Relationship between serum lipid values and atherosclerotic burden in the proximal thoracic aorta

Shun Kohsaka, Zhezhen Jin, Tatjana Rundek, Shunichi Homma, Ralph L Sacco, Marco R. Di Tullio

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background: We conducted a cross-sectional analysis in a population-based cohort to compare the strength of the associations among various lipid parameters and the presence of atherosclerotic plaque in the proximal thoracic aorta. Methods: As part of Aortic Plaques and Risk of Ischemic Stroke (APRIS) study, 464 subjects were studied (mean age 69·1 ± 9·0, 251 males and 213 females), including 255 patients with first ischaemic stroke and 209 stroke-free controls. Presence and thickness of atherosclerotic plaque were assessed by transoesophageal echocardiography. Measured lipid parameters included total cholesterol, triglycerides, low-density lipoprotein, high-density lipoprotein, and non-high-density lipoprotein cholesterol, lipoprotein (a), apolipoprotein (Apo) B and A-I levels with their ratio. Results: Overall, atherosclerotic plaque was detected in 326 subjects (70·4%) and 37·6% of these subjects (n=174) had atherosclerotic plaque ≥4 mm. After adjusting for other significant predictors of atherosclerosis, high-density lipoprotein cholesterol level and Apo B/A-I ratio emerged as the strongest predictors of any atherosclerotic plaque (P<0·001 and P=0·004, respectively), followed by individual Apo B (P=0·015) and A-I (P=0·016) levels, triglycerides (P=0·027) and non-high-density lipoprotein cholesterol level (P=0·021). Total and low-density lipoprotein cholesterol levels were not significant predictors for any atherosclerotic plaque (P=0·273 and P=0·081, respectively). High-density lipoprotein cholesterol level (P=0·008) and Apo A-I (P=0·006) were also significant predictors of atherosclerotic plaque ≥4 mm. Similar trends were observed after exclusion of subjects on cholesterol lowering drugs. Conclusion: High-density lipoprotein cholesterol level and Apo B/A-I ratio, but not total or low-density lipoprotein cholesterol levels, were strongly associated with degree of proximal aortic atherosclerosis.

Original languageEnglish
Pages (from-to)257-263
Number of pages7
JournalInternational Journal of Stroke
Volume5
Issue number4
DOIs
StatePublished - Aug 1 2010

Fingerprint

Atherosclerotic Plaques
Thoracic Aorta
Lipids
Apolipoprotein A-I
Apolipoproteins B
Serum
LDL Cholesterol
HDL Cholesterol
Stroke
Atherosclerosis
Lipoprotein(a)
Transesophageal Echocardiography
HDL Lipoproteins
Triglycerides
Cross-Sectional Studies
Cholesterol
Pharmaceutical Preparations
Population

Keywords

  • Apolipoproteins
  • Atherosclerosis
  • Cardio-aortic embolism
  • Lipids
  • Risk factors

ASJC Scopus subject areas

  • Neurology

Cite this

Relationship between serum lipid values and atherosclerotic burden in the proximal thoracic aorta. / Kohsaka, Shun; Jin, Zhezhen; Rundek, Tatjana; Homma, Shunichi; Sacco, Ralph L; Di Tullio, Marco R.

In: International Journal of Stroke, Vol. 5, No. 4, 01.08.2010, p. 257-263.

Research output: Contribution to journalArticle

Kohsaka, Shun ; Jin, Zhezhen ; Rundek, Tatjana ; Homma, Shunichi ; Sacco, Ralph L ; Di Tullio, Marco R. / Relationship between serum lipid values and atherosclerotic burden in the proximal thoracic aorta. In: International Journal of Stroke. 2010 ; Vol. 5, No. 4. pp. 257-263.
@article{1943a1b98ddd492792c59a53dc9c63ee,
title = "Relationship between serum lipid values and atherosclerotic burden in the proximal thoracic aorta",
abstract = "Background: We conducted a cross-sectional analysis in a population-based cohort to compare the strength of the associations among various lipid parameters and the presence of atherosclerotic plaque in the proximal thoracic aorta. Methods: As part of Aortic Plaques and Risk of Ischemic Stroke (APRIS) study, 464 subjects were studied (mean age 69·1 ± 9·0, 251 males and 213 females), including 255 patients with first ischaemic stroke and 209 stroke-free controls. Presence and thickness of atherosclerotic plaque were assessed by transoesophageal echocardiography. Measured lipid parameters included total cholesterol, triglycerides, low-density lipoprotein, high-density lipoprotein, and non-high-density lipoprotein cholesterol, lipoprotein (a), apolipoprotein (Apo) B and A-I levels with their ratio. Results: Overall, atherosclerotic plaque was detected in 326 subjects (70·4{\%}) and 37·6{\%} of these subjects (n=174) had atherosclerotic plaque ≥4 mm. After adjusting for other significant predictors of atherosclerosis, high-density lipoprotein cholesterol level and Apo B/A-I ratio emerged as the strongest predictors of any atherosclerotic plaque (P<0·001 and P=0·004, respectively), followed by individual Apo B (P=0·015) and A-I (P=0·016) levels, triglycerides (P=0·027) and non-high-density lipoprotein cholesterol level (P=0·021). Total and low-density lipoprotein cholesterol levels were not significant predictors for any atherosclerotic plaque (P=0·273 and P=0·081, respectively). High-density lipoprotein cholesterol level (P=0·008) and Apo A-I (P=0·006) were also significant predictors of atherosclerotic plaque ≥4 mm. Similar trends were observed after exclusion of subjects on cholesterol lowering drugs. Conclusion: High-density lipoprotein cholesterol level and Apo B/A-I ratio, but not total or low-density lipoprotein cholesterol levels, were strongly associated with degree of proximal aortic atherosclerosis.",
keywords = "Apolipoproteins, Atherosclerosis, Cardio-aortic embolism, Lipids, Risk factors",
author = "Shun Kohsaka and Zhezhen Jin and Tatjana Rundek and Shunichi Homma and Sacco, {Ralph L} and {Di Tullio}, {Marco R.}",
year = "2010",
month = "8",
day = "1",
doi = "10.1111/j.1747-4949.2010.00437.x",
language = "English",
volume = "5",
pages = "257--263",
journal = "International Journal of Stroke",
issn = "1747-4930",
publisher = "Wiley-Blackwell",
number = "4",

}

TY - JOUR

T1 - Relationship between serum lipid values and atherosclerotic burden in the proximal thoracic aorta

AU - Kohsaka, Shun

AU - Jin, Zhezhen

AU - Rundek, Tatjana

AU - Homma, Shunichi

AU - Sacco, Ralph L

AU - Di Tullio, Marco R.

PY - 2010/8/1

Y1 - 2010/8/1

N2 - Background: We conducted a cross-sectional analysis in a population-based cohort to compare the strength of the associations among various lipid parameters and the presence of atherosclerotic plaque in the proximal thoracic aorta. Methods: As part of Aortic Plaques and Risk of Ischemic Stroke (APRIS) study, 464 subjects were studied (mean age 69·1 ± 9·0, 251 males and 213 females), including 255 patients with first ischaemic stroke and 209 stroke-free controls. Presence and thickness of atherosclerotic plaque were assessed by transoesophageal echocardiography. Measured lipid parameters included total cholesterol, triglycerides, low-density lipoprotein, high-density lipoprotein, and non-high-density lipoprotein cholesterol, lipoprotein (a), apolipoprotein (Apo) B and A-I levels with their ratio. Results: Overall, atherosclerotic plaque was detected in 326 subjects (70·4%) and 37·6% of these subjects (n=174) had atherosclerotic plaque ≥4 mm. After adjusting for other significant predictors of atherosclerosis, high-density lipoprotein cholesterol level and Apo B/A-I ratio emerged as the strongest predictors of any atherosclerotic plaque (P<0·001 and P=0·004, respectively), followed by individual Apo B (P=0·015) and A-I (P=0·016) levels, triglycerides (P=0·027) and non-high-density lipoprotein cholesterol level (P=0·021). Total and low-density lipoprotein cholesterol levels were not significant predictors for any atherosclerotic plaque (P=0·273 and P=0·081, respectively). High-density lipoprotein cholesterol level (P=0·008) and Apo A-I (P=0·006) were also significant predictors of atherosclerotic plaque ≥4 mm. Similar trends were observed after exclusion of subjects on cholesterol lowering drugs. Conclusion: High-density lipoprotein cholesterol level and Apo B/A-I ratio, but not total or low-density lipoprotein cholesterol levels, were strongly associated with degree of proximal aortic atherosclerosis.

AB - Background: We conducted a cross-sectional analysis in a population-based cohort to compare the strength of the associations among various lipid parameters and the presence of atherosclerotic plaque in the proximal thoracic aorta. Methods: As part of Aortic Plaques and Risk of Ischemic Stroke (APRIS) study, 464 subjects were studied (mean age 69·1 ± 9·0, 251 males and 213 females), including 255 patients with first ischaemic stroke and 209 stroke-free controls. Presence and thickness of atherosclerotic plaque were assessed by transoesophageal echocardiography. Measured lipid parameters included total cholesterol, triglycerides, low-density lipoprotein, high-density lipoprotein, and non-high-density lipoprotein cholesterol, lipoprotein (a), apolipoprotein (Apo) B and A-I levels with their ratio. Results: Overall, atherosclerotic plaque was detected in 326 subjects (70·4%) and 37·6% of these subjects (n=174) had atherosclerotic plaque ≥4 mm. After adjusting for other significant predictors of atherosclerosis, high-density lipoprotein cholesterol level and Apo B/A-I ratio emerged as the strongest predictors of any atherosclerotic plaque (P<0·001 and P=0·004, respectively), followed by individual Apo B (P=0·015) and A-I (P=0·016) levels, triglycerides (P=0·027) and non-high-density lipoprotein cholesterol level (P=0·021). Total and low-density lipoprotein cholesterol levels were not significant predictors for any atherosclerotic plaque (P=0·273 and P=0·081, respectively). High-density lipoprotein cholesterol level (P=0·008) and Apo A-I (P=0·006) were also significant predictors of atherosclerotic plaque ≥4 mm. Similar trends were observed after exclusion of subjects on cholesterol lowering drugs. Conclusion: High-density lipoprotein cholesterol level and Apo B/A-I ratio, but not total or low-density lipoprotein cholesterol levels, were strongly associated with degree of proximal aortic atherosclerosis.

KW - Apolipoproteins

KW - Atherosclerosis

KW - Cardio-aortic embolism

KW - Lipids

KW - Risk factors

UR - http://www.scopus.com/inward/record.url?scp=77955153615&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77955153615&partnerID=8YFLogxK

U2 - 10.1111/j.1747-4949.2010.00437.x

DO - 10.1111/j.1747-4949.2010.00437.x

M3 - Article

C2 - 20636707

AN - SCOPUS:77955153615

VL - 5

SP - 257

EP - 263

JO - International Journal of Stroke

JF - International Journal of Stroke

SN - 1747-4930

IS - 4

ER -