TY - JOUR
T1 - Relation of Diabetes to Cognitive Function in Hispanics/Latinos of Diverse Backgrounds in the United States
AU - Elfassy, Tali
AU - Aiello, Allison E.
AU - Schneiderman, Neil
AU - Haan, Mary N.
AU - Tarraf, Wassim
AU - González, Hector M.
AU - Gellman, Marc
AU - Florez, Hermes J.
AU - Luchsinger, Jose A.
AU - Wright, Clinton B.
AU - Grober, Ellen
AU - Zeki Al Hazzouri, Adina
N1 - Funding Information:
The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This study was funded by the U.S. National Institutes of Health (NIH), National Institute on Aging (Grant K01 AG047273); the NIH, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK; Grant R01 DK087864); the NIH, National Heart, Lung, and Blood Institute (NHLBI; Grant HL 007426); and American Heart Association (Grant 17POST32490000). The Hispanic Community Health Study/Study of Latinos was carried out as a collaborative study supported by contracts from the NHLBI to the University of North Carolina (Grant N01 HC65233), University of Miami (Grant N01 HC65234), Albert Einstein College of Medicine (Grant N01 HC65235), Northwestern University (Grant N01 HC65236), and San Diego State University (Grant N01 HC65237). The sponsors had no role in the design or conduct of the study; collection, management, analysis, or interpretation of the data; or the preparation, review, or approval of the manuscript.
PY - 2019/8/1
Y1 - 2019/8/1
N2 - Objectives:To examine the association between diabetes and cognitive function within U.S. Hispanics/Latinos of Central American, Cuban, Dominican, Mexican, Puerto Rican, and South American background. Method: This cross-sectional study included 9,609 men and women (mean age = 56.5 years), who are members of the Hispanic Community Health Study/Study of Latinos. We classified participants as having diabetes, prediabetes, or normal glucose regulation. Participants underwent a neurocognitive battery consisting of tests of verbal fluency, delayed recall, and processing speed. Analyses were stratified by Hispanic/Latino subgroup. Results: From fully adjusted linear regression models, compared with having normal glucose regulation, having diabetes was associated with worse processing speed among Cubans (β = −1.99; 95% CI [confidence interval] = [−3.80, −0.19]) and Mexicans (β = −2.26; 95% CI = [−4.02, −0.51]). Compared with having normal glucose regulation, having prediabetes or diabetes was associated with worse delayed recall only among Mexicans (prediabetes: β = −0.34; 95% CI = [−0.63, −0.05] and diabetes: β = −0.41; 95% CI = [−0.79, −0.04]). No associations with verbal fluency. Discussion: The relationship between diabetes and cognitive function varied across Hispanic/Latino subgroup.
AB - Objectives:To examine the association between diabetes and cognitive function within U.S. Hispanics/Latinos of Central American, Cuban, Dominican, Mexican, Puerto Rican, and South American background. Method: This cross-sectional study included 9,609 men and women (mean age = 56.5 years), who are members of the Hispanic Community Health Study/Study of Latinos. We classified participants as having diabetes, prediabetes, or normal glucose regulation. Participants underwent a neurocognitive battery consisting of tests of verbal fluency, delayed recall, and processing speed. Analyses were stratified by Hispanic/Latino subgroup. Results: From fully adjusted linear regression models, compared with having normal glucose regulation, having diabetes was associated with worse processing speed among Cubans (β = −1.99; 95% CI [confidence interval] = [−3.80, −0.19]) and Mexicans (β = −2.26; 95% CI = [−4.02, −0.51]). Compared with having normal glucose regulation, having prediabetes or diabetes was associated with worse delayed recall only among Mexicans (prediabetes: β = −0.34; 95% CI = [−0.63, −0.05] and diabetes: β = −0.41; 95% CI = [−0.79, −0.04]). No associations with verbal fluency. Discussion: The relationship between diabetes and cognitive function varied across Hispanic/Latino subgroup.
KW - Hispanics/Latinos
KW - cognitive aging
KW - diabetes
KW - epidemiology
KW - minority aging
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U2 - 10.1177/0898264318759379
DO - 10.1177/0898264318759379
M3 - Article
C2 - 29577792
AN - SCOPUS:85044571812
VL - 31
SP - 1155
EP - 1171
JO - Journal of Aging and Health
JF - Journal of Aging and Health
SN - 0898-2643
IS - 7
ER -