Relationship between the MDS-UPDRS domains and the health-related quality of life of Parkinson's disease patients

P. Martínez-Martín, C. Rodríguez-Blázquez, M. J. Forjaz, M. Álvarez-Sánchez, T. Arakaki, A. Bergareche-Yarza, A. Chade, N. Garretto, O. Gershanik, M. M. Kurtis, J. C. Martínez-Castrillo, A. Mendoza-Rodríguez, H. P. Moore, M. Rodríguez-Violante, C. Singer, B. C. Tilley, J. Huang, G. T. Stebbins, C. G. Goetz

Research output: Contribution to journalArticlepeer-review

32 Scopus citations


Background and purpose: The Movement Disorder Society sponsored version of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS) is a comprehensive instrument for assessing Parkinson's disease (PD). The present study was aimed at determining the relationships between MDS-UPDRS components and health-related quality of life (HRQoL) evaluations in PD patients. Methods: An international, multicenter, cross-sectional study was carried out of 435 PD patients assessed with the MDS-UPDRS, Hoehn and Yahr (HY), Clinical Impression Severity for PD, EQ-5D and PD Questionnaire - eight items (PDQ-8). Spearman's rank correlation coefficients, exploratory factor analysis and multiple linear regression models (dependent variables EQ-5D and PDQ-8) were performed. Results: The participants' age was 66.71 ± 10.32 years (51.5% men). PD duration was 8.52 ± 6.14, and median HY was 2 (range 1-5). The correlation between the EQ-5D index and the MDS-UPDRS ranged from -0.46 (Part IV) to -0.72 (Part II) and for the PDQ-8 index from 0.47 (Part III) to 0.74 (Part II). In multiple regression models with the MDS-UPDRS domains as independent variables, the main determinant for both the EQ-5D index and the PDQ-8 was Part II followed by Part I. After factorial grouping of the cardinal PD manifestations embedded in the MDS-UPDRS Parts III and IV for inclusion into multiple regression models, a factor formed by M-EDL, nM-EDL and fluctuations was the main determinant for both the EQ-5D and PDQ-8 indexes. Conclusions: The MDS-UPDRS component most tightly related with the HRQoL measures was a combination of motor and non-motor experiences of daily living.

Original languageEnglish (US)
Pages (from-to)519-524
Number of pages6
JournalEuropean Journal of Neurology
Issue number3
StatePublished - Mar 2014


  • EQ-5D
  • Health-related quality of life
  • Parkinson's disease
  • PDQ-8
  • Rating scales

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology


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