Relationship of behavioral and psychological symptoms to cognitive impairment and functional status in Alzheimer's disease

Dylan G. Harwood, Warren W. Barker, Raymond L. Ownby, Ranjan Duara

Research output: Contribution to journalArticlepeer-review

93 Scopus citations


Objective: This cross-sectional study examined the relationship of behavioral and psychological symptoms to cognitive and functional impairment in Alzheimer's disease (AD). Design: One hundred and fourteen patients were evaluated consecutively at a university-affiliated outpatient memory disorders clinic and diagnosed with possible or probable Alzheimer's disease (AD) according to NINCDS-ADRDA criteria. Subjects were assessed with the Behavioral Pathology in Alzheimer's Disease Scale (BEHAVE-AD), Revised Memory and Behavior Problem Checklist (RMBPC), Blessed Dementia Scale (BDS), and Mini-Mental State Examination (MMSE). Results: Several symptoms of behavioral pathology showed associations with MMSE scores, including activity disturbances, delusions, and hallucinations. After controlling for the variance associated with the MMSE, activity disturbances, diurnal disturbances, delusions, and hallucinations were linked with BDS scores. Conclusions: The results suggest that some non-cognitive symptoms may be related to the neurobiologic mechanisms underlying the increased cognitive dysfunction in AD. Specific symptoms of behavioral pathology may also impact a patient's ability to perform important self-maintenance behaviors. Copyright (C) 2000 John Wiley and Sons, Ltd.

Original languageEnglish (US)
Pages (from-to)393-400
Number of pages8
JournalInternational Journal of Geriatric Psychiatry
Issue number5
StatePublished - May 1 2000


  • Alzheimer's disease
  • Behavioral pathology
  • Cognitive impairment
  • Functional status

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Psychiatry and Mental health


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