Abstract
This study explores by means of statistical modeling the relations between adrenocorticotrophin hormone (ACTH) and Cortisol levels and distribution and function of peripheral blood cells in response to an acute stressor consisting of a standardized speech task in breast cancer patients with axillary lymphnode metastases and distant metastases. As a control group age-matched women participated in this study. The preliminary findings show that the effect of ACTH on imrrmnoreacrivity is related to the health of the donor. In node-positive breast cancer patients and healthy women, ACTH has a modest positive effect on T lymphocyte percentages and on pokeweedinduced proliferation at baseline and in response to the speech task. In contrast, in breast cancer patients with distant metastases ACTH has a negative effect on T lymphocyte percentages and function at baseline and in response to the stressor. Interestingly, neither ACTH nor Cortisol levels were related to natural killer (NK) cell percentages and natural killer cell activity (NKCA). In addition, it appeared that Cortisol had a positive effect on CD3 cell percentages when the health of the donor was taken into account. This effect was most distinct on CD3 cells measured at baseline. If replicated on a larger scale, these findings may indicate that the hypothalamic pituitary adrenal axis plays a role in the adaptation of the host defenses in reaction to acute stress, particularly those involving T lymphocytes. Moreover, these findings may suggest that the health of the donor may be an important effect modification factor in the relations between neuroendocrines and immunoreacttvity.
| Original language | English |
|---|---|
| Pages (from-to) | 145-169 |
| Number of pages | 25 |
| Journal | International Journal of Behavioral Medicine |
| Volume | 4 |
| Issue number | 2 |
| DOIs | |
| State | Published - Jun 1 1997 |
Fingerprint
Keywords
- adrenocorticotrophin hormone (ACTH)
- breast cancer
- Cortisol
- immunoreactivity
- statistical modelin
ASJC Scopus subject areas
- Clinical Psychology
- Psychology(all)
Cite this
Relations of plasma acth and cortisol levels with the distribution and function of peripheral blood cells in response to a behavioral challenge in breast cancer : An empirical exploration by means of statistical modeling. / van der Pompe, Gieta; Antoni, Michael H; Duivenvoorden, Hugo J.; Heijnen, Cobi J.
In: International Journal of Behavioral Medicine, Vol. 4, No. 2, 01.06.1997, p. 145-169.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Relations of plasma acth and cortisol levels with the distribution and function of peripheral blood cells in response to a behavioral challenge in breast cancer
T2 - An empirical exploration by means of statistical modeling
AU - van der Pompe, Gieta
AU - Antoni, Michael H
AU - Duivenvoorden, Hugo J.
AU - Heijnen, Cobi J.
PY - 1997/6/1
Y1 - 1997/6/1
N2 - This study explores by means of statistical modeling the relations between adrenocorticotrophin hormone (ACTH) and Cortisol levels and distribution and function of peripheral blood cells in response to an acute stressor consisting of a standardized speech task in breast cancer patients with axillary lymphnode metastases and distant metastases. As a control group age-matched women participated in this study. The preliminary findings show that the effect of ACTH on imrrmnoreacrivity is related to the health of the donor. In node-positive breast cancer patients and healthy women, ACTH has a modest positive effect on T lymphocyte percentages and on pokeweedinduced proliferation at baseline and in response to the speech task. In contrast, in breast cancer patients with distant metastases ACTH has a negative effect on T lymphocyte percentages and function at baseline and in response to the stressor. Interestingly, neither ACTH nor Cortisol levels were related to natural killer (NK) cell percentages and natural killer cell activity (NKCA). In addition, it appeared that Cortisol had a positive effect on CD3 cell percentages when the health of the donor was taken into account. This effect was most distinct on CD3 cells measured at baseline. If replicated on a larger scale, these findings may indicate that the hypothalamic pituitary adrenal axis plays a role in the adaptation of the host defenses in reaction to acute stress, particularly those involving T lymphocytes. Moreover, these findings may suggest that the health of the donor may be an important effect modification factor in the relations between neuroendocrines and immunoreacttvity.
AB - This study explores by means of statistical modeling the relations between adrenocorticotrophin hormone (ACTH) and Cortisol levels and distribution and function of peripheral blood cells in response to an acute stressor consisting of a standardized speech task in breast cancer patients with axillary lymphnode metastases and distant metastases. As a control group age-matched women participated in this study. The preliminary findings show that the effect of ACTH on imrrmnoreacrivity is related to the health of the donor. In node-positive breast cancer patients and healthy women, ACTH has a modest positive effect on T lymphocyte percentages and on pokeweedinduced proliferation at baseline and in response to the speech task. In contrast, in breast cancer patients with distant metastases ACTH has a negative effect on T lymphocyte percentages and function at baseline and in response to the stressor. Interestingly, neither ACTH nor Cortisol levels were related to natural killer (NK) cell percentages and natural killer cell activity (NKCA). In addition, it appeared that Cortisol had a positive effect on CD3 cell percentages when the health of the donor was taken into account. This effect was most distinct on CD3 cells measured at baseline. If replicated on a larger scale, these findings may indicate that the hypothalamic pituitary adrenal axis plays a role in the adaptation of the host defenses in reaction to acute stress, particularly those involving T lymphocytes. Moreover, these findings may suggest that the health of the donor may be an important effect modification factor in the relations between neuroendocrines and immunoreacttvity.
KW - adrenocorticotrophin hormone (ACTH)
KW - breast cancer
KW - Cortisol
KW - immunoreactivity
KW - statistical modelin
UR - http://www.scopus.com/inward/record.url?scp=0012285674&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0012285674&partnerID=8YFLogxK
U2 - 10.1207/s15327558ijbm0402_4
DO - 10.1207/s15327558ijbm0402_4
M3 - Article
C2 - 16250736
AN - SCOPUS:0012285674
VL - 4
SP - 145
EP - 169
JO - International Journal of Behavioral Medicine
JF - International Journal of Behavioral Medicine
SN - 1070-5503
IS - 2
ER -