Relation between choice of partner and high frequency of connexin-26 deafness

Walter E. Nance, Xue Zhong Liu, Arti Pandya

Research output: Contribution to journalComment/debate

54 Scopus citations

Abstract

Recessive mutations at the connexin-26 gene locus are now recognised as the cause of nearly half of all cases of genetic deafness in many populations. We suggest that this high frequency is only seen in populations with a long tradition of intermarriage among deaf people. Available data are consistent with the hypothesis that such marriages might well have contributed to the high frequency of connexin-26 deafness in the USA, and could represent a novel mechanism for maintaining specific genotypes at unexpectedly high frequencies.

Original languageEnglish (US)
Pages (from-to)500-501
Number of pages2
JournalLancet
Volume356
Issue number9228
DOIs
StatePublished - Aug 5 2000
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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