Relationship between frequency dependence of lung compliance and distribution of ventilation

Adam Wanner, S. Zarzecki, N. Atkins, A. Zapata, M. A. Sackner

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The previously demonstrated empirical association between frequency dependence of lung compliance and distribution of ventilation, the latter determined by the N 2 washout technique, was confirmed by establishing a mathematical link between the 2 tests. By assuming a 2 compartment system with known compliances and making corrections for Pendelluft and common dead space mixing effects, the ratio of dynamic to static compliance (Cdyn/Cst) for any respiratory frequency can be calculated from the compartmental analysis of the N 2 washout at a single respiratory frequency. By using these equations, a good correlation was found between calculated and measured Cdyn/Cst in dogs with artificially induced bronchial obstruction and in young smokers or young nonsmokers after carbachol inhalation. A 2 compartment N 2 washout was demonstrated in 10 young healthy smokers at one or 2 respiratory frequencies whereas all 10 normal controls showed a single exponential curve. These findings indicate that the noninvasive N 2 washout test is capable of predicting Cdyn/Cst and at the same time gives a direct measure of gas distribution. Further, it appears to be a highly sensitive method for the detection of 'small airway disease'. (25 references.)

Original languageEnglish
Pages (from-to)1200-1213
Number of pages14
JournalJournal of Clinical Investigation
Volume54
Issue number5
StatePublished - Dec 1 1974

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Lung Compliance
Compliance
Ventilation
Carbachol
Inhalation
Gases
Dogs

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Relationship between frequency dependence of lung compliance and distribution of ventilation. / Wanner, Adam; Zarzecki, S.; Atkins, N.; Zapata, A.; Sackner, M. A.

In: Journal of Clinical Investigation, Vol. 54, No. 5, 01.12.1974, p. 1200-1213.

Research output: Contribution to journalArticle

Wanner, A, Zarzecki, S, Atkins, N, Zapata, A & Sackner, MA 1974, 'Relationship between frequency dependence of lung compliance and distribution of ventilation', Journal of Clinical Investigation, vol. 54, no. 5, pp. 1200-1213.
Wanner, Adam ; Zarzecki, S. ; Atkins, N. ; Zapata, A. ; Sackner, M. A. / Relationship between frequency dependence of lung compliance and distribution of ventilation. In: Journal of Clinical Investigation. 1974 ; Vol. 54, No. 5. pp. 1200-1213.
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