Relation between 20-year income volatility and brain health in midlife: The CARDIA study

Leslie Grasset, M. Maria Glymour, Tali Elfassy, Samuel L. Swift, Kristine Yaffe, Archana Singh-Manoux, Adina Zeki Al Hazzouri

Research output: Contribution to journalArticle

Abstract

OBJECTIVE: Income volatility presents a growing public health threat. To our knowledge, no previous study examined the relationship among income volatility, cognitive function, and brain integrity. METHODS: We studied 3,287 participants aged 23-35 years in 1990 from the Coronary Artery Risk Development in Young Adults prospective cohort study. Income volatility data were created using income data collected from 1990 to 2010 and defined as SD of percent change in income and number of income drops ≥25% (categorized as 0, 1, or 2+). In 2010, cognitive tests (n = 3,287) and brain scans (n = 716) were obtained. RESULTS: After covariate adjustment, higher income volatility was associated with worse performance on processing speed (β = -1.09, 95% confidence interval [CI] -1.73 to -0.44) and executive functioning (β = 2.53, 95% CI 0.60-4.50) but not on verbal memory (β = -0.02, 95% CI -0.16 to 0.11). Similarly, additional income drops were associated with worse performance on processing speed and executive functioning. Higher income volatility and more income drops were also associated with worse microstructural integrity of total brain and total white matter. All findings were similar when restricted to those with high education, suggesting reverse causation may not explain these findings. CONCLUSION: Income volatility over a 20-year period of formative earning years was associated with worse cognitive function and brain integrity in midlife.

Original languageEnglish (US)
Pages (from-to)e1890-e1899
JournalNeurology
Volume93
Issue number20
DOIs
StatePublished - Nov 12 2019

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Volatilization
Health
Brain
Confidence Intervals
Cognition
Social Adjustment
Causality
Young Adult
Coronary Vessels
Cohort Studies
Public Health
Prospective Studies

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Grasset, L., Glymour, M. M., Elfassy, T., Swift, S. L., Yaffe, K., Singh-Manoux, A., & Zeki Al Hazzouri, A. (2019). Relation between 20-year income volatility and brain health in midlife: The CARDIA study. Neurology, 93(20), e1890-e1899. https://doi.org/10.1212/WNL.0000000000008463

Relation between 20-year income volatility and brain health in midlife : The CARDIA study. / Grasset, Leslie; Glymour, M. Maria; Elfassy, Tali; Swift, Samuel L.; Yaffe, Kristine; Singh-Manoux, Archana; Zeki Al Hazzouri, Adina.

In: Neurology, Vol. 93, No. 20, 12.11.2019, p. e1890-e1899.

Research output: Contribution to journalArticle

Grasset, L, Glymour, MM, Elfassy, T, Swift, SL, Yaffe, K, Singh-Manoux, A & Zeki Al Hazzouri, A 2019, 'Relation between 20-year income volatility and brain health in midlife: The CARDIA study', Neurology, vol. 93, no. 20, pp. e1890-e1899. https://doi.org/10.1212/WNL.0000000000008463
Grasset L, Glymour MM, Elfassy T, Swift SL, Yaffe K, Singh-Manoux A et al. Relation between 20-year income volatility and brain health in midlife: The CARDIA study. Neurology. 2019 Nov 12;93(20):e1890-e1899. https://doi.org/10.1212/WNL.0000000000008463
Grasset, Leslie ; Glymour, M. Maria ; Elfassy, Tali ; Swift, Samuel L. ; Yaffe, Kristine ; Singh-Manoux, Archana ; Zeki Al Hazzouri, Adina. / Relation between 20-year income volatility and brain health in midlife : The CARDIA study. In: Neurology. 2019 ; Vol. 93, No. 20. pp. e1890-e1899.
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