Relapsing and remitting human immunodeficiency virus—associated leukoencephalomyelopathy

Joseph R. Berger, Carlo Tornatore, Eugene O. Major, Jocelyn Bruce, Paul Shapshak, Masaru Yoshioka, Sydney Houff, William Sheremata, Gerald F. Horton, Howard Landy

Research output: Contribution to journalArticlepeer-review

53 Scopus citations


We describe a 33-year-old homosexual man with a steroid-responsive, remitting and relapsing leukoencephalopathy associated with recent human immunodeficiency virus type 1 (HIV-1) seroconversion. Biopsy of a parieto-occipital lesion revealed demyelination and astrogliosis with focal necrosis. Detailed investigations demonstrated no pathogens in the brain other than HIV-1. This patient illustrates that a neurological disorder clinically indistinguishable from multiple sclerosis may be the presenting manifestation of HIV-1 infection and may occur in the absence of clinically significant immunosuppression.

Original languageEnglish (US)
Pages (from-to)34-38
Number of pages5
JournalAnnals of neurology
Issue number1
StatePublished - Jan 1992

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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