Reinnervation of the allograft larynx in the rat laryngeal transplant model

DONALD T. WEED, CHEERASOOK CHONGKOLWATANA, YUJI KAWAMURA, BRIAN B. BURKEY, JAMES L. NETTERVILLE, ROBERT H. OSSOFF, DAVID L. ZEALEAR

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

The rat model for a vascularized laryngeal allograft is duplicated with significant technical modifications. We report the addition of unilateral host-to-allograft recurrent laryngeal nerve anastomosis to this model. Long- term survival experiments determine the feasibility of reinnervation studies of the allograft larynx with this new model. A total of 59 transplants have been performed on histocompatible Munich Wistar rats, 36 with attempted unilateral allograft reinnervation. Because of the initially high operative mortality rates, additions and modifications of the original technique resulting in reproducibly enhanced survival are detailed. Factors critical to the functional study of this model with regard to reinnervation are elucidated. Preliminary data on allograft reinnervation are reported as confirmed by videodocumentation of vocal told mobility, evoked and spontaneous electromyography, and glycogen-depletion studies.

Original languageEnglish (US)
Pages (from-to)517-529
Number of pages13
JournalOtolaryngology - Head and Neck Surgery (United States)
Volume113
Issue number5
DOIs
StatePublished - 1995

ASJC Scopus subject areas

  • Surgery
  • Otorhinolaryngology

Fingerprint Dive into the research topics of 'Reinnervation of the allograft larynx in the rat laryngeal transplant model'. Together they form a unique fingerprint.

  • Cite this

    WEED, DONALD. T., CHONGKOLWATANA, CHEERASOOK., KAWAMURA, YUJI., BURKEY, BRIAN. B., NETTERVILLE, JAMES. L., OSSOFF, ROBERT. H., & ZEALEAR, DAVID. L. (1995). Reinnervation of the allograft larynx in the rat laryngeal transplant model. Otolaryngology - Head and Neck Surgery (United States), 113(5), 517-529. https://doi.org/10.1016/S0194-5998(95)70042-0