TY - JOUR
T1 - Reinnervation of the allograft larynx in the rat laryngeal transplant model
AU - WEED, DONALD T.
AU - CHONGKOLWATANA, CHEERASOOK
AU - KAWAMURA, YUJI
AU - BURKEY, BRIAN B.
AU - NETTERVILLE, JAMES L.
AU - OSSOFF, ROBERT H.
AU - ZEALEAR, DAVID L.
N1 - Funding Information:
Supported by the Resident Research Fund, Department of Otolaryngology, Vanderbilt University Medical Center, Nashville, Tenn., and National Institutes of Health grant 2 RO1 DCO1149.
PY - 1995
Y1 - 1995
N2 - The rat model for a vascularized laryngeal allograft is duplicated with significant technical modifications. We report the addition of unilateral host-to-allograft recurrent laryngeal nerve anastomosis to this model. Long- term survival experiments determine the feasibility of reinnervation studies of the allograft larynx with this new model. A total of 59 transplants have been performed on histocompatible Munich Wistar rats, 36 with attempted unilateral allograft reinnervation. Because of the initially high operative mortality rates, additions and modifications of the original technique resulting in reproducibly enhanced survival are detailed. Factors critical to the functional study of this model with regard to reinnervation are elucidated. Preliminary data on allograft reinnervation are reported as confirmed by videodocumentation of vocal told mobility, evoked and spontaneous electromyography, and glycogen-depletion studies.
AB - The rat model for a vascularized laryngeal allograft is duplicated with significant technical modifications. We report the addition of unilateral host-to-allograft recurrent laryngeal nerve anastomosis to this model. Long- term survival experiments determine the feasibility of reinnervation studies of the allograft larynx with this new model. A total of 59 transplants have been performed on histocompatible Munich Wistar rats, 36 with attempted unilateral allograft reinnervation. Because of the initially high operative mortality rates, additions and modifications of the original technique resulting in reproducibly enhanced survival are detailed. Factors critical to the functional study of this model with regard to reinnervation are elucidated. Preliminary data on allograft reinnervation are reported as confirmed by videodocumentation of vocal told mobility, evoked and spontaneous electromyography, and glycogen-depletion studies.
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U2 - 10.1016/S0194-5998(95)70042-0
DO - 10.1016/S0194-5998(95)70042-0
M3 - Article
C2 - 7478641
AN - SCOPUS:0028817980
VL - 113
SP - 517
EP - 529
JO - Otolaryngology - Head and Neck Surgery (United States)
JF - Otolaryngology - Head and Neck Surgery (United States)
SN - 0194-5998
IS - 5
ER -