Relation of Diabetes to Cognitive Function in Hispanics/Latinos of Diverse Backgrounds in the United States

Tali Elfassy, Allison E. Aiello, Neil Schneiderman, Mary N. Haan, Wassim Tarraf, Hector M. González, Marc Gellman, Hermes J Florez, Jose A. Luchsinger, Clinton B Wright, Ellen Grober, Adina Zeki Al Hazzouri

Research output: Contribution to journalArticle

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Objectives:To examine the association between diabetes and cognitive function within U.S. Hispanics/Latinos of Central American, Cuban, Dominican, Mexican, Puerto Rican, and South American background. Method: This cross-sectional study included 9,609 men and women (mean age = 56.5 years), who are members of the Hispanic Community Health Study/Study of Latinos. We classified participants as having diabetes, prediabetes, or normal glucose regulation. Participants underwent a neurocognitive battery consisting of tests of verbal fluency, delayed recall, and processing speed. Analyses were stratified by Hispanic/Latino subgroup. Results: From fully adjusted linear regression models, compared with having normal glucose regulation, having diabetes was associated with worse processing speed among Cubans (β = −1.99; 95% CI [confidence interval] = [−3.80, −0.19]) and Mexicans (β = −2.26; 95% CI = [−4.02, −0.51]). Compared with having normal glucose regulation, having prediabetes or diabetes was associated with worse delayed recall only among Mexicans (prediabetes: β = −0.34; 95% CI = [−0.63, −0.05] and diabetes: β = −0.41; 95% CI = [−0.79, −0.04]). No associations with verbal fluency. Discussion: The relationship between diabetes and cognitive function varied across Hispanic/Latino subgroup.

Original languageEnglish (US)
JournalJournal of Aging and Health
StateAccepted/In press - Mar 1 2018



  • cognitive aging
  • diabetes
  • epidemiology
  • Hispanics/Latinos
  • minority aging

ASJC Scopus subject areas

  • Gerontology
  • Community and Home Care
  • Geriatrics and Gerontology

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