Relapsing polychondritis, chronic hepatitis C virus infection, and mixed cryoglobulemia

Ivonne Herrera, Ronald Concha, Enrique G. Molina, Eugene R. Schiff, Roy D. Altman

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


Objective Review of relapsing polychondritis (RP) and its association to chronic hepatitis C virus (HCV) infection and mixed cryoglobulinemia. Methods A case of RP associated with HCV infection is reported. The English language medical and scientific literature was reviewed for RP, hepatitis C, and its relation to other connective tissue diseases from February 1966 to January 2003 using MEDLINE. Results RP is an uncommon, multisystem disease of unknown etiology characterized by recurrent inflammation of cartilaginous and related tissues, being associated with other diseases in 30% to 35% of cases. HCV infection is a systemic illness with a propensity to trigger or exacerbate autoimmune disorders: eg, essential mixed cryoglobulinemia, membranoproliferative glomerulonephritis, and leukocytoclastic and systemic vasculitis. We could find no previous report of an association between RP with HCV and mixed cryoglobulinemia. Treatment with interferon gamma and ribavirin (IR) not only induced an undetectable viral load, but also resolved symptoms of RP. Conclusions We report a patient with RP, HCV, and mixed cryoglobulinemia. It is unknown if there is a cause-effect or chance relationship. Treatment with IR improved the symptoms of RP. It is not known whether the effects of IR were directly on the RP or suppressed RP indirectly through the actions on the viral load or active hepatitis.

Original languageEnglish (US)
Pages (from-to)388-403
Number of pages16
JournalSeminars in Arthritis and Rheumatism
Issue number6
StatePublished - Jun 2004


  • cartilage
  • hepatitis C virus
  • mixed cryoglobulinemia
  • Relapsing polychondritis

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine
  • Orthopedics and Sports Medicine
  • Rheumatology


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