Relationship between transient and steady-state pattern electroretinograms: Theoretical and experimental assessment

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Abstract

CONCLUSIONS. The study shows that PERGSS results from the overlapping of tr PERGtr waveforms generated at that reversal rate. The first two peaks (NSS and PSS) of the PERGSS reflect N35 and P50 waves of the tr PERGtr. The N95 amplitude is reduced at conventional (16 rps) SS rates, but contributes to the overall PERGSS amplitude.

PURPOSE. We determined if the overlap of transient (tr) pattern electroretinograms (PERGtr) can explain the generation of the steady-state (SS) pattern electroretinogram (PERGSS), and investigated the relationship between the two types of responses.

METHODS. Slightly jittered pattern reversals were used to generate quasi SS (QSS) PERGSS responses from eight normal subjects, recorded using lower eyelid skin electrodes, at rates between 6.9 and 26.5 reversals per second (rps). Jittered quasi PERGSS were deconvolved using the frequency domain continuous loop averaging deconvolution method. Additionally, conventional PERGtr at 2.2 rps and PERGSS at each of the QSS stimulation rates were obtained from all subjects. Two synthetic PERGSS responses were constructed at each stimulation rate, one using the PERGtr obtained at that rate, and the other using the conventional 2.2 rps PERGtr. Synthetic responses then were compared to the recorded PERGSS using amplitude, latency, and spectral measurements.

RESULTS. Findings indicate that the PERGSS obtained at SS rates can be predicted using the superposition of deconvolved tr PERGs at each particular rate. Although conventional PERGtr can explain PERGSS obtained at rates below 15.4 rps (≥97% correlation), for higher reversal rates only deconvolved responses obtained at that rate can produce the recorded SS responses (96% vs. 65% correlation at 26.5 rps).

Original languageEnglish
Pages (from-to)8560-8570
Number of pages11
JournalInvestigative Ophthalmology and Visual Science
Volume55
Issue number12
DOIs
StatePublished - Nov 18 2014

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Eyelids
Evoked Potentials
Electrodes
Skin

Keywords

  • Deconvolution
  • Overlap
  • Pattern electroretinogram
  • Steady-state PERG
  • Superposition
  • Transient PERG

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

Cite this

@article{03be2ff4e18a423285f77f9bcae8e5b1,
title = "Relationship between transient and steady-state pattern electroretinograms: Theoretical and experimental assessment",
abstract = "CONCLUSIONS. The study shows that PERGSS results from the overlapping of tr PERGtr waveforms generated at that reversal rate. The first two peaks (NSS and PSS) of the PERGSS reflect N35 and P50 waves of the tr PERGtr. The N95 amplitude is reduced at conventional (16 rps) SS rates, but contributes to the overall PERGSS amplitude.PURPOSE. We determined if the overlap of transient (tr) pattern electroretinograms (PERGtr) can explain the generation of the steady-state (SS) pattern electroretinogram (PERGSS), and investigated the relationship between the two types of responses.METHODS. Slightly jittered pattern reversals were used to generate quasi SS (QSS) PERGSS responses from eight normal subjects, recorded using lower eyelid skin electrodes, at rates between 6.9 and 26.5 reversals per second (rps). Jittered quasi PERGSS were deconvolved using the frequency domain continuous loop averaging deconvolution method. Additionally, conventional PERGtr at 2.2 rps and PERGSS at each of the QSS stimulation rates were obtained from all subjects. Two synthetic PERGSS responses were constructed at each stimulation rate, one using the PERGtr obtained at that rate, and the other using the conventional 2.2 rps PERGtr. Synthetic responses then were compared to the recorded PERGSS using amplitude, latency, and spectral measurements.RESULTS. Findings indicate that the PERGSS obtained at SS rates can be predicted using the superposition of deconvolved tr PERGs at each particular rate. Although conventional PERGtr can explain PERGSS obtained at rates below 15.4 rps (≥97{\%} correlation), for higher reversal rates only deconvolved responses obtained at that rate can produce the recorded SS responses (96{\%} vs. 65{\%} correlation at 26.5 rps).",
keywords = "Deconvolution, Overlap, Pattern electroretinogram, Steady-state PERG, Superposition, Transient PERG",
author = "Ozcan Ozdamar and Jonathon Toft-Nielsen and Jorge Bohorquez and Vittorio Porciatti",
year = "2014",
month = "11",
day = "18",
doi = "10.1167/iovs.14-15685",
language = "English",
volume = "55",
pages = "8560--8570",
journal = "Investigative Ophthalmology and Visual Science",
issn = "0146-0404",
publisher = "Association for Research in Vision and Ophthalmology Inc.",
number = "12",

}

TY - JOUR

T1 - Relationship between transient and steady-state pattern electroretinograms

T2 - Theoretical and experimental assessment

AU - Ozdamar, Ozcan

AU - Toft-Nielsen, Jonathon

AU - Bohorquez, Jorge

AU - Porciatti, Vittorio

PY - 2014/11/18

Y1 - 2014/11/18

N2 - CONCLUSIONS. The study shows that PERGSS results from the overlapping of tr PERGtr waveforms generated at that reversal rate. The first two peaks (NSS and PSS) of the PERGSS reflect N35 and P50 waves of the tr PERGtr. The N95 amplitude is reduced at conventional (16 rps) SS rates, but contributes to the overall PERGSS amplitude.PURPOSE. We determined if the overlap of transient (tr) pattern electroretinograms (PERGtr) can explain the generation of the steady-state (SS) pattern electroretinogram (PERGSS), and investigated the relationship between the two types of responses.METHODS. Slightly jittered pattern reversals were used to generate quasi SS (QSS) PERGSS responses from eight normal subjects, recorded using lower eyelid skin electrodes, at rates between 6.9 and 26.5 reversals per second (rps). Jittered quasi PERGSS were deconvolved using the frequency domain continuous loop averaging deconvolution method. Additionally, conventional PERGtr at 2.2 rps and PERGSS at each of the QSS stimulation rates were obtained from all subjects. Two synthetic PERGSS responses were constructed at each stimulation rate, one using the PERGtr obtained at that rate, and the other using the conventional 2.2 rps PERGtr. Synthetic responses then were compared to the recorded PERGSS using amplitude, latency, and spectral measurements.RESULTS. Findings indicate that the PERGSS obtained at SS rates can be predicted using the superposition of deconvolved tr PERGs at each particular rate. Although conventional PERGtr can explain PERGSS obtained at rates below 15.4 rps (≥97% correlation), for higher reversal rates only deconvolved responses obtained at that rate can produce the recorded SS responses (96% vs. 65% correlation at 26.5 rps).

AB - CONCLUSIONS. The study shows that PERGSS results from the overlapping of tr PERGtr waveforms generated at that reversal rate. The first two peaks (NSS and PSS) of the PERGSS reflect N35 and P50 waves of the tr PERGtr. The N95 amplitude is reduced at conventional (16 rps) SS rates, but contributes to the overall PERGSS amplitude.PURPOSE. We determined if the overlap of transient (tr) pattern electroretinograms (PERGtr) can explain the generation of the steady-state (SS) pattern electroretinogram (PERGSS), and investigated the relationship between the two types of responses.METHODS. Slightly jittered pattern reversals were used to generate quasi SS (QSS) PERGSS responses from eight normal subjects, recorded using lower eyelid skin electrodes, at rates between 6.9 and 26.5 reversals per second (rps). Jittered quasi PERGSS were deconvolved using the frequency domain continuous loop averaging deconvolution method. Additionally, conventional PERGtr at 2.2 rps and PERGSS at each of the QSS stimulation rates were obtained from all subjects. Two synthetic PERGSS responses were constructed at each stimulation rate, one using the PERGtr obtained at that rate, and the other using the conventional 2.2 rps PERGtr. Synthetic responses then were compared to the recorded PERGSS using amplitude, latency, and spectral measurements.RESULTS. Findings indicate that the PERGSS obtained at SS rates can be predicted using the superposition of deconvolved tr PERGs at each particular rate. Although conventional PERGtr can explain PERGSS obtained at rates below 15.4 rps (≥97% correlation), for higher reversal rates only deconvolved responses obtained at that rate can produce the recorded SS responses (96% vs. 65% correlation at 26.5 rps).

KW - Deconvolution

KW - Overlap

KW - Pattern electroretinogram

KW - Steady-state PERG

KW - Superposition

KW - Transient PERG

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U2 - 10.1167/iovs.14-15685

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JO - Investigative Ophthalmology and Visual Science

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