Relationship between frequency dependence of lung compliance and distribution of ventilation

A. Wanner, S. Zarzecki, N. Atkins, A. Zapata, M. A. Sackner

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

The previously demonstrated empirical association between frequency dependence of lung compliance and distribution of ventilation, the latter determined by the N 2 washout technique, was confirmed by establishing a mathematical link between the 2 tests. By assuming a 2 compartment system with known compliances and making corrections for Pendelluft and common dead space mixing effects, the ratio of dynamic to static compliance (Cdyn/Cst) for any respiratory frequency can be calculated from the compartmental analysis of the N 2 washout at a single respiratory frequency. By using these equations, a good correlation was found between calculated and measured Cdyn/Cst in dogs with artificially induced bronchial obstruction and in young smokers or young nonsmokers after carbachol inhalation. A 2 compartment N 2 washout was demonstrated in 10 young healthy smokers at one or 2 respiratory frequencies whereas all 10 normal controls showed a single exponential curve. These findings indicate that the noninvasive N 2 washout test is capable of predicting Cdyn/Cst and at the same time gives a direct measure of gas distribution. Further, it appears to be a highly sensitive method for the detection of 'small airway disease'. (25 references.)

Original languageEnglish (US)
Pages (from-to)1200-1213
Number of pages14
JournalUnknown Journal
Volume54
Issue number5
DOIs
StatePublished - 1974

ASJC Scopus subject areas

  • Medicine(all)

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