Relapsing and remitting human immunodeficiency virus-associated leukoencephalomyelopathy

Joseph R. Berger, Carlo Tornatore, Eugene O. Major, Jocelyn Bruce, Paul Shapshak, Masaru Yoshioka, Sydney Houff, William Sheremata, Gerald F. Horton, Howard Landy

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

We describe a 33-year-old homosexual man with a steroid-responsive, remitting and relapsing leukoencephalopathy associated with recent human immunodeficiency virus type 1 (HIV-1) seroconversion. Biopsy of a parieto-occipital lesion revealed demyelination and astrogliosis with focal necrosis. Detailed investigations demonstrated no pathogens in the brain other than HIV-1. This patient illustrates that a neurological disorder clinically indistinguishable from multiple sclerosis may be the presenting manifestation of HIV-1 infection and may occur in the absence of clinically significant immunosuppression.

Original languageEnglish
Pages (from-to)34-38
Number of pages5
JournalAnnals of Neurology
Volume31
Issue number1
StatePublished - Jan 1 1992

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HIV-1
HIV
Leukoencephalopathies
Demyelinating Diseases
Virus Diseases
Nervous System Diseases
Immunosuppression
Multiple Sclerosis
Necrosis
Steroids
Biopsy
Brain
Sexual Minorities
Seroconversion

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Berger, J. R., Tornatore, C., Major, E. O., Bruce, J., Shapshak, P., Yoshioka, M., ... Landy, H. (1992). Relapsing and remitting human immunodeficiency virus-associated leukoencephalomyelopathy. Annals of Neurology, 31(1), 34-38.

Relapsing and remitting human immunodeficiency virus-associated leukoencephalomyelopathy. / Berger, Joseph R.; Tornatore, Carlo; Major, Eugene O.; Bruce, Jocelyn; Shapshak, Paul; Yoshioka, Masaru; Houff, Sydney; Sheremata, William; Horton, Gerald F.; Landy, Howard.

In: Annals of Neurology, Vol. 31, No. 1, 01.01.1992, p. 34-38.

Research output: Contribution to journalArticle

Berger, JR, Tornatore, C, Major, EO, Bruce, J, Shapshak, P, Yoshioka, M, Houff, S, Sheremata, W, Horton, GF & Landy, H 1992, 'Relapsing and remitting human immunodeficiency virus-associated leukoencephalomyelopathy', Annals of Neurology, vol. 31, no. 1, pp. 34-38.
Berger JR, Tornatore C, Major EO, Bruce J, Shapshak P, Yoshioka M et al. Relapsing and remitting human immunodeficiency virus-associated leukoencephalomyelopathy. Annals of Neurology. 1992 Jan 1;31(1):34-38.
Berger, Joseph R. ; Tornatore, Carlo ; Major, Eugene O. ; Bruce, Jocelyn ; Shapshak, Paul ; Yoshioka, Masaru ; Houff, Sydney ; Sheremata, William ; Horton, Gerald F. ; Landy, Howard. / Relapsing and remitting human immunodeficiency virus-associated leukoencephalomyelopathy. In: Annals of Neurology. 1992 ; Vol. 31, No. 1. pp. 34-38.
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