Relapsing and remitting human immunodeficiency virus—associated leukoencephalomyelopathy

Joseph R. Berger; Carlo Tornatore; Eugene O. Major; Jocelyn Bruce; Paul Shapshak; Masaru Yoshioka; Sydney Houff; William Sheremata; Gerald F. Horton; Howard Landy

doi:10.1002/ana.410310107

Relapsing and remitting human immunodeficiency virus—associated leukoencephalomyelopathy

Joseph R. Berger, Carlo Tornatore, Eugene O. Major, Jocelyn Bruce, Paul Shapshak, Masaru Yoshioka, Sydney Houff, William Sheremata, Gerald F. Horton, Howard Landy

Research output: Contribution to journal › Article › peer-review

53 Scopus citations

Abstract

We describe a 33-year-old homosexual man with a steroid-responsive, remitting and relapsing leukoencephalopathy associated with recent human immunodeficiency virus type 1 (HIV-1) seroconversion. Biopsy of a parieto-occipital lesion revealed demyelination and astrogliosis with focal necrosis. Detailed investigations demonstrated no pathogens in the brain other than HIV-1. This patient illustrates that a neurological disorder clinically indistinguishable from multiple sclerosis may be the presenting manifestation of HIV-1 infection and may occur in the absence of clinically significant immunosuppression.

Original language	English (US)
Pages (from-to)	34-38
Number of pages	5
Journal	Annals of neurology
Volume	31
Issue number	1
DOIs	https://doi.org/10.1002/ana.410310107
State	Published - Jan 1992

ASJC Scopus subject areas

Neurology
Clinical Neurology

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Relapsing and remitting human immunodeficiency virus—associated leukoencephalomyelopathy. / Berger, Joseph R.; Tornatore, Carlo; Major, Eugene O.; Bruce, Jocelyn; Shapshak, Paul; Yoshioka, Masaru; Houff, Sydney; Sheremata, William; Horton, Gerald F.; Landy, Howard.

In: Annals of neurology, Vol. 31, No. 1, 01.1992, p. 34-38.

Research output: Contribution to journal › Article › peer-review

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AU - Sheremata, William

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Relapsing and remitting human immunodeficiency virus—associated leukoencephalomyelopathy

Abstract

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