Relationship between cingulo-insular functional connectivity and autistic traits in neurotypical adults

Adriana Di Martino, Zarrar Shehzad, Clare Kelly, Amy Krain Roy, Dylan G. Gee, Lucina Q Uddin, Kristin Gotimer, Donald F. Klein, F. Xavier Castellanos, Michael P. Milham

Research output: Contribution to journalArticle

152 Citations (Scopus)

Abstract

Objective: The Social Responsiveness Scale - Adult Version (SRS-A) measures autistic traits that are continuously distributed in the general population. Based on increased recognition of the dimensional nature of autistic traits, the authors examined the neural correlates of these traits in neurotypical individuals using the SRSA and established a novel approach to assessing the neural basis of autistic characteristics, attempting to directly relate SRSA scores to patterns of functional connectivity observed in the pregenual anterior cingulate cortex, a region commonly implicated in social cognition. Methods: Resting state functional magnetic resonance imaging scans were collected for 25 neurotypical adults. All participants provided SRS-A ratings completed by an informant who had observed them in natural social settings. Whole brain-corrected connectivity analyses were then conducted using SRS-A scores as a covariate of interest. Results: Across participants, a significant negative relationship between SRS-A scores and the functional connectivity of the pregenual anterior cingulate cortex with the anterior portion of the mid-insula was found. Specifically, low levels of autistic traits were observed when a substantial portion of the anterior mid-insula showed positive connectivity with the pregenual anterior cingulate cortex. In contrast, elevated levels of autistic traits were associated with negative connectivity between these two regions. Conclusions: Resting state functional connectivity of the pregenual anterior cingulate cortex-insula social network was related to autistic traits in neurotypical adults. Application of this approach in samples with autism spectrum disorders is needed to confirm whether this circuit is dimensionally related to the severity of autistic traits in clinical populations.

Original languageEnglish (US)
Pages (from-to)891-899
Number of pages9
JournalAmerican Journal of Psychiatry
Volume166
Issue number8
DOIs
StatePublished - 2009
Externally publishedYes

Fingerprint

Gyrus Cinguli
Social Support
Cognition
Population
Magnetic Resonance Imaging
Brain

ASJC Scopus subject areas

  • Medicine(all)
  • Psychiatry and Mental health

Cite this

Relationship between cingulo-insular functional connectivity and autistic traits in neurotypical adults. / Di Martino, Adriana; Shehzad, Zarrar; Kelly, Clare; Roy, Amy Krain; Gee, Dylan G.; Uddin, Lucina Q; Gotimer, Kristin; Klein, Donald F.; Castellanos, F. Xavier; Milham, Michael P.

In: American Journal of Psychiatry, Vol. 166, No. 8, 2009, p. 891-899.

Research output: Contribution to journalArticle

Di Martino, A, Shehzad, Z, Kelly, C, Roy, AK, Gee, DG, Uddin, LQ, Gotimer, K, Klein, DF, Castellanos, FX & Milham, MP 2009, 'Relationship between cingulo-insular functional connectivity and autistic traits in neurotypical adults', American Journal of Psychiatry, vol. 166, no. 8, pp. 891-899. https://doi.org/10.1176/appi.ajp.2009.08121894
Di Martino, Adriana ; Shehzad, Zarrar ; Kelly, Clare ; Roy, Amy Krain ; Gee, Dylan G. ; Uddin, Lucina Q ; Gotimer, Kristin ; Klein, Donald F. ; Castellanos, F. Xavier ; Milham, Michael P. / Relationship between cingulo-insular functional connectivity and autistic traits in neurotypical adults. In: American Journal of Psychiatry. 2009 ; Vol. 166, No. 8. pp. 891-899.
@article{8df78d682466485dbeb89fda44640299,
title = "Relationship between cingulo-insular functional connectivity and autistic traits in neurotypical adults",
abstract = "Objective: The Social Responsiveness Scale - Adult Version (SRS-A) measures autistic traits that are continuously distributed in the general population. Based on increased recognition of the dimensional nature of autistic traits, the authors examined the neural correlates of these traits in neurotypical individuals using the SRSA and established a novel approach to assessing the neural basis of autistic characteristics, attempting to directly relate SRSA scores to patterns of functional connectivity observed in the pregenual anterior cingulate cortex, a region commonly implicated in social cognition. Methods: Resting state functional magnetic resonance imaging scans were collected for 25 neurotypical adults. All participants provided SRS-A ratings completed by an informant who had observed them in natural social settings. Whole brain-corrected connectivity analyses were then conducted using SRS-A scores as a covariate of interest. Results: Across participants, a significant negative relationship between SRS-A scores and the functional connectivity of the pregenual anterior cingulate cortex with the anterior portion of the mid-insula was found. Specifically, low levels of autistic traits were observed when a substantial portion of the anterior mid-insula showed positive connectivity with the pregenual anterior cingulate cortex. In contrast, elevated levels of autistic traits were associated with negative connectivity between these two regions. Conclusions: Resting state functional connectivity of the pregenual anterior cingulate cortex-insula social network was related to autistic traits in neurotypical adults. Application of this approach in samples with autism spectrum disorders is needed to confirm whether this circuit is dimensionally related to the severity of autistic traits in clinical populations.",
author = "{Di Martino}, Adriana and Zarrar Shehzad and Clare Kelly and Roy, {Amy Krain} and Gee, {Dylan G.} and Uddin, {Lucina Q} and Kristin Gotimer and Klein, {Donald F.} and Castellanos, {F. Xavier} and Milham, {Michael P.}",
year = "2009",
doi = "10.1176/appi.ajp.2009.08121894",
language = "English (US)",
volume = "166",
pages = "891--899",
journal = "American Journal of Psychiatry",
issn = "0002-953X",
publisher = "American Psychiatric Association",
number = "8",

}

TY - JOUR

T1 - Relationship between cingulo-insular functional connectivity and autistic traits in neurotypical adults

AU - Di Martino, Adriana

AU - Shehzad, Zarrar

AU - Kelly, Clare

AU - Roy, Amy Krain

AU - Gee, Dylan G.

AU - Uddin, Lucina Q

AU - Gotimer, Kristin

AU - Klein, Donald F.

AU - Castellanos, F. Xavier

AU - Milham, Michael P.

PY - 2009

Y1 - 2009

N2 - Objective: The Social Responsiveness Scale - Adult Version (SRS-A) measures autistic traits that are continuously distributed in the general population. Based on increased recognition of the dimensional nature of autistic traits, the authors examined the neural correlates of these traits in neurotypical individuals using the SRSA and established a novel approach to assessing the neural basis of autistic characteristics, attempting to directly relate SRSA scores to patterns of functional connectivity observed in the pregenual anterior cingulate cortex, a region commonly implicated in social cognition. Methods: Resting state functional magnetic resonance imaging scans were collected for 25 neurotypical adults. All participants provided SRS-A ratings completed by an informant who had observed them in natural social settings. Whole brain-corrected connectivity analyses were then conducted using SRS-A scores as a covariate of interest. Results: Across participants, a significant negative relationship between SRS-A scores and the functional connectivity of the pregenual anterior cingulate cortex with the anterior portion of the mid-insula was found. Specifically, low levels of autistic traits were observed when a substantial portion of the anterior mid-insula showed positive connectivity with the pregenual anterior cingulate cortex. In contrast, elevated levels of autistic traits were associated with negative connectivity between these two regions. Conclusions: Resting state functional connectivity of the pregenual anterior cingulate cortex-insula social network was related to autistic traits in neurotypical adults. Application of this approach in samples with autism spectrum disorders is needed to confirm whether this circuit is dimensionally related to the severity of autistic traits in clinical populations.

AB - Objective: The Social Responsiveness Scale - Adult Version (SRS-A) measures autistic traits that are continuously distributed in the general population. Based on increased recognition of the dimensional nature of autistic traits, the authors examined the neural correlates of these traits in neurotypical individuals using the SRSA and established a novel approach to assessing the neural basis of autistic characteristics, attempting to directly relate SRSA scores to patterns of functional connectivity observed in the pregenual anterior cingulate cortex, a region commonly implicated in social cognition. Methods: Resting state functional magnetic resonance imaging scans were collected for 25 neurotypical adults. All participants provided SRS-A ratings completed by an informant who had observed them in natural social settings. Whole brain-corrected connectivity analyses were then conducted using SRS-A scores as a covariate of interest. Results: Across participants, a significant negative relationship between SRS-A scores and the functional connectivity of the pregenual anterior cingulate cortex with the anterior portion of the mid-insula was found. Specifically, low levels of autistic traits were observed when a substantial portion of the anterior mid-insula showed positive connectivity with the pregenual anterior cingulate cortex. In contrast, elevated levels of autistic traits were associated with negative connectivity between these two regions. Conclusions: Resting state functional connectivity of the pregenual anterior cingulate cortex-insula social network was related to autistic traits in neurotypical adults. Application of this approach in samples with autism spectrum disorders is needed to confirm whether this circuit is dimensionally related to the severity of autistic traits in clinical populations.

UR - http://www.scopus.com/inward/record.url?scp=68149141820&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=68149141820&partnerID=8YFLogxK

U2 - 10.1176/appi.ajp.2009.08121894

DO - 10.1176/appi.ajp.2009.08121894

M3 - Article

C2 - 19605539

AN - SCOPUS:68149141820

VL - 166

SP - 891

EP - 899

JO - American Journal of Psychiatry

JF - American Journal of Psychiatry

SN - 0002-953X

IS - 8

ER -