Relation of CSF neurotensin concentrations to symptoms and drug response of psychotic patients

David L. Garver, Garth Bissette, Jeffrey K. Yao, Charles Nemeroff

Research output: Contribution to journalArticle

98 Citations (Scopus)

Abstract

Objective: The authors investigated the putative endogenous antipsychotic neurotensin in relation to both psychotic symptoms and patterns of response during treatment with an antipsychotic drug. Method: Twenty recently admitted patients with mood-incongruent psychoses underwent 1) interviews with the Schedule for Affective Disorders and Schizophrenia for diagnostic evaluation and symptom profiles, 2) drug-free baseline measurements of CSF neurotensin and homovanillic acid, and 3) close monitoring of a therapeutic trial of haloperidol to determine latency of antipsychotic response. Results: A relative deficiency in CSF neurotensin was found in a subgroup of psychotic women whose clinical response to haloperidol was delayed for 11 to 35 days after initiation of the neuroleptic. These patients had greater thought disorder, delusions-hallucinations, behavioral disorganization, and impaired functioning than did psychotic patients with higher CSF concentrations of neurotensin. Neurotensin concentrations increased during treatment with haloperidol. Conclusions: The study provides further evidence that there is diminished availability of neurotensin in some psychotic patients, with increases in neurotensin early in neuroleptic treatment. Exploration of neurotensin receptor agonists as a potentially novel class of antipsychotic compounds is suggested.

Original languageEnglish
Pages (from-to)484-488
Number of pages5
JournalAmerican Journal of Psychiatry
Volume148
Issue number4
StatePublished - Apr 1 1991
Externally publishedYes

Fingerprint

Neurotensin
Antipsychotic Agents
Pharmaceutical Preparations
Haloperidol
Neurotensin Receptors
Homovanillic Acid
Delusions
Symptom Assessment
Hallucinations
Therapeutics
Mood Disorders
Psychotic Disorders
Reaction Time
Schizophrenia
Appointments and Schedules
Interviews

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Relation of CSF neurotensin concentrations to symptoms and drug response of psychotic patients. / Garver, David L.; Bissette, Garth; Yao, Jeffrey K.; Nemeroff, Charles.

In: American Journal of Psychiatry, Vol. 148, No. 4, 01.04.1991, p. 484-488.

Research output: Contribution to journalArticle

Garver, David L. ; Bissette, Garth ; Yao, Jeffrey K. ; Nemeroff, Charles. / Relation of CSF neurotensin concentrations to symptoms and drug response of psychotic patients. In: American Journal of Psychiatry. 1991 ; Vol. 148, No. 4. pp. 484-488.
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