Relationship of auer rods and chromosome findings to outcome in eighty-nine adults with acute nonlymphoblastic leukemia

Mark G. Kris, Roland Mertelsmann, Suresh Jhanwar, R. Chaganti, Ted H. Szatrowski, Timothy S. Gee, Zalmen Arlin, Sanford Kempin, Pasquale W Benedetto, Bayard Clarkson

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

We performed cytogenetic analyses using banding techniques on 89 adults with acute nonlymphoblastic leukemia prior to receiving protocol chemotherapy. The relationships of cytogenetic findings both to outcome and to other pretreatment variables (particularly the presence or absence of Auer rods) were analyzed. Patients were followed up to 90+ months. When patients were grouped according to cytogenetic findings (NN: all normal metaphases; AA: all abnormal metaphases; AN: both normal and abnormal metaphases; F: no evaluable metaphases; I: insufficient (less than three) metaphases) no significant differences were noted with regard to age, sex, terminal transferase positivity, complete remission rate, remission duration or survival. The marrow aspirates of patients with only normal (69%) metaphases or no evaluable metaphases (64%) were more likely to display Auer rods than specimens from individuals with only abnormal (26%) or a mixture of normal and abnormal (42%) metaphases (p=0.03). The presence of Auer rods in the pretreatment marrow aspirate was associated with an increased complete remission rate (71% vs 41%, p=0.004), median remission duration (12 months vs 9 months, p=0.02), and median survival (13 months vs 4 months, p=0.01). Using multivariable analyses, the presence or absence of Auer rods was the pretreatment factor that most significantly predicted response and survival in this group of patients. The presence of a normal karyotype in the initial cytogenetic preparation is associated with the presence of Auer rods. The finding of Auer rods in the initial bone marrow predicts greater response and longer survival in acute nonlymphoblastic leukemia.

Original languageEnglish
Pages (from-to)1231-1235
Number of pages5
JournalLeukemia Research
Volume9
Issue number10
DOIs
StatePublished - Jan 1 1985
Externally publishedYes

Fingerprint

Metaphase
Acute Myeloid Leukemia
Chromosomes
Cytogenetics
Survival
Bone Marrow
Cytogenetic Analysis
Transferases
Karyotype
Drug Therapy

Keywords

  • Acute nonlymphoblastic leukemia
  • Auer rods
  • chromosomes
  • cytogenetics
  • prognostic factors

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology

Cite this

Kris, M. G., Mertelsmann, R., Jhanwar, S., Chaganti, R., Szatrowski, T. H., Gee, T. S., ... Clarkson, B. (1985). Relationship of auer rods and chromosome findings to outcome in eighty-nine adults with acute nonlymphoblastic leukemia. Leukemia Research, 9(10), 1231-1235. https://doi.org/10.1016/0145-2126(85)90150-X

Relationship of auer rods and chromosome findings to outcome in eighty-nine adults with acute nonlymphoblastic leukemia. / Kris, Mark G.; Mertelsmann, Roland; Jhanwar, Suresh; Chaganti, R.; Szatrowski, Ted H.; Gee, Timothy S.; Arlin, Zalmen; Kempin, Sanford; Benedetto, Pasquale W; Clarkson, Bayard.

In: Leukemia Research, Vol. 9, No. 10, 01.01.1985, p. 1231-1235.

Research output: Contribution to journalArticle

Kris, MG, Mertelsmann, R, Jhanwar, S, Chaganti, R, Szatrowski, TH, Gee, TS, Arlin, Z, Kempin, S, Benedetto, PW & Clarkson, B 1985, 'Relationship of auer rods and chromosome findings to outcome in eighty-nine adults with acute nonlymphoblastic leukemia', Leukemia Research, vol. 9, no. 10, pp. 1231-1235. https://doi.org/10.1016/0145-2126(85)90150-X
Kris, Mark G. ; Mertelsmann, Roland ; Jhanwar, Suresh ; Chaganti, R. ; Szatrowski, Ted H. ; Gee, Timothy S. ; Arlin, Zalmen ; Kempin, Sanford ; Benedetto, Pasquale W ; Clarkson, Bayard. / Relationship of auer rods and chromosome findings to outcome in eighty-nine adults with acute nonlymphoblastic leukemia. In: Leukemia Research. 1985 ; Vol. 9, No. 10. pp. 1231-1235.
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abstract = "We performed cytogenetic analyses using banding techniques on 89 adults with acute nonlymphoblastic leukemia prior to receiving protocol chemotherapy. The relationships of cytogenetic findings both to outcome and to other pretreatment variables (particularly the presence or absence of Auer rods) were analyzed. Patients were followed up to 90+ months. When patients were grouped according to cytogenetic findings (NN: all normal metaphases; AA: all abnormal metaphases; AN: both normal and abnormal metaphases; F: no evaluable metaphases; I: insufficient (less than three) metaphases) no significant differences were noted with regard to age, sex, terminal transferase positivity, complete remission rate, remission duration or survival. The marrow aspirates of patients with only normal (69{\%}) metaphases or no evaluable metaphases (64{\%}) were more likely to display Auer rods than specimens from individuals with only abnormal (26{\%}) or a mixture of normal and abnormal (42{\%}) metaphases (p=0.03). The presence of Auer rods in the pretreatment marrow aspirate was associated with an increased complete remission rate (71{\%} vs 41{\%}, p=0.004), median remission duration (12 months vs 9 months, p=0.02), and median survival (13 months vs 4 months, p=0.01). Using multivariable analyses, the presence or absence of Auer rods was the pretreatment factor that most significantly predicted response and survival in this group of patients. The presence of a normal karyotype in the initial cytogenetic preparation is associated with the presence of Auer rods. The finding of Auer rods in the initial bone marrow predicts greater response and longer survival in acute nonlymphoblastic leukemia.",
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AB - We performed cytogenetic analyses using banding techniques on 89 adults with acute nonlymphoblastic leukemia prior to receiving protocol chemotherapy. The relationships of cytogenetic findings both to outcome and to other pretreatment variables (particularly the presence or absence of Auer rods) were analyzed. Patients were followed up to 90+ months. When patients were grouped according to cytogenetic findings (NN: all normal metaphases; AA: all abnormal metaphases; AN: both normal and abnormal metaphases; F: no evaluable metaphases; I: insufficient (less than three) metaphases) no significant differences were noted with regard to age, sex, terminal transferase positivity, complete remission rate, remission duration or survival. The marrow aspirates of patients with only normal (69%) metaphases or no evaluable metaphases (64%) were more likely to display Auer rods than specimens from individuals with only abnormal (26%) or a mixture of normal and abnormal (42%) metaphases (p=0.03). The presence of Auer rods in the pretreatment marrow aspirate was associated with an increased complete remission rate (71% vs 41%, p=0.004), median remission duration (12 months vs 9 months, p=0.02), and median survival (13 months vs 4 months, p=0.01). Using multivariable analyses, the presence or absence of Auer rods was the pretreatment factor that most significantly predicted response and survival in this group of patients. The presence of a normal karyotype in the initial cytogenetic preparation is associated with the presence of Auer rods. The finding of Auer rods in the initial bone marrow predicts greater response and longer survival in acute nonlymphoblastic leukemia.

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