Relationship between the MDS-UPDRS and Quality of Life

A large multicenter study of 3206 patients

Matej Skorvanek, Pablo Martinez-Martin, Norbert Kovacs, Ivan Zezula, Mayela Rodriguez-Violante, Jean Christophe Corvol, Pille Taba, Klaus Seppi, Oleg Levin, Anette Schrag, Iciar Aviles-Olmos, Mario Alvarez-Sanchez, Tomoko Arakaki, Zsuzsanna Aschermann, Eve Benchetrit, Charline Benoit, Alberto Bergareche-Yarza, Amin Cervantes-Arriaga, Anabel Chade, Florence Cormier & 25 others Veronika Datieva, David A. Gallagher, Nelida Garretto, Zuzana Gdovinova, Oscar Gershanik, Milan Grofik, Vladimir Han, Liis Kadastik-Eerme, Monica M. Kurtis, Graziella Mangone, Juan Carlos Martinez-Castrillo, Amelia Mendoza-Rodriguez, Michal Minar, Henry P Moore, Mari Muldmaa, Christoph Mueller, Bernadette Pinter, Werner Poewe, Karin Rallmann, Eva Reiter, Carmen Rodriguez-Blazquez, Carlos Singer, Peter Valkovic, Christopher G. Goetz, Glenn T. Stebbins

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background: The relationship between Health-Related Quality of Life (HRQoL) and MDS-UPDRS has not been fully studied so far. The aim of this study was to evaluate the relationship between all MDS-UPDRS components and HRQoL in a representative international cohort of PD patients. Methods: We collected demographic and disease-related data as well as MDS-UPDRS and PDQ8 scales. Data were analyzed using correlations between PDQ8 and all MDS-UPDRS items, subsequently two hierarchical multiple regressions were performed, first between the scores of the MDS-UPDRS Parts and PDQ8 and second between individual items from those Parts demonstrating significant relationship to PDQ8 scores in the first regression. LASSO regression analyses were performed to evaluate the relationship between PDQ8 and all individual MDS-UPDRS items. Results: A total of 3206 PD patients were included in the study. In the first regression analysis, PDQ8 was significantly related to MDS-UPDRS parts I and II, but not to III and IV. In the second regression model, significant contributions to PDQ8 were found for Part I items Fatigue, Pain, Depressed mood, Apathy; and Part II items Dressing, Doing hobbies, Freezing, Speech and Tremor. In the LASSO analysis, six Part I, seven Part II, three Part III and one Part IV items contributed to PDQ8 scores. The five items most significantly related to the model were Depressed mood, Dressing, Apathy, Pain and Fatigue. Conclusions: This is so far the largest study related to HRQoL issues in PD. Restrictions in activities of daily living and non-motor symptoms significantly contribute to HRQoL in PD.

Original languageEnglish (US)
JournalParkinsonism and Related Disorders
DOIs
StateAccepted/In press - Jan 1 2018

Fingerprint

Multicenter Studies
Quality of Life
Apathy
Bandages
Fatigue
Regression Analysis
Hobbies
Pain
Tremor
Activities of Daily Living
Freezing
Demography

Keywords

  • Activities of daily living
  • MDS-UPDRS
  • Non-motor symptoms
  • Parkinson's disease
  • Quality of Life

ASJC Scopus subject areas

  • Neurology
  • Geriatrics and Gerontology
  • Clinical Neurology

Cite this

Skorvanek, M., Martinez-Martin, P., Kovacs, N., Zezula, I., Rodriguez-Violante, M., Corvol, J. C., ... Stebbins, G. T. (Accepted/In press). Relationship between the MDS-UPDRS and Quality of Life: A large multicenter study of 3206 patients. Parkinsonism and Related Disorders. https://doi.org/10.1016/j.parkreldis.2018.03.027

Relationship between the MDS-UPDRS and Quality of Life : A large multicenter study of 3206 patients. / Skorvanek, Matej; Martinez-Martin, Pablo; Kovacs, Norbert; Zezula, Ivan; Rodriguez-Violante, Mayela; Corvol, Jean Christophe; Taba, Pille; Seppi, Klaus; Levin, Oleg; Schrag, Anette; Aviles-Olmos, Iciar; Alvarez-Sanchez, Mario; Arakaki, Tomoko; Aschermann, Zsuzsanna; Benchetrit, Eve; Benoit, Charline; Bergareche-Yarza, Alberto; Cervantes-Arriaga, Amin; Chade, Anabel; Cormier, Florence; Datieva, Veronika; Gallagher, David A.; Garretto, Nelida; Gdovinova, Zuzana; Gershanik, Oscar; Grofik, Milan; Han, Vladimir; Kadastik-Eerme, Liis; Kurtis, Monica M.; Mangone, Graziella; Martinez-Castrillo, Juan Carlos; Mendoza-Rodriguez, Amelia; Minar, Michal; Moore, Henry P; Muldmaa, Mari; Mueller, Christoph; Pinter, Bernadette; Poewe, Werner; Rallmann, Karin; Reiter, Eva; Rodriguez-Blazquez, Carmen; Singer, Carlos; Valkovic, Peter; Goetz, Christopher G.; Stebbins, Glenn T.

In: Parkinsonism and Related Disorders, 01.01.2018.

Research output: Contribution to journalArticle

Skorvanek, M, Martinez-Martin, P, Kovacs, N, Zezula, I, Rodriguez-Violante, M, Corvol, JC, Taba, P, Seppi, K, Levin, O, Schrag, A, Aviles-Olmos, I, Alvarez-Sanchez, M, Arakaki, T, Aschermann, Z, Benchetrit, E, Benoit, C, Bergareche-Yarza, A, Cervantes-Arriaga, A, Chade, A, Cormier, F, Datieva, V, Gallagher, DA, Garretto, N, Gdovinova, Z, Gershanik, O, Grofik, M, Han, V, Kadastik-Eerme, L, Kurtis, MM, Mangone, G, Martinez-Castrillo, JC, Mendoza-Rodriguez, A, Minar, M, Moore, HP, Muldmaa, M, Mueller, C, Pinter, B, Poewe, W, Rallmann, K, Reiter, E, Rodriguez-Blazquez, C, Singer, C, Valkovic, P, Goetz, CG & Stebbins, GT 2018, 'Relationship between the MDS-UPDRS and Quality of Life: A large multicenter study of 3206 patients', Parkinsonism and Related Disorders. https://doi.org/10.1016/j.parkreldis.2018.03.027
Skorvanek, Matej ; Martinez-Martin, Pablo ; Kovacs, Norbert ; Zezula, Ivan ; Rodriguez-Violante, Mayela ; Corvol, Jean Christophe ; Taba, Pille ; Seppi, Klaus ; Levin, Oleg ; Schrag, Anette ; Aviles-Olmos, Iciar ; Alvarez-Sanchez, Mario ; Arakaki, Tomoko ; Aschermann, Zsuzsanna ; Benchetrit, Eve ; Benoit, Charline ; Bergareche-Yarza, Alberto ; Cervantes-Arriaga, Amin ; Chade, Anabel ; Cormier, Florence ; Datieva, Veronika ; Gallagher, David A. ; Garretto, Nelida ; Gdovinova, Zuzana ; Gershanik, Oscar ; Grofik, Milan ; Han, Vladimir ; Kadastik-Eerme, Liis ; Kurtis, Monica M. ; Mangone, Graziella ; Martinez-Castrillo, Juan Carlos ; Mendoza-Rodriguez, Amelia ; Minar, Michal ; Moore, Henry P ; Muldmaa, Mari ; Mueller, Christoph ; Pinter, Bernadette ; Poewe, Werner ; Rallmann, Karin ; Reiter, Eva ; Rodriguez-Blazquez, Carmen ; Singer, Carlos ; Valkovic, Peter ; Goetz, Christopher G. ; Stebbins, Glenn T. / Relationship between the MDS-UPDRS and Quality of Life : A large multicenter study of 3206 patients. In: Parkinsonism and Related Disorders. 2018.
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title = "Relationship between the MDS-UPDRS and Quality of Life: A large multicenter study of 3206 patients",
abstract = "Background: The relationship between Health-Related Quality of Life (HRQoL) and MDS-UPDRS has not been fully studied so far. The aim of this study was to evaluate the relationship between all MDS-UPDRS components and HRQoL in a representative international cohort of PD patients. Methods: We collected demographic and disease-related data as well as MDS-UPDRS and PDQ8 scales. Data were analyzed using correlations between PDQ8 and all MDS-UPDRS items, subsequently two hierarchical multiple regressions were performed, first between the scores of the MDS-UPDRS Parts and PDQ8 and second between individual items from those Parts demonstrating significant relationship to PDQ8 scores in the first regression. LASSO regression analyses were performed to evaluate the relationship between PDQ8 and all individual MDS-UPDRS items. Results: A total of 3206 PD patients were included in the study. In the first regression analysis, PDQ8 was significantly related to MDS-UPDRS parts I and II, but not to III and IV. In the second regression model, significant contributions to PDQ8 were found for Part I items Fatigue, Pain, Depressed mood, Apathy; and Part II items Dressing, Doing hobbies, Freezing, Speech and Tremor. In the LASSO analysis, six Part I, seven Part II, three Part III and one Part IV items contributed to PDQ8 scores. The five items most significantly related to the model were Depressed mood, Dressing, Apathy, Pain and Fatigue. Conclusions: This is so far the largest study related to HRQoL issues in PD. Restrictions in activities of daily living and non-motor symptoms significantly contribute to HRQoL in PD.",
keywords = "Activities of daily living, MDS-UPDRS, Non-motor symptoms, Parkinson's disease, Quality of Life",
author = "Matej Skorvanek and Pablo Martinez-Martin and Norbert Kovacs and Ivan Zezula and Mayela Rodriguez-Violante and Corvol, {Jean Christophe} and Pille Taba and Klaus Seppi and Oleg Levin and Anette Schrag and Iciar Aviles-Olmos and Mario Alvarez-Sanchez and Tomoko Arakaki and Zsuzsanna Aschermann and Eve Benchetrit and Charline Benoit and Alberto Bergareche-Yarza and Amin Cervantes-Arriaga and Anabel Chade and Florence Cormier and Veronika Datieva and Gallagher, {David A.} and Nelida Garretto and Zuzana Gdovinova and Oscar Gershanik and Milan Grofik and Vladimir Han and Liis Kadastik-Eerme and Kurtis, {Monica M.} and Graziella Mangone and Martinez-Castrillo, {Juan Carlos} and Amelia Mendoza-Rodriguez and Michal Minar and Moore, {Henry P} and Mari Muldmaa and Christoph Mueller and Bernadette Pinter and Werner Poewe and Karin Rallmann and Eva Reiter and Carmen Rodriguez-Blazquez and Carlos Singer and Peter Valkovic and Goetz, {Christopher G.} and Stebbins, {Glenn T.}",
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T1 - Relationship between the MDS-UPDRS and Quality of Life

T2 - A large multicenter study of 3206 patients

AU - Skorvanek, Matej

AU - Martinez-Martin, Pablo

AU - Kovacs, Norbert

AU - Zezula, Ivan

AU - Rodriguez-Violante, Mayela

AU - Corvol, Jean Christophe

AU - Taba, Pille

AU - Seppi, Klaus

AU - Levin, Oleg

AU - Schrag, Anette

AU - Aviles-Olmos, Iciar

AU - Alvarez-Sanchez, Mario

AU - Arakaki, Tomoko

AU - Aschermann, Zsuzsanna

AU - Benchetrit, Eve

AU - Benoit, Charline

AU - Bergareche-Yarza, Alberto

AU - Cervantes-Arriaga, Amin

AU - Chade, Anabel

AU - Cormier, Florence

AU - Datieva, Veronika

AU - Gallagher, David A.

AU - Garretto, Nelida

AU - Gdovinova, Zuzana

AU - Gershanik, Oscar

AU - Grofik, Milan

AU - Han, Vladimir

AU - Kadastik-Eerme, Liis

AU - Kurtis, Monica M.

AU - Mangone, Graziella

AU - Martinez-Castrillo, Juan Carlos

AU - Mendoza-Rodriguez, Amelia

AU - Minar, Michal

AU - Moore, Henry P

AU - Muldmaa, Mari

AU - Mueller, Christoph

AU - Pinter, Bernadette

AU - Poewe, Werner

AU - Rallmann, Karin

AU - Reiter, Eva

AU - Rodriguez-Blazquez, Carmen

AU - Singer, Carlos

AU - Valkovic, Peter

AU - Goetz, Christopher G.

AU - Stebbins, Glenn T.

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Background: The relationship between Health-Related Quality of Life (HRQoL) and MDS-UPDRS has not been fully studied so far. The aim of this study was to evaluate the relationship between all MDS-UPDRS components and HRQoL in a representative international cohort of PD patients. Methods: We collected demographic and disease-related data as well as MDS-UPDRS and PDQ8 scales. Data were analyzed using correlations between PDQ8 and all MDS-UPDRS items, subsequently two hierarchical multiple regressions were performed, first between the scores of the MDS-UPDRS Parts and PDQ8 and second between individual items from those Parts demonstrating significant relationship to PDQ8 scores in the first regression. LASSO regression analyses were performed to evaluate the relationship between PDQ8 and all individual MDS-UPDRS items. Results: A total of 3206 PD patients were included in the study. In the first regression analysis, PDQ8 was significantly related to MDS-UPDRS parts I and II, but not to III and IV. In the second regression model, significant contributions to PDQ8 were found for Part I items Fatigue, Pain, Depressed mood, Apathy; and Part II items Dressing, Doing hobbies, Freezing, Speech and Tremor. In the LASSO analysis, six Part I, seven Part II, three Part III and one Part IV items contributed to PDQ8 scores. The five items most significantly related to the model were Depressed mood, Dressing, Apathy, Pain and Fatigue. Conclusions: This is so far the largest study related to HRQoL issues in PD. Restrictions in activities of daily living and non-motor symptoms significantly contribute to HRQoL in PD.

AB - Background: The relationship between Health-Related Quality of Life (HRQoL) and MDS-UPDRS has not been fully studied so far. The aim of this study was to evaluate the relationship between all MDS-UPDRS components and HRQoL in a representative international cohort of PD patients. Methods: We collected demographic and disease-related data as well as MDS-UPDRS and PDQ8 scales. Data were analyzed using correlations between PDQ8 and all MDS-UPDRS items, subsequently two hierarchical multiple regressions were performed, first between the scores of the MDS-UPDRS Parts and PDQ8 and second between individual items from those Parts demonstrating significant relationship to PDQ8 scores in the first regression. LASSO regression analyses were performed to evaluate the relationship between PDQ8 and all individual MDS-UPDRS items. Results: A total of 3206 PD patients were included in the study. In the first regression analysis, PDQ8 was significantly related to MDS-UPDRS parts I and II, but not to III and IV. In the second regression model, significant contributions to PDQ8 were found for Part I items Fatigue, Pain, Depressed mood, Apathy; and Part II items Dressing, Doing hobbies, Freezing, Speech and Tremor. In the LASSO analysis, six Part I, seven Part II, three Part III and one Part IV items contributed to PDQ8 scores. The five items most significantly related to the model were Depressed mood, Dressing, Apathy, Pain and Fatigue. Conclusions: This is so far the largest study related to HRQoL issues in PD. Restrictions in activities of daily living and non-motor symptoms significantly contribute to HRQoL in PD.

KW - Activities of daily living

KW - MDS-UPDRS

KW - Non-motor symptoms

KW - Parkinson's disease

KW - Quality of Life

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DO - 10.1016/j.parkreldis.2018.03.027

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