Relation of kidney tissue somatomedin-c/insulin-like growth factor i to postnephrectomy renal growth in the rat

Alan D. Stiles; Ilene R.S. Sosenko; Barry T. Smith; Alan D. Stiles; A. Joseph D’ercole

doi:10.1210/endo-117-6-2397

Relation of kidney tissue somatomedin-c/insulin-like growth factor i to postnephrectomy renal growth in the rat

Alan D. Stiles, Ilene R.S. Sosenko, Barry T. Smith, Alan D. Stiles, A. Joseph D’ercole

Pediatrics

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Abstract

In kidney tissue extracts, we observed elevated somatomedin-C (SmC) tissue concentrations in the kidney remaining after nephrectomy compared to those in the kidney removed at surgery of kidneys from sham-operated animals. In hypophysectomized animals, we observed a response of the same magnitude, but brom significantly lowered basal SmC concentrations. In neither case did nephrectomy affect SmC levels in serum or other tissues studied (liver and lung). The increased tissue levels of SmC in the regenerating kidney, with a return to baseline levels within 30 days, along with the absence of elevated serum levels suggest a local role for this mitogen in organ growth.

Original language	English (US)
Pages (from-to)	2397-2401
Number of pages	5
Journal	Endocrinology
Volume	117
Issue number	6
DOIs	https://doi.org/10.1210/endo-117-6-2397
State	Published - 1985

ASJC Scopus subject areas

Endocrinology

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AU - Stiles, Alan D.

AU - D’ercole, A. Joseph

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AB - In kidney tissue extracts, we observed elevated somatomedin-C (SmC) tissue concentrations in the kidney remaining after nephrectomy compared to those in the kidney removed at surgery of kidneys from sham-operated animals. In hypophysectomized animals, we observed a response of the same magnitude, but brom significantly lowered basal SmC concentrations. In neither case did nephrectomy affect SmC levels in serum or other tissues studied (liver and lung). The increased tissue levels of SmC in the regenerating kidney, with a return to baseline levels within 30 days, along with the absence of elevated serum levels suggest a local role for this mitogen in organ growth.

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Relation of kidney tissue somatomedin-c/insulin-like growth factor i to postnephrectomy renal growth in the rat

Abstract

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