Relationship of erythrocyte membrane polyunsaturated fatty acids and prostate-specific antigen levels in Jamaican men

Chad Ritch, C. B. Brendler, R. L. Wan, K. E. Pickett, M. H. Sokoloff

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

OBJECTIVE: To investigate the relationship between erythrocyte membrane polyunsaturated fatty acid (PUFA) and serum prostate-specific antigen (PSA) levels in Jamaican men, as there may be an association between prostate cancer incidence and dietary fatty acids, and prostate cancer incidence in Jamaica is among the highest in the world. PATIENTS AND METHODS: Blood from 107 Jamaican men was analysed for 32 individual fatty acids and PSA levels. Special attention was given to correlations between Ω3 and Ω6 PUFAs and PSA. Data were analysed using standard linear regression methods. RESULTS: The mean PSA was 18.6 ng/mL (normal 0-4.0); for age groups of 51-60, 61-70 and 71-80 years the levels were 14, 26 and 23 ng/ mL, respectively. Eicosapentaenoic acid (Ω3) levels decreased as PSA exceeded 10 ng/mL (P = 0.02). Arachidonic acid (Ω6) levels decreased as PSA was <2 ng/mL (P = 0.02). Linoleic acid (Ω6) levels decreased in men with PSA levels of 2-10 ng/mL (P = 0.04). In men with a PSA of > 10 ng/mL there was a positive correlation between the ratio of Ω6 to Ω3 PUFAs and PSA (P = 0.036); there was also a negative correlation between the ratio of Ω3 to Ω6 PUFAs and PSA (P = 0.08). When the ratio of Ω3 PUFAs over the products of Ω6 PUFAs were used, this trend was significant (P = 0.03). CONCLUSIONS: Increased levels of Ω6 PUFAs and the ratio of Ω6/Ω3 PUFAs in Jamaican men are associated with an increased mean PSA level and risk of prostate cancer. Additional studies are needed to establish a causal link between dietary fatty acid intake and the development of prostate cancer in Jamaican men.

Original languageEnglish (US)
Pages (from-to)1211-1215
Number of pages5
JournalBJU International
Volume93
Issue number9
DOIs
StatePublished - Jun 2004
Externally publishedYes

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Erythrocyte Membrane
Prostate-Specific Antigen
Unsaturated Fatty Acids
Prostatic Neoplasms
Fatty Acids
Jamaica
Eicosapentaenoic Acid
Incidence
Arachidonic Acid
Linear Models
Age Groups
Serum

Keywords

  • Jamaica
  • Polyunsaturated fatty acids
  • Prostate cancer
  • PSA

ASJC Scopus subject areas

  • Urology

Cite this

Relationship of erythrocyte membrane polyunsaturated fatty acids and prostate-specific antigen levels in Jamaican men. / Ritch, Chad; Brendler, C. B.; Wan, R. L.; Pickett, K. E.; Sokoloff, M. H.

In: BJU International, Vol. 93, No. 9, 06.2004, p. 1211-1215.

Research output: Contribution to journalArticle

Ritch, Chad ; Brendler, C. B. ; Wan, R. L. ; Pickett, K. E. ; Sokoloff, M. H. / Relationship of erythrocyte membrane polyunsaturated fatty acids and prostate-specific antigen levels in Jamaican men. In: BJU International. 2004 ; Vol. 93, No. 9. pp. 1211-1215.
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abstract = "OBJECTIVE: To investigate the relationship between erythrocyte membrane polyunsaturated fatty acid (PUFA) and serum prostate-specific antigen (PSA) levels in Jamaican men, as there may be an association between prostate cancer incidence and dietary fatty acids, and prostate cancer incidence in Jamaica is among the highest in the world. PATIENTS AND METHODS: Blood from 107 Jamaican men was analysed for 32 individual fatty acids and PSA levels. Special attention was given to correlations between Ω3 and Ω6 PUFAs and PSA. Data were analysed using standard linear regression methods. RESULTS: The mean PSA was 18.6 ng/mL (normal 0-4.0); for age groups of 51-60, 61-70 and 71-80 years the levels were 14, 26 and 23 ng/ mL, respectively. Eicosapentaenoic acid (Ω3) levels decreased as PSA exceeded 10 ng/mL (P = 0.02). Arachidonic acid (Ω6) levels decreased as PSA was <2 ng/mL (P = 0.02). Linoleic acid (Ω6) levels decreased in men with PSA levels of 2-10 ng/mL (P = 0.04). In men with a PSA of > 10 ng/mL there was a positive correlation between the ratio of Ω6 to Ω3 PUFAs and PSA (P = 0.036); there was also a negative correlation between the ratio of Ω3 to Ω6 PUFAs and PSA (P = 0.08). When the ratio of Ω3 PUFAs over the products of Ω6 PUFAs were used, this trend was significant (P = 0.03). CONCLUSIONS: Increased levels of Ω6 PUFAs and the ratio of Ω6/Ω3 PUFAs in Jamaican men are associated with an increased mean PSA level and risk of prostate cancer. Additional studies are needed to establish a causal link between dietary fatty acid intake and the development of prostate cancer in Jamaican men.",
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T1 - Relationship of erythrocyte membrane polyunsaturated fatty acids and prostate-specific antigen levels in Jamaican men

AU - Ritch, Chad

AU - Brendler, C. B.

AU - Wan, R. L.

AU - Pickett, K. E.

AU - Sokoloff, M. H.

PY - 2004/6

Y1 - 2004/6

N2 - OBJECTIVE: To investigate the relationship between erythrocyte membrane polyunsaturated fatty acid (PUFA) and serum prostate-specific antigen (PSA) levels in Jamaican men, as there may be an association between prostate cancer incidence and dietary fatty acids, and prostate cancer incidence in Jamaica is among the highest in the world. PATIENTS AND METHODS: Blood from 107 Jamaican men was analysed for 32 individual fatty acids and PSA levels. Special attention was given to correlations between Ω3 and Ω6 PUFAs and PSA. Data were analysed using standard linear regression methods. RESULTS: The mean PSA was 18.6 ng/mL (normal 0-4.0); for age groups of 51-60, 61-70 and 71-80 years the levels were 14, 26 and 23 ng/ mL, respectively. Eicosapentaenoic acid (Ω3) levels decreased as PSA exceeded 10 ng/mL (P = 0.02). Arachidonic acid (Ω6) levels decreased as PSA was <2 ng/mL (P = 0.02). Linoleic acid (Ω6) levels decreased in men with PSA levels of 2-10 ng/mL (P = 0.04). In men with a PSA of > 10 ng/mL there was a positive correlation between the ratio of Ω6 to Ω3 PUFAs and PSA (P = 0.036); there was also a negative correlation between the ratio of Ω3 to Ω6 PUFAs and PSA (P = 0.08). When the ratio of Ω3 PUFAs over the products of Ω6 PUFAs were used, this trend was significant (P = 0.03). CONCLUSIONS: Increased levels of Ω6 PUFAs and the ratio of Ω6/Ω3 PUFAs in Jamaican men are associated with an increased mean PSA level and risk of prostate cancer. Additional studies are needed to establish a causal link between dietary fatty acid intake and the development of prostate cancer in Jamaican men.

AB - OBJECTIVE: To investigate the relationship between erythrocyte membrane polyunsaturated fatty acid (PUFA) and serum prostate-specific antigen (PSA) levels in Jamaican men, as there may be an association between prostate cancer incidence and dietary fatty acids, and prostate cancer incidence in Jamaica is among the highest in the world. PATIENTS AND METHODS: Blood from 107 Jamaican men was analysed for 32 individual fatty acids and PSA levels. Special attention was given to correlations between Ω3 and Ω6 PUFAs and PSA. Data were analysed using standard linear regression methods. RESULTS: The mean PSA was 18.6 ng/mL (normal 0-4.0); for age groups of 51-60, 61-70 and 71-80 years the levels were 14, 26 and 23 ng/ mL, respectively. Eicosapentaenoic acid (Ω3) levels decreased as PSA exceeded 10 ng/mL (P = 0.02). Arachidonic acid (Ω6) levels decreased as PSA was <2 ng/mL (P = 0.02). Linoleic acid (Ω6) levels decreased in men with PSA levels of 2-10 ng/mL (P = 0.04). In men with a PSA of > 10 ng/mL there was a positive correlation between the ratio of Ω6 to Ω3 PUFAs and PSA (P = 0.036); there was also a negative correlation between the ratio of Ω3 to Ω6 PUFAs and PSA (P = 0.08). When the ratio of Ω3 PUFAs over the products of Ω6 PUFAs were used, this trend was significant (P = 0.03). CONCLUSIONS: Increased levels of Ω6 PUFAs and the ratio of Ω6/Ω3 PUFAs in Jamaican men are associated with an increased mean PSA level and risk of prostate cancer. Additional studies are needed to establish a causal link between dietary fatty acid intake and the development of prostate cancer in Jamaican men.

KW - Jamaica

KW - Polyunsaturated fatty acids

KW - Prostate cancer

KW - PSA

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