relA overcomes the slow growth of cca mutants

Murray P. Deutscher, Peter Setlow, John Foulds

Research output: Contribution to journalLetterpeer-review

9 Scopus citations


The slow growth of stringent cca mutants can be overcome by mutation at the relA locus. The elevated basal ppGpp to GTP ratio associated with the slow growth is also reversed by a relA mutation. Mutation at a second locus (or loci), distinct from relA or cca, which decreases the amount of defective tRNA, also increases the growth rate of stringent cca cells. The possibility of deleterious effects of tRNA-C-C in stringent cells is discussed.

Original languageEnglish (US)
Pages (from-to)1095-1100
Number of pages6
JournalJournal of molecular biology
Issue number4
StatePublished - Dec 25 1977

ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology


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