitivity. Multivariate regression analysis showed that M index was the strongest independent correlate of LVM (r 2 = 0.34; p = 0.03). Discussion: Our findings showed that insulin resistance, in uncomplicated obesity, is associated with an increased LVM and precocious changes of left ventricular geometry, whereas preserved insulin sensitivity is not associated with increased LVM.

Original languageEnglish
Pages (from-to)518-524
Number of pages7
JournalObesity Research
Volume11
Issue number4
StatePublished - Dec 1 2003
Externally publishedYes

Fingerprint

insulin resistance
Insulin Resistance
obesity
Obesity
Insulin
Glucose Clamp Technique
Body Surface Area
Blood Glucose
Multivariate Analysis
Fats
Regression Analysis
Blood Pressure
Lipids
Glucose
Control Groups
Research
glucose tolerance
research methods
lipids
blood pressure

Keywords

  • Echocardiography
  • Insulin resistance
  • Left ventricular hypertrophy

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Public Health, Environmental and Occupational Health
  • Endocrinology
  • Food Science
  • Endocrinology, Diabetes and Metabolism

Cite this

Iacobellis, G., Ribaudo, M. C., Zappaterreno, A., Vecci, E., Tiberti, C., Di Mario, U., & Leonetti, F. (2003). Relationship of insulin sensitivity and left ventricular mass in uncomplicated obesity. Obesity Research, 11(4), 518-524.

Relationship of insulin sensitivity and left ventricular mass in uncomplicated obesity. / Iacobellis, Gianluca; Ribaudo, Maria Cristina; Zappaterreno, Alessandra; Vecci, Elio; Tiberti, Claudio; Di Mario, Umberto; Leonetti, Frida.

In: Obesity Research, Vol. 11, No. 4, 01.12.2003, p. 518-524.

Research output: Contribution to journalArticle

Iacobellis, G, Ribaudo, MC, Zappaterreno, A, Vecci, E, Tiberti, C, Di Mario, U & Leonetti, F 2003, 'Relationship of insulin sensitivity and left ventricular mass in uncomplicated obesity', Obesity Research, vol. 11, no. 4, pp. 518-524.
Iacobellis G, Ribaudo MC, Zappaterreno A, Vecci E, Tiberti C, Di Mario U et al. Relationship of insulin sensitivity and left ventricular mass in uncomplicated obesity. Obesity Research. 2003 Dec 1;11(4):518-524.
Iacobellis, Gianluca ; Ribaudo, Maria Cristina ; Zappaterreno, Alessandra ; Vecci, Elio ; Tiberti, Claudio ; Di Mario, Umberto ; Leonetti, Frida. / Relationship of insulin sensitivity and left ventricular mass in uncomplicated obesity. In: Obesity Research. 2003 ; Vol. 11, No. 4. pp. 518-524.
@article{fdf3a87f3bfa49aa82874a00f8f56dba,
title = "Relationship of insulin sensitivity and left ventricular mass in uncomplicated obesity",
abstract = "Objective: We studied uncomplicated obesity as a model to evaluate the influence of insulin sensitivity per se on left ventricular mass (LVM) and geometry. Research Methods and Procedures: We selected 50 obese subjects (BMI > 30 kg/m2; 38 women and 12 men; mean age, 38.4 ± 10 years; BMI, 36.4 ± 10.5 kg/m2) with normal blood pressure, glucose tolerance, and plasmatic lipid levels. Thirty lean subjects formed the control group. Each subject underwent euglycemic insulin clamp (7 pmol/min per kg) to evaluate whole body glucose use (M index) and echocardiogram to calculate LVM and indexed LVM. Results: Insulin-resistant obese subjects had higher LVM, LVM/h2,7, LVM/body surface area, and LVM/fat-free masskg (p = 0.001; p = <0.001 p = 0.001, and p = 0.04, respectively) than obese subjects with normal insulin sensitivity. Multivariate regression analysis showed that M index was the strongest independent correlate of LVM (r 2 = 0.34; p = 0.03). Discussion: Our findings showed that insulin resistance, in uncomplicated obesity, is associated with an increased LVM and precocious changes of left ventricular geometry, whereas preserved insulin sensitivity is not associated with increased LVM.",
keywords = "Echocardiography, Insulin resistance, Left ventricular hypertrophy",
author = "Gianluca Iacobellis and Ribaudo, {Maria Cristina} and Alessandra Zappaterreno and Elio Vecci and Claudio Tiberti and {Di Mario}, Umberto and Frida Leonetti",
year = "2003",
month = "12",
day = "1",
language = "English",
volume = "11",
pages = "518--524",
journal = "Obesity",
issn = "1930-7381",
publisher = "Wiley-Blackwell",
number = "4",

}

TY - JOUR

T1 - Relationship of insulin sensitivity and left ventricular mass in uncomplicated obesity

AU - Iacobellis, Gianluca

AU - Ribaudo, Maria Cristina

AU - Zappaterreno, Alessandra

AU - Vecci, Elio

AU - Tiberti, Claudio

AU - Di Mario, Umberto

AU - Leonetti, Frida

PY - 2003/12/1

Y1 - 2003/12/1

N2 - Objective: We studied uncomplicated obesity as a model to evaluate the influence of insulin sensitivity per se on left ventricular mass (LVM) and geometry. Research Methods and Procedures: We selected 50 obese subjects (BMI > 30 kg/m2; 38 women and 12 men; mean age, 38.4 ± 10 years; BMI, 36.4 ± 10.5 kg/m2) with normal blood pressure, glucose tolerance, and plasmatic lipid levels. Thirty lean subjects formed the control group. Each subject underwent euglycemic insulin clamp (7 pmol/min per kg) to evaluate whole body glucose use (M index) and echocardiogram to calculate LVM and indexed LVM. Results: Insulin-resistant obese subjects had higher LVM, LVM/h2,7, LVM/body surface area, and LVM/fat-free masskg (p = 0.001; p = <0.001 p = 0.001, and p = 0.04, respectively) than obese subjects with normal insulin sensitivity. Multivariate regression analysis showed that M index was the strongest independent correlate of LVM (r 2 = 0.34; p = 0.03). Discussion: Our findings showed that insulin resistance, in uncomplicated obesity, is associated with an increased LVM and precocious changes of left ventricular geometry, whereas preserved insulin sensitivity is not associated with increased LVM.

AB - Objective: We studied uncomplicated obesity as a model to evaluate the influence of insulin sensitivity per se on left ventricular mass (LVM) and geometry. Research Methods and Procedures: We selected 50 obese subjects (BMI > 30 kg/m2; 38 women and 12 men; mean age, 38.4 ± 10 years; BMI, 36.4 ± 10.5 kg/m2) with normal blood pressure, glucose tolerance, and plasmatic lipid levels. Thirty lean subjects formed the control group. Each subject underwent euglycemic insulin clamp (7 pmol/min per kg) to evaluate whole body glucose use (M index) and echocardiogram to calculate LVM and indexed LVM. Results: Insulin-resistant obese subjects had higher LVM, LVM/h2,7, LVM/body surface area, and LVM/fat-free masskg (p = 0.001; p = <0.001 p = 0.001, and p = 0.04, respectively) than obese subjects with normal insulin sensitivity. Multivariate regression analysis showed that M index was the strongest independent correlate of LVM (r 2 = 0.34; p = 0.03). Discussion: Our findings showed that insulin resistance, in uncomplicated obesity, is associated with an increased LVM and precocious changes of left ventricular geometry, whereas preserved insulin sensitivity is not associated with increased LVM.

KW - Echocardiography

KW - Insulin resistance

KW - Left ventricular hypertrophy

UR - http://www.scopus.com/inward/record.url?scp=0142186763&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0142186763&partnerID=8YFLogxK

M3 - Article

C2 - 12690080

AN - SCOPUS:0142186763

VL - 11

SP - 518

EP - 524

JO - Obesity

JF - Obesity

SN - 1930-7381

IS - 4

ER -