### Abstract

The previously demonstrated empirical association between frequency dependence of lung compliance and distribution of ventilation, the latter determined by the N _{2} washout technique, was confirmed by establishing a mathematical link between the 2 tests. By assuming a 2 compartment system with known compliances and making corrections for Pendelluft and common dead space mixing effects, the ratio of dynamic to static compliance (Cdyn/Cst) for any respiratory frequency can be calculated from the compartmental analysis of the N _{2} washout at a single respiratory frequency. By using these equations, a good correlation was found between calculated and measured Cdyn/Cst in dogs with artificially induced bronchial obstruction and in young smokers or young nonsmokers after carbachol inhalation. A 2 compartment N _{2} washout was demonstrated in 10 young healthy smokers at one or 2 respiratory frequencies whereas all 10 normal controls showed a single exponential curve. These findings indicate that the noninvasive N _{2} washout test is capable of predicting Cdyn/Cst and at the same time gives a direct measure of gas distribution. Further, it appears to be a highly sensitive method for the detection of 'small airway disease'. (25 references.)

Original language | English |
---|---|

Pages (from-to) | 1200-1213 |

Number of pages | 14 |

Journal | Journal of Clinical Investigation |

Volume | 54 |

Issue number | 5 |

State | Published - Dec 1 1974 |

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### ASJC Scopus subject areas

- Medicine(all)

### Cite this

*Journal of Clinical Investigation*,

*54*(5), 1200-1213.

**Relationship between frequency dependence of lung compliance and distribution of ventilation.** / Wanner, Adam; Zarzecki, S.; Atkins, N.; Zapata, A.; Sackner, M. A.

Research output: Contribution to journal › Article

*Journal of Clinical Investigation*, vol. 54, no. 5, pp. 1200-1213.

}

TY - JOUR

T1 - Relationship between frequency dependence of lung compliance and distribution of ventilation

AU - Wanner, Adam

AU - Zarzecki, S.

AU - Atkins, N.

AU - Zapata, A.

AU - Sackner, M. A.

PY - 1974/12/1

Y1 - 1974/12/1

N2 - The previously demonstrated empirical association between frequency dependence of lung compliance and distribution of ventilation, the latter determined by the N 2 washout technique, was confirmed by establishing a mathematical link between the 2 tests. By assuming a 2 compartment system with known compliances and making corrections for Pendelluft and common dead space mixing effects, the ratio of dynamic to static compliance (Cdyn/Cst) for any respiratory frequency can be calculated from the compartmental analysis of the N 2 washout at a single respiratory frequency. By using these equations, a good correlation was found between calculated and measured Cdyn/Cst in dogs with artificially induced bronchial obstruction and in young smokers or young nonsmokers after carbachol inhalation. A 2 compartment N 2 washout was demonstrated in 10 young healthy smokers at one or 2 respiratory frequencies whereas all 10 normal controls showed a single exponential curve. These findings indicate that the noninvasive N 2 washout test is capable of predicting Cdyn/Cst and at the same time gives a direct measure of gas distribution. Further, it appears to be a highly sensitive method for the detection of 'small airway disease'. (25 references.)

AB - The previously demonstrated empirical association between frequency dependence of lung compliance and distribution of ventilation, the latter determined by the N 2 washout technique, was confirmed by establishing a mathematical link between the 2 tests. By assuming a 2 compartment system with known compliances and making corrections for Pendelluft and common dead space mixing effects, the ratio of dynamic to static compliance (Cdyn/Cst) for any respiratory frequency can be calculated from the compartmental analysis of the N 2 washout at a single respiratory frequency. By using these equations, a good correlation was found between calculated and measured Cdyn/Cst in dogs with artificially induced bronchial obstruction and in young smokers or young nonsmokers after carbachol inhalation. A 2 compartment N 2 washout was demonstrated in 10 young healthy smokers at one or 2 respiratory frequencies whereas all 10 normal controls showed a single exponential curve. These findings indicate that the noninvasive N 2 washout test is capable of predicting Cdyn/Cst and at the same time gives a direct measure of gas distribution. Further, it appears to be a highly sensitive method for the detection of 'small airway disease'. (25 references.)

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M3 - Article

VL - 54

SP - 1200

EP - 1213

JO - Journal of Clinical Investigation

JF - Journal of Clinical Investigation

SN - 0021-9738

IS - 5

ER -