Relation between choice of partner and high frequency of connexin-26 deafness

Walter E. Nance, Xue Z Liu, Arti Pandya

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

Recessive mutations at the connexin-26 gene locus are now recognised as the cause of nearly half of all cases of genetic deafness in many populations. We suggest that this high frequency is only seen in populations with a long tradition of intermarriage among deaf people. Available data are consistent with the hypothesis that such marriages might well have contributed to the high frequency of connexin-26 deafness in the USA, and could represent a novel mechanism for maintaining specific genotypes at unexpectedly high frequencies.

Original languageEnglish
Pages (from-to)500-501
Number of pages2
JournalLancet
Volume356
Issue number9228
StatePublished - Aug 5 2000
Externally publishedYes

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Deafness
Marriage
Population
Genotype
Mutation
Genes
Connexin 26

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Relation between choice of partner and high frequency of connexin-26 deafness. / Nance, Walter E.; Liu, Xue Z; Pandya, Arti.

In: Lancet, Vol. 356, No. 9228, 05.08.2000, p. 500-501.

Research output: Contribution to journalArticle

Nance, WE, Liu, XZ & Pandya, A 2000, 'Relation between choice of partner and high frequency of connexin-26 deafness', Lancet, vol. 356, no. 9228, pp. 500-501.
Nance, Walter E. ; Liu, Xue Z ; Pandya, Arti. / Relation between choice of partner and high frequency of connexin-26 deafness. In: Lancet. 2000 ; Vol. 356, No. 9228. pp. 500-501.
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