Relationship between optic nerve protrusion measured by OCT and MRI and papilledema severity

Yu Cherng C Chang, Noam Alperin, Ahmet M. Bagci, Sang H. Lee, Potyra R. Rosa, Giovanni Gregori, Byron L Lam

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

PURPOSE. To develop measures of optic nerve protrusion length (NPL) from optical coherence tomography (OCT) and magnetic resonance imagining (MRI) and compare these measures with papilledema severity in idiopathic intracranial hypertension (IIH). METHODS. Optical coherence tomography and MRI scans were obtained from 11 newly diagnosed untreated IIH patients (30±10 years; body mass index [BMI] 36±4 kg/m<sup>2</sup>). Optic nerve protrusion length was measured for each eye using OCT and MRI independently. The relationship between the NPL measures and their association with the Frisen scale for papilledema severity were assessed. Two different OCT-based measures of NPL were derived to assess the influence of the retinal thickness on the association with papilledema severity. Additional OCT scans from 11 healthy subjects (38±7 years) were analyzed to establish reliability of the NPL measurement. RESULTS. Optical coherence tomography and MRI measurements of NPL were significantly linearly correlated (R = 0.79, P < 0.0001). Measurements of NPL from OCT and MRI were significantly associated with Frisen papilledema grade (P < 0.0001). Mean OCT measurement of NPL in the papilledema cohort was significantly larger than in the healthy cohort (0.62±0.24 vs. 0.09±0.03 mm, P < 0.0001). CONCLUSIONS. Significant linear correlation between OCT and MRI measurements of NPL supports the reliability of the OCT-based measurements of NPL in papilledema. Significant association between the papilledema grade and OCT- and MRI-based measurements of NPL highlights the potential of NPL as an objective and more sensitive marker of papilledema severity than the Frisen scale.

Original languageEnglish (US)
Pages (from-to)2297-2302
Number of pages6
JournalInvestigative Ophthalmology and Visual Science
Volume56
Issue number4
DOIs
StatePublished - 2015

Fingerprint

Papilledema
Optical Coherence Tomography
Optic Nerve
Magnetic Resonance Spectroscopy
Pseudotumor Cerebri
Healthy Volunteers
Body Mass Index

Keywords

  • MRI
  • Optic nerve protrusion
  • Optical coherence tomography
  • Papilledema

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience
  • Medicine(all)

Cite this

Relationship between optic nerve protrusion measured by OCT and MRI and papilledema severity. / Chang, Yu Cherng C; Alperin, Noam; Bagci, Ahmet M.; Lee, Sang H.; Rosa, Potyra R.; Gregori, Giovanni; Lam, Byron L.

In: Investigative Ophthalmology and Visual Science, Vol. 56, No. 4, 2015, p. 2297-2302.

Research output: Contribution to journalArticle

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title = "Relationship between optic nerve protrusion measured by OCT and MRI and papilledema severity",
abstract = "PURPOSE. To develop measures of optic nerve protrusion length (NPL) from optical coherence tomography (OCT) and magnetic resonance imagining (MRI) and compare these measures with papilledema severity in idiopathic intracranial hypertension (IIH). METHODS. Optical coherence tomography and MRI scans were obtained from 11 newly diagnosed untreated IIH patients (30±10 years; body mass index [BMI] 36±4 kg/m2). Optic nerve protrusion length was measured for each eye using OCT and MRI independently. The relationship between the NPL measures and their association with the Frisen scale for papilledema severity were assessed. Two different OCT-based measures of NPL were derived to assess the influence of the retinal thickness on the association with papilledema severity. Additional OCT scans from 11 healthy subjects (38±7 years) were analyzed to establish reliability of the NPL measurement. RESULTS. Optical coherence tomography and MRI measurements of NPL were significantly linearly correlated (R = 0.79, P < 0.0001). Measurements of NPL from OCT and MRI were significantly associated with Frisen papilledema grade (P < 0.0001). Mean OCT measurement of NPL in the papilledema cohort was significantly larger than in the healthy cohort (0.62±0.24 vs. 0.09±0.03 mm, P < 0.0001). CONCLUSIONS. Significant linear correlation between OCT and MRI measurements of NPL supports the reliability of the OCT-based measurements of NPL in papilledema. Significant association between the papilledema grade and OCT- and MRI-based measurements of NPL highlights the potential of NPL as an objective and more sensitive marker of papilledema severity than the Frisen scale.",
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AU - Chang, Yu Cherng C

AU - Alperin, Noam

AU - Bagci, Ahmet M.

AU - Lee, Sang H.

AU - Rosa, Potyra R.

AU - Gregori, Giovanni

AU - Lam, Byron L

PY - 2015

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N2 - PURPOSE. To develop measures of optic nerve protrusion length (NPL) from optical coherence tomography (OCT) and magnetic resonance imagining (MRI) and compare these measures with papilledema severity in idiopathic intracranial hypertension (IIH). METHODS. Optical coherence tomography and MRI scans were obtained from 11 newly diagnosed untreated IIH patients (30±10 years; body mass index [BMI] 36±4 kg/m2). Optic nerve protrusion length was measured for each eye using OCT and MRI independently. The relationship between the NPL measures and their association with the Frisen scale for papilledema severity were assessed. Two different OCT-based measures of NPL were derived to assess the influence of the retinal thickness on the association with papilledema severity. Additional OCT scans from 11 healthy subjects (38±7 years) were analyzed to establish reliability of the NPL measurement. RESULTS. Optical coherence tomography and MRI measurements of NPL were significantly linearly correlated (R = 0.79, P < 0.0001). Measurements of NPL from OCT and MRI were significantly associated with Frisen papilledema grade (P < 0.0001). Mean OCT measurement of NPL in the papilledema cohort was significantly larger than in the healthy cohort (0.62±0.24 vs. 0.09±0.03 mm, P < 0.0001). CONCLUSIONS. Significant linear correlation between OCT and MRI measurements of NPL supports the reliability of the OCT-based measurements of NPL in papilledema. Significant association between the papilledema grade and OCT- and MRI-based measurements of NPL highlights the potential of NPL as an objective and more sensitive marker of papilledema severity than the Frisen scale.

AB - PURPOSE. To develop measures of optic nerve protrusion length (NPL) from optical coherence tomography (OCT) and magnetic resonance imagining (MRI) and compare these measures with papilledema severity in idiopathic intracranial hypertension (IIH). METHODS. Optical coherence tomography and MRI scans were obtained from 11 newly diagnosed untreated IIH patients (30±10 years; body mass index [BMI] 36±4 kg/m2). Optic nerve protrusion length was measured for each eye using OCT and MRI independently. The relationship between the NPL measures and their association with the Frisen scale for papilledema severity were assessed. Two different OCT-based measures of NPL were derived to assess the influence of the retinal thickness on the association with papilledema severity. Additional OCT scans from 11 healthy subjects (38±7 years) were analyzed to establish reliability of the NPL measurement. RESULTS. Optical coherence tomography and MRI measurements of NPL were significantly linearly correlated (R = 0.79, P < 0.0001). Measurements of NPL from OCT and MRI were significantly associated with Frisen papilledema grade (P < 0.0001). Mean OCT measurement of NPL in the papilledema cohort was significantly larger than in the healthy cohort (0.62±0.24 vs. 0.09±0.03 mm, P < 0.0001). CONCLUSIONS. Significant linear correlation between OCT and MRI measurements of NPL supports the reliability of the OCT-based measurements of NPL in papilledema. Significant association between the papilledema grade and OCT- and MRI-based measurements of NPL highlights the potential of NPL as an objective and more sensitive marker of papilledema severity than the Frisen scale.

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KW - Optic nerve protrusion

KW - Optical coherence tomography

KW - Papilledema

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