Relation of Subepicardial Adipose Tissue to Carotid Intima-Media Thickness in Patients With Human Immunodeficiency Virus

Gianluca Iacobellis, Adriano M. Pellicelli, Arya M. Sharma, Benvenuto Grisorio, Giorgio Barbarini, Giuseppe Barbaro

Research output: Contribution to journalArticle

75 Citations (Scopus)

Abstract

Patients infected with human immunodeficiency virus (HIV) are at increased risk for subclinical atherosclerosis. Whether increased cardiac adiposity may be related to HIV subclinical atherosclerosis is still unexplored. The objective of this study was to evaluate whether echocardiographically determined subepicardial adipose tissue, an index of cardiac adiposity, is related to carotid intima-media thickness (IMT), an index of subclinical atherosclerosis, in HIV-infected patients receiving highly active antiretroviral therapy. Echocardiographic epicardial fat thickness and ultrasonographic IMT were measured in 103 consecutive HIV-infected Caucasian subjects receiving highly active antiretroviral therapy. Echocardiographic subepicardial adipose tissue showed an excellent correlation with IMT (r = 0.92, p <0.01). Multiple regression analysis showed that IMT was best predicted by epicardial fat thickness (r2 = 0.81, p <0.01). In conclusion, this study suggests, for the first time, that epicardial adipose tissue, an index of cardiac adiposity, may be significantly related to subclinical atherosclerosis in HIV-infected patients.

Original languageEnglish
Pages (from-to)1470-1472
Number of pages3
JournalAmerican Journal of Cardiology
Volume99
Issue number10
DOIs
StatePublished - May 15 2007
Externally publishedYes

Fingerprint

Carotid Intima-Media Thickness
Adipose Tissue
HIV
Atherosclerosis
Adiposity
Highly Active Antiretroviral Therapy
Fats
Regression Analysis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Relation of Subepicardial Adipose Tissue to Carotid Intima-Media Thickness in Patients With Human Immunodeficiency Virus. / Iacobellis, Gianluca; Pellicelli, Adriano M.; Sharma, Arya M.; Grisorio, Benvenuto; Barbarini, Giorgio; Barbaro, Giuseppe.

In: American Journal of Cardiology, Vol. 99, No. 10, 15.05.2007, p. 1470-1472.

Research output: Contribution to journalArticle

Iacobellis, Gianluca ; Pellicelli, Adriano M. ; Sharma, Arya M. ; Grisorio, Benvenuto ; Barbarini, Giorgio ; Barbaro, Giuseppe. / Relation of Subepicardial Adipose Tissue to Carotid Intima-Media Thickness in Patients With Human Immunodeficiency Virus. In: American Journal of Cardiology. 2007 ; Vol. 99, No. 10. pp. 1470-1472.
@article{5e5624a5ffda4a8398e78c103ae732b2,
title = "Relation of Subepicardial Adipose Tissue to Carotid Intima-Media Thickness in Patients With Human Immunodeficiency Virus",
abstract = "Patients infected with human immunodeficiency virus (HIV) are at increased risk for subclinical atherosclerosis. Whether increased cardiac adiposity may be related to HIV subclinical atherosclerosis is still unexplored. The objective of this study was to evaluate whether echocardiographically determined subepicardial adipose tissue, an index of cardiac adiposity, is related to carotid intima-media thickness (IMT), an index of subclinical atherosclerosis, in HIV-infected patients receiving highly active antiretroviral therapy. Echocardiographic epicardial fat thickness and ultrasonographic IMT were measured in 103 consecutive HIV-infected Caucasian subjects receiving highly active antiretroviral therapy. Echocardiographic subepicardial adipose tissue showed an excellent correlation with IMT (r = 0.92, p <0.01). Multiple regression analysis showed that IMT was best predicted by epicardial fat thickness (r2 = 0.81, p <0.01). In conclusion, this study suggests, for the first time, that epicardial adipose tissue, an index of cardiac adiposity, may be significantly related to subclinical atherosclerosis in HIV-infected patients.",
author = "Gianluca Iacobellis and Pellicelli, {Adriano M.} and Sharma, {Arya M.} and Benvenuto Grisorio and Giorgio Barbarini and Giuseppe Barbaro",
year = "2007",
month = "5",
day = "15",
doi = "10.1016/j.amjcard.2006.12.082",
language = "English",
volume = "99",
pages = "1470--1472",
journal = "American Journal of Cardiology",
issn = "0002-9149",
publisher = "Elsevier Inc.",
number = "10",

}

TY - JOUR

T1 - Relation of Subepicardial Adipose Tissue to Carotid Intima-Media Thickness in Patients With Human Immunodeficiency Virus

AU - Iacobellis, Gianluca

AU - Pellicelli, Adriano M.

AU - Sharma, Arya M.

AU - Grisorio, Benvenuto

AU - Barbarini, Giorgio

AU - Barbaro, Giuseppe

PY - 2007/5/15

Y1 - 2007/5/15

N2 - Patients infected with human immunodeficiency virus (HIV) are at increased risk for subclinical atherosclerosis. Whether increased cardiac adiposity may be related to HIV subclinical atherosclerosis is still unexplored. The objective of this study was to evaluate whether echocardiographically determined subepicardial adipose tissue, an index of cardiac adiposity, is related to carotid intima-media thickness (IMT), an index of subclinical atherosclerosis, in HIV-infected patients receiving highly active antiretroviral therapy. Echocardiographic epicardial fat thickness and ultrasonographic IMT were measured in 103 consecutive HIV-infected Caucasian subjects receiving highly active antiretroviral therapy. Echocardiographic subepicardial adipose tissue showed an excellent correlation with IMT (r = 0.92, p <0.01). Multiple regression analysis showed that IMT was best predicted by epicardial fat thickness (r2 = 0.81, p <0.01). In conclusion, this study suggests, for the first time, that epicardial adipose tissue, an index of cardiac adiposity, may be significantly related to subclinical atherosclerosis in HIV-infected patients.

AB - Patients infected with human immunodeficiency virus (HIV) are at increased risk for subclinical atherosclerosis. Whether increased cardiac adiposity may be related to HIV subclinical atherosclerosis is still unexplored. The objective of this study was to evaluate whether echocardiographically determined subepicardial adipose tissue, an index of cardiac adiposity, is related to carotid intima-media thickness (IMT), an index of subclinical atherosclerosis, in HIV-infected patients receiving highly active antiretroviral therapy. Echocardiographic epicardial fat thickness and ultrasonographic IMT were measured in 103 consecutive HIV-infected Caucasian subjects receiving highly active antiretroviral therapy. Echocardiographic subepicardial adipose tissue showed an excellent correlation with IMT (r = 0.92, p <0.01). Multiple regression analysis showed that IMT was best predicted by epicardial fat thickness (r2 = 0.81, p <0.01). In conclusion, this study suggests, for the first time, that epicardial adipose tissue, an index of cardiac adiposity, may be significantly related to subclinical atherosclerosis in HIV-infected patients.

UR - http://www.scopus.com/inward/record.url?scp=34247590944&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34247590944&partnerID=8YFLogxK

U2 - 10.1016/j.amjcard.2006.12.082

DO - 10.1016/j.amjcard.2006.12.082

M3 - Article

VL - 99

SP - 1470

EP - 1472

JO - American Journal of Cardiology

JF - American Journal of Cardiology

SN - 0002-9149

IS - 10

ER -