Relationship between osteofibrous dysplasia and adamantinoma

D. S. Springfield, A. E. Rosenberg, H. J. Mankin, E. R. Mindell

Research output: Contribution to journalArticlepeer-review

64 Scopus citations


The records and computer files of 32 patients treated at 1 institution for ossifying fibroma, fibrous dysplasia, osteofibrous dysplasia-like adamantinoma, or adamantinoma of the tibia were reviewed. Nineteen patients had their diagnosis changed, either because of a recurrence or through review of their histology. Six of the 9 patients who had a typical adamantinoma and 6 of the 10 patients who had an osteofibrous dysplasia-like adamantinoma had a diagnosis of 1 of the benign conditions before their adamantinoma was recognized. Only 6 patients actually had osteofibrous dysplasia. Three patients required a resection, but only 1 of the other 3 has been observed >5 years. This review suggests that many patients with a diagnosis of fibrous dysplasia or osteofibrous dysplasia of the tibia actually have an adamantinoma, and that osteofibrous dysplasia is often a locally aggressive lesion that progresses until it is widely resected. In addition. osteofibrous dysplasia and adamantinoma appear to be related, and osteofibrous dysplasia may be a precursor of adamantinoma.

Original languageEnglish (US)
Pages (from-to)234-244
Number of pages11
JournalClinical orthopaedics and related research
Issue number309
StatePublished - Jan 1 1994
Externally publishedYes

ASJC Scopus subject areas

  • Surgery
  • Orthopedics and Sports Medicine


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