TY - JOUR
T1 - Relationship of behavioral and psychological symptoms to cognitive impairment and functional status in Alzheimer's disease
AU - Harwood, Dylan G.
AU - Barker, Warren W.
AU - Ownby, Raymond L.
AU - Duara, Ranjan
PY - 2000/5/1
Y1 - 2000/5/1
N2 - Objective: This cross-sectional study examined the relationship of behavioral and psychological symptoms to cognitive and functional impairment in Alzheimer's disease (AD). Design: One hundred and fourteen patients were evaluated consecutively at a university-affiliated outpatient memory disorders clinic and diagnosed with possible or probable Alzheimer's disease (AD) according to NINCDS-ADRDA criteria. Subjects were assessed with the Behavioral Pathology in Alzheimer's Disease Scale (BEHAVE-AD), Revised Memory and Behavior Problem Checklist (RMBPC), Blessed Dementia Scale (BDS), and Mini-Mental State Examination (MMSE). Results: Several symptoms of behavioral pathology showed associations with MMSE scores, including activity disturbances, delusions, and hallucinations. After controlling for the variance associated with the MMSE, activity disturbances, diurnal disturbances, delusions, and hallucinations were linked with BDS scores. Conclusions: The results suggest that some non-cognitive symptoms may be related to the neurobiologic mechanisms underlying the increased cognitive dysfunction in AD. Specific symptoms of behavioral pathology may also impact a patient's ability to perform important self-maintenance behaviors. Copyright (C) 2000 John Wiley and Sons, Ltd.
AB - Objective: This cross-sectional study examined the relationship of behavioral and psychological symptoms to cognitive and functional impairment in Alzheimer's disease (AD). Design: One hundred and fourteen patients were evaluated consecutively at a university-affiliated outpatient memory disorders clinic and diagnosed with possible or probable Alzheimer's disease (AD) according to NINCDS-ADRDA criteria. Subjects were assessed with the Behavioral Pathology in Alzheimer's Disease Scale (BEHAVE-AD), Revised Memory and Behavior Problem Checklist (RMBPC), Blessed Dementia Scale (BDS), and Mini-Mental State Examination (MMSE). Results: Several symptoms of behavioral pathology showed associations with MMSE scores, including activity disturbances, delusions, and hallucinations. After controlling for the variance associated with the MMSE, activity disturbances, diurnal disturbances, delusions, and hallucinations were linked with BDS scores. Conclusions: The results suggest that some non-cognitive symptoms may be related to the neurobiologic mechanisms underlying the increased cognitive dysfunction in AD. Specific symptoms of behavioral pathology may also impact a patient's ability to perform important self-maintenance behaviors. Copyright (C) 2000 John Wiley and Sons, Ltd.
KW - Alzheimer's disease
KW - Behavioral pathology
KW - Cognitive impairment
KW - Functional status
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U2 - 10.1002/(SICI)1099-1166(200005)15:5<393::AID-GPS120>3.0.CO;2-O
DO - 10.1002/(SICI)1099-1166(200005)15:5<393::AID-GPS120>3.0.CO;2-O
M3 - Article
C2 - 10822237
AN - SCOPUS:0034035287
VL - 15
SP - 393
EP - 400
JO - International Journal of Geriatric Psychiatry
JF - International Journal of Geriatric Psychiatry
SN - 0885-6230
IS - 5
ER -