Relationship of cognitive functioning, adaptive life skills, and negative symptom severity in poor-outcome geriatric schizophrenia patients

Susan R. McGurk, Patrick J. Moriarty, Philip D. Harvey, Michael Parrella, Leonard White, Joseph Friedman, Kenneth L. Davis

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

The authors assessed whether cognitive functioning and negative symptoms are related to functional outcome across severity of negative symptoms and examined relationships between symptom domains in patients with high versus low negative symptom severity. The interrelationships between cognitive functioning and functional skills in poor-outcome geriatric schizophrenic patients were compared between those who were in the first (n = 81) and the fourth quartiles (n = 127) of negative symptom severity based on the normative data in the Positive and Negative Syndrome Scale. It was found that negative symptoms and cognitive functioning were the strongest correlates of functional status in geriatric poor-outcome schizophrenic patients-regardless of negative symptom severity. Interestingly, the greater the severity of negative symptoms, the less strongly negative symptoms were related to functional outcome. The present findings demonstrate that the relationship of cognitive functioning to social and adaptive functioning remains Significant despite differing levels of negative symptom severity.

Original languageEnglish (US)
Pages (from-to)257-264
Number of pages8
JournalJournal of Neuropsychiatry and Clinical Neurosciences
Volume12
Issue number2
DOIs
StatePublished - Jan 1 2000
Externally publishedYes

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ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health

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