Relation of kidney tissue somatomedin-c/insulin-like growth factor i to postnephrectomy renal growth in the rat

Alan D. Stiles; Ilene R.S. Sosenko; Barry T. Smith; Alan D. Stiles; A. Joseph D’ercole

doi:10.1210/endo-117-6-2397

Relation of kidney tissue somatomedin-c/insulin-like growth factor i to postnephrectomy renal growth in the rat

Alan D. Stiles, Ilene R.S. Sosenko, Barry T. Smith, Alan D. Stiles, A. Joseph D’ercole

Pediatrics

Research output: Contribution to journal › Article

99 Scopus citations

Abstract

In kidney tissue extracts, we observed elevated somatomedin-C (SmC) tissue concentrations in the kidney remaining after nephrectomy compared to those in the kidney removed at surgery of kidneys from sham-operated animals. In hypophysectomized animals, we observed a response of the same magnitude, but brom significantly lowered basal SmC concentrations. In neither case did nephrectomy affect SmC levels in serum or other tissues studied (liver and lung). The increased tissue levels of SmC in the regenerating kidney, with a return to baseline levels within 30 days, along with the absence of elevated serum levels suggest a local role for this mitogen in organ growth.

Original language	English (US)
Pages (from-to)	2397-2401
Number of pages	5
Journal	Endocrinology
Volume	117
Issue number	6
DOIs	https://doi.org/10.1210/endo-117-6-2397
State	Published - Jan 1 1985

Fingerprint

ASJC Scopus subject areas

Endocrinology

Cite this

Stiles, A. D., Sosenko, I. R. S., Smith, B. T., Stiles, A. D., & D’ercole, A. J. (1985). Relation of kidney tissue somatomedin-c/insulin-like growth factor i to postnephrectomy renal growth in the rat. Endocrinology, 117(6), 2397-2401. https://doi.org/10.1210/endo-117-6-2397

@article{3bc787ab364047dbbab92e6001527156,

title = "Relation of kidney tissue somatomedin-c/insulin-like growth factor i to postnephrectomy renal growth in the rat",

abstract = "In kidney tissue extracts, we observed elevated somatomedin-C (SmC) tissue concentrations in the kidney remaining after nephrectomy compared to those in the kidney removed at surgery of kidneys from sham-operated animals. In hypophysectomized animals, we observed a response of the same magnitude, but brom significantly lowered basal SmC concentrations. In neither case did nephrectomy affect SmC levels in serum or other tissues studied (liver and lung). The increased tissue levels of SmC in the regenerating kidney, with a return to baseline levels within 30 days, along with the absence of elevated serum levels suggest a local role for this mitogen in organ growth.",

author = "Stiles, {Alan D.} and Sosenko, {Ilene R.S.} and Smith, {Barry T.} and Stiles, {Alan D.} and D{\textquoteright}ercole, {A. Joseph}",

year = "1985",

month = jan

day = "1",

doi = "10.1210/endo-117-6-2397",

language = "English (US)",

volume = "117",

pages = "2397--2401",

journal = "Endocrinology",

issn = "0013-7227",

publisher = "The Endocrine Society",

number = "6",

}

TY - JOUR

T1 - Relation of kidney tissue somatomedin-c/insulin-like growth factor i to postnephrectomy renal growth in the rat

AU - Stiles, Alan D.

AU - Sosenko, Ilene R.S.

AU - Smith, Barry T.

AU - Stiles, Alan D.

AU - D’ercole, A. Joseph

PY - 1985/1/1

Y1 - 1985/1/1

N2 - In kidney tissue extracts, we observed elevated somatomedin-C (SmC) tissue concentrations in the kidney remaining after nephrectomy compared to those in the kidney removed at surgery of kidneys from sham-operated animals. In hypophysectomized animals, we observed a response of the same magnitude, but brom significantly lowered basal SmC concentrations. In neither case did nephrectomy affect SmC levels in serum or other tissues studied (liver and lung). The increased tissue levels of SmC in the regenerating kidney, with a return to baseline levels within 30 days, along with the absence of elevated serum levels suggest a local role for this mitogen in organ growth.

AB - In kidney tissue extracts, we observed elevated somatomedin-C (SmC) tissue concentrations in the kidney remaining after nephrectomy compared to those in the kidney removed at surgery of kidneys from sham-operated animals. In hypophysectomized animals, we observed a response of the same magnitude, but brom significantly lowered basal SmC concentrations. In neither case did nephrectomy affect SmC levels in serum or other tissues studied (liver and lung). The increased tissue levels of SmC in the regenerating kidney, with a return to baseline levels within 30 days, along with the absence of elevated serum levels suggest a local role for this mitogen in organ growth.

UR - http://www.scopus.com/inward/record.url?scp=0022342311&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022342311&partnerID=8YFLogxK

U2 - 10.1210/endo-117-6-2397

DO - 10.1210/endo-117-6-2397

M3 - Article

C2 - 4065038

AN - SCOPUS:0022342311

VL - 117

SP - 2397

EP - 2401

JO - Endocrinology

JF - Endocrinology

SN - 0013-7227

IS - 6

ER -

Access to Document

10.1210/endo-117-6-2397