Relationship between the Finnish Diabetes Risk Score (FINDRISC), vitamin D levels, and insulin resistance in obese subjects

Marcos M. Lima-Martínez, Carlos Arrau, Saimar Jerez, Mariela Paoli, Juan P. González-Rivas, Ramfis Nieto-Martínez, Gianluca Iacobellis

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Aim To assess the relationship between 25-hydroxyvitamin D [25(OH)D] blood concentrations in subjects with obesity and type 2 diabetes mellitus (T2D) risk according to the Finnish Diabetes Risk Score (FINDRISC) modified for Latin America (LA-FINDRISC). Methods This study was conducted in Ciudad Bolívar, Venezuela. Eighty two women and 20 men (53 obese and 49 nonobese), with an average age of 42.6 ± 12.30 years were enrolled. Weight, height, body mass index (BMI), waist circumference (WC), fasting glucose, basal insulin, plasma lipids, Homeostasis Model Assessment-Insulin Resistance (HOMA-IR), and 25(OH)D levels were measured. FINDRISC with WC cutoff points modified for Latin America was applied. Results No difference in 25(OH)D levels between obese and nonobese subjects was found. When anthropometric, clinical, and biochemical variables according to the 25(OH)D status were compared, the only difference detected was higher LA-FINDRISC in the insufficient/low 25(OH)D group compared to normal 25(OH)D levels group (12.75 ± 6.62; vs 10.15 ± 5.21; p = 0.031). LA-FINDRISC was negatively correlated with plasma 25(OH)D levels (r = −0.302; p = 0.002) and positively correlated with the HOMA-IR index (r = 0.637; p = 0.0001). Conclusions The LA-FINDRISC significantly correlated with both 25(OH)D levels and insulin resistance markers in this group of patients.

Original languageEnglish (US)
Pages (from-to)94-100
Number of pages7
JournalPrimary Care Diabetes
Volume11
Issue number1
DOIs
StatePublished - Feb 1 2017

Keywords

  • Findrisc
  • Insulin resistance
  • Obesity
  • Type 2 diabetes mellitus
  • Vitamin D

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

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