Relationship between ambulatory blood pressure and aortic arch atherosclerosis

Shinichi Iwata, Zhezhen Jin, Joseph E. Schwartz, Shunichi Homma, Mitchell S V Elkind, Tatjana Rundek, Ralph L Sacco, Marco R. Di Tullio

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Objective: Atherosclerotic plaque in the aortic arch is an independent risk factor for ischemic stroke. Although high blood pressure (BP) measured at the doctor's office is known to be associated with aortic atherosclerosis, little is known on the association between 24-h ambulatory BP and aortic arch plaque presence and severity. Our objective was to clarify the association between ambulatory BP variables and aortic arch atherosclerosis in a community-based cohort. Methods: The study population consisted of 795 patients (mean age 71. ±. 9 years) participating in the Cardiovascular Abnormalities and Brain Lesions (CABL) study who underwent 24-h ambulatory BP monitoring (ABPM). Arch plaque was evaluated by 2D transthoracic echocardiography from a suprasternal window. Results: All systolic ABPM variables (24-h/daytime/nighttime mean systolic BP, daytime/nighttime systolic BP variability) were associated with the presence of any plaque and large (≥4. mm) plaque, whereas diastolic BP variables were not associated with aortic atherosclerosis. Multiple regression analysis indicated that nighttime systolic BP variability (expressed as the standard deviation of nighttime systolic BP) remained independently associated with large plaque after adjustment for age, sex, cigarette smoking, history of hypertension, diabetes mellitus, hypercholesterolemia, anti-hypertensive medication and nighttime mean systolic BP (odds ratio 1.39 per 1 standard deviation increase, 95% CI 1.00-1.93, P<. 0.05). Conclusion: Systolic ABPM variables are significantly associated with the presence of arch plaque. Nighttime systolic BP variability is independently associated with large arch plaque. These findings may have important implications in gaining further insights into the mechanism of arch plaque formation and progression.

Original languageEnglish
Pages (from-to)427-431
Number of pages5
JournalAtherosclerosis
Volume221
Issue number2
DOIs
StatePublished - Apr 1 2012

Fingerprint

Thoracic Aorta
Atherosclerosis
Blood Pressure
Ambulatory Monitoring
Echocardiography
Cardiovascular Abnormalities
Hypertension
Ambulatory Blood Pressure Monitoring
Atherosclerotic Plaques
Hypercholesterolemia
Antihypertensive Agents
Diabetes Mellitus

Keywords

  • Ambulatory blood pressure
  • Aortic arch atherosclerosis
  • Blood pressure variability

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Iwata, S., Jin, Z., Schwartz, J. E., Homma, S., Elkind, M. S. V., Rundek, T., ... Di Tullio, M. R. (2012). Relationship between ambulatory blood pressure and aortic arch atherosclerosis. Atherosclerosis, 221(2), 427-431. https://doi.org/10.1016/j.atherosclerosis.2012.01.010

Relationship between ambulatory blood pressure and aortic arch atherosclerosis. / Iwata, Shinichi; Jin, Zhezhen; Schwartz, Joseph E.; Homma, Shunichi; Elkind, Mitchell S V; Rundek, Tatjana; Sacco, Ralph L; Di Tullio, Marco R.

In: Atherosclerosis, Vol. 221, No. 2, 01.04.2012, p. 427-431.

Research output: Contribution to journalArticle

Iwata, S, Jin, Z, Schwartz, JE, Homma, S, Elkind, MSV, Rundek, T, Sacco, RL & Di Tullio, MR 2012, 'Relationship between ambulatory blood pressure and aortic arch atherosclerosis', Atherosclerosis, vol. 221, no. 2, pp. 427-431. https://doi.org/10.1016/j.atherosclerosis.2012.01.010
Iwata, Shinichi ; Jin, Zhezhen ; Schwartz, Joseph E. ; Homma, Shunichi ; Elkind, Mitchell S V ; Rundek, Tatjana ; Sacco, Ralph L ; Di Tullio, Marco R. / Relationship between ambulatory blood pressure and aortic arch atherosclerosis. In: Atherosclerosis. 2012 ; Vol. 221, No. 2. pp. 427-431.
@article{d94d29e60e51445ca4c0abdeef7ac055,
title = "Relationship between ambulatory blood pressure and aortic arch atherosclerosis",
abstract = "Objective: Atherosclerotic plaque in the aortic arch is an independent risk factor for ischemic stroke. Although high blood pressure (BP) measured at the doctor's office is known to be associated with aortic atherosclerosis, little is known on the association between 24-h ambulatory BP and aortic arch plaque presence and severity. Our objective was to clarify the association between ambulatory BP variables and aortic arch atherosclerosis in a community-based cohort. Methods: The study population consisted of 795 patients (mean age 71. ±. 9 years) participating in the Cardiovascular Abnormalities and Brain Lesions (CABL) study who underwent 24-h ambulatory BP monitoring (ABPM). Arch plaque was evaluated by 2D transthoracic echocardiography from a suprasternal window. Results: All systolic ABPM variables (24-h/daytime/nighttime mean systolic BP, daytime/nighttime systolic BP variability) were associated with the presence of any plaque and large (≥4. mm) plaque, whereas diastolic BP variables were not associated with aortic atherosclerosis. Multiple regression analysis indicated that nighttime systolic BP variability (expressed as the standard deviation of nighttime systolic BP) remained independently associated with large plaque after adjustment for age, sex, cigarette smoking, history of hypertension, diabetes mellitus, hypercholesterolemia, anti-hypertensive medication and nighttime mean systolic BP (odds ratio 1.39 per 1 standard deviation increase, 95{\%} CI 1.00-1.93, P<. 0.05). Conclusion: Systolic ABPM variables are significantly associated with the presence of arch plaque. Nighttime systolic BP variability is independently associated with large arch plaque. These findings may have important implications in gaining further insights into the mechanism of arch plaque formation and progression.",
keywords = "Ambulatory blood pressure, Aortic arch atherosclerosis, Blood pressure variability",
author = "Shinichi Iwata and Zhezhen Jin and Schwartz, {Joseph E.} and Shunichi Homma and Elkind, {Mitchell S V} and Tatjana Rundek and Sacco, {Ralph L} and {Di Tullio}, {Marco R.}",
year = "2012",
month = "4",
day = "1",
doi = "10.1016/j.atherosclerosis.2012.01.010",
language = "English",
volume = "221",
pages = "427--431",
journal = "Atherosclerosis",
issn = "0021-9150",
publisher = "Elsevier Ireland Ltd",
number = "2",

}

TY - JOUR

T1 - Relationship between ambulatory blood pressure and aortic arch atherosclerosis

AU - Iwata, Shinichi

AU - Jin, Zhezhen

AU - Schwartz, Joseph E.

AU - Homma, Shunichi

AU - Elkind, Mitchell S V

AU - Rundek, Tatjana

AU - Sacco, Ralph L

AU - Di Tullio, Marco R.

PY - 2012/4/1

Y1 - 2012/4/1

N2 - Objective: Atherosclerotic plaque in the aortic arch is an independent risk factor for ischemic stroke. Although high blood pressure (BP) measured at the doctor's office is known to be associated with aortic atherosclerosis, little is known on the association between 24-h ambulatory BP and aortic arch plaque presence and severity. Our objective was to clarify the association between ambulatory BP variables and aortic arch atherosclerosis in a community-based cohort. Methods: The study population consisted of 795 patients (mean age 71. ±. 9 years) participating in the Cardiovascular Abnormalities and Brain Lesions (CABL) study who underwent 24-h ambulatory BP monitoring (ABPM). Arch plaque was evaluated by 2D transthoracic echocardiography from a suprasternal window. Results: All systolic ABPM variables (24-h/daytime/nighttime mean systolic BP, daytime/nighttime systolic BP variability) were associated with the presence of any plaque and large (≥4. mm) plaque, whereas diastolic BP variables were not associated with aortic atherosclerosis. Multiple regression analysis indicated that nighttime systolic BP variability (expressed as the standard deviation of nighttime systolic BP) remained independently associated with large plaque after adjustment for age, sex, cigarette smoking, history of hypertension, diabetes mellitus, hypercholesterolemia, anti-hypertensive medication and nighttime mean systolic BP (odds ratio 1.39 per 1 standard deviation increase, 95% CI 1.00-1.93, P<. 0.05). Conclusion: Systolic ABPM variables are significantly associated with the presence of arch plaque. Nighttime systolic BP variability is independently associated with large arch plaque. These findings may have important implications in gaining further insights into the mechanism of arch plaque formation and progression.

AB - Objective: Atherosclerotic plaque in the aortic arch is an independent risk factor for ischemic stroke. Although high blood pressure (BP) measured at the doctor's office is known to be associated with aortic atherosclerosis, little is known on the association between 24-h ambulatory BP and aortic arch plaque presence and severity. Our objective was to clarify the association between ambulatory BP variables and aortic arch atherosclerosis in a community-based cohort. Methods: The study population consisted of 795 patients (mean age 71. ±. 9 years) participating in the Cardiovascular Abnormalities and Brain Lesions (CABL) study who underwent 24-h ambulatory BP monitoring (ABPM). Arch plaque was evaluated by 2D transthoracic echocardiography from a suprasternal window. Results: All systolic ABPM variables (24-h/daytime/nighttime mean systolic BP, daytime/nighttime systolic BP variability) were associated with the presence of any plaque and large (≥4. mm) plaque, whereas diastolic BP variables were not associated with aortic atherosclerosis. Multiple regression analysis indicated that nighttime systolic BP variability (expressed as the standard deviation of nighttime systolic BP) remained independently associated with large plaque after adjustment for age, sex, cigarette smoking, history of hypertension, diabetes mellitus, hypercholesterolemia, anti-hypertensive medication and nighttime mean systolic BP (odds ratio 1.39 per 1 standard deviation increase, 95% CI 1.00-1.93, P<. 0.05). Conclusion: Systolic ABPM variables are significantly associated with the presence of arch plaque. Nighttime systolic BP variability is independently associated with large arch plaque. These findings may have important implications in gaining further insights into the mechanism of arch plaque formation and progression.

KW - Ambulatory blood pressure

KW - Aortic arch atherosclerosis

KW - Blood pressure variability

UR - http://www.scopus.com/inward/record.url?scp=84858703734&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84858703734&partnerID=8YFLogxK

U2 - 10.1016/j.atherosclerosis.2012.01.010

DO - 10.1016/j.atherosclerosis.2012.01.010

M3 - Article

C2 - 22296886

AN - SCOPUS:84858703734

VL - 221

SP - 427

EP - 431

JO - Atherosclerosis

JF - Atherosclerosis

SN - 0021-9150

IS - 2

ER -