Relation between ascending aortic pressures and outcomes in patients with angiographically demonstrated coronary artery disease

Julio A. Chirinos, Juan P. Zambrano, Simon Chakko, Anila Veerani, Alan Schob, Guido Perez, Armando J. Mendez

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Abstract

We prospectively followed 324 men, who underwent coronary angiography, for 1,161 ± 418 days. We analyzed the association between ascending aortic pressures measured during cardiac catheterization and the risk of all-cause mortality and a combined end point of major adverse cardiovascular events (MACEs), including unstable angina pectoris, myocardial infarction, coronary revascularization, stroke, or death. Pulse pressure significantly predicted MACEs (hazard ratio [HR] per 10 mm Hg increase 1.09, 95% confidence interval [CI] 1.002 to 1.17, p = 0.04). Diastolic blood pressure (BP) inversely correlated with the risk of MACEs (HR per 10 mm Hg increase 0.85, 95% CI 0.74 to 0.98, p = 0.02). These correlations remained significant after adjusting for other predictors and potential confounders. The association between lower diastolic BP with the risk of MACEs was more pronounced in patients with triple-vessel coronary artery disease (p for interaction = 0.03). Peripheral diastolic BP (but not pulse pressure) correlated inversely with the risk of MACEs (HR 0.87 per 10 mm Hg increase, 95% CI 0.75 to 0.998, p = 0.047). Aortic pulse pressure significantly predicted death (HR per 10 mm Hg increase 1.18, 95% CI 1.05 to 1.33, p = 0.004), and aortic diastolic BP correlated inversely with the risk of death (HR 0.76, 95% CI 0.62 to 0.94, p = 0.01).

Original languageEnglish (US)
Pages (from-to)645-648
Number of pages4
JournalAmerican Journal of Cardiology
Volume96
Issue number5
DOIs
StatePublished - Sep 1 2005

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ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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