relA overcomes the slow growth of cca mutants

Murray P. Deutscher, Peter Setlow, John Foulds

Research output: Contribution to journalLetter

9 Scopus citations

Abstract

The slow growth of stringent cca mutants can be overcome by mutation at the relA locus. The elevated basal ppGpp to GTP ratio associated with the slow growth is also reversed by a relA mutation. Mutation at a second locus (or loci), distinct from relA or cca, which decreases the amount of defective tRNA, also increases the growth rate of stringent cca cells. The possibility of deleterious effects of tRNA-C-C in stringent cells is discussed.

Original languageEnglish (US)
Pages (from-to)1095-1100
Number of pages6
JournalJournal of molecular biology
Volume117
Issue number4
DOIs
StatePublished - Dec 25 1977

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ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology

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