Reinnervation of the allograft larynx in the rat laryngeal transplant model

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The rat model for a vascularized laryngeal allograft is duplicated with significant technical modifications. We report the addition of unilateral host-to-allograft recurrent laryngeal nerve anastomosis to this model. Long- term survival experiments determine the feasibility of reinnervation studies of the allograft larynx with this new model. A total of 59 transplants have been performed on histocompatible Munich Wistar rats, 36 with attempted unilateral allograft reinnervation. Because of the initially high operative mortality rates, additions and modifications of the original technique resulting in reproducibly enhanced survival are detailed. Factors critical to the functional study of this model with regard to reinnervation are elucidated. Preliminary data on allograft reinnervation are reported as confirmed by videodocumentation of vocal told mobility, evoked and spontaneous electromyography, and glycogen-depletion studies.

Original languageEnglish
Pages (from-to)517-529
Number of pages13
JournalOtolaryngology - Head and Neck Surgery
Volume113
Issue number5
DOIs
StatePublished - Nov 23 1995
Externally publishedYes

Fingerprint

Larynx
Allografts
Transplants
Recurrent Laryngeal Nerve
Feasibility Studies
Electromyography
Glycogen
Wistar Rats
Mortality

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Reinnervation of the allograft larynx in the rat laryngeal transplant model. / Weed, Donald.

In: Otolaryngology - Head and Neck Surgery, Vol. 113, No. 5, 23.11.1995, p. 517-529.

Research output: Contribution to journalArticle

@article{9a520c6db1bb4b03a369fa934f8e7829,
title = "Reinnervation of the allograft larynx in the rat laryngeal transplant model",
abstract = "The rat model for a vascularized laryngeal allograft is duplicated with significant technical modifications. We report the addition of unilateral host-to-allograft recurrent laryngeal nerve anastomosis to this model. Long- term survival experiments determine the feasibility of reinnervation studies of the allograft larynx with this new model. A total of 59 transplants have been performed on histocompatible Munich Wistar rats, 36 with attempted unilateral allograft reinnervation. Because of the initially high operative mortality rates, additions and modifications of the original technique resulting in reproducibly enhanced survival are detailed. Factors critical to the functional study of this model with regard to reinnervation are elucidated. Preliminary data on allograft reinnervation are reported as confirmed by videodocumentation of vocal told mobility, evoked and spontaneous electromyography, and glycogen-depletion studies.",
author = "Donald Weed",
year = "1995",
month = "11",
day = "23",
doi = "10.1016/S0194-5998(95)70042-0",
language = "English",
volume = "113",
pages = "517--529",
journal = "Otolaryngology - Head and Neck Surgery (United States)",
issn = "0194-5998",
publisher = "Mosby Inc.",
number = "5",

}

TY - JOUR

T1 - Reinnervation of the allograft larynx in the rat laryngeal transplant model

AU - Weed, Donald

PY - 1995/11/23

Y1 - 1995/11/23

N2 - The rat model for a vascularized laryngeal allograft is duplicated with significant technical modifications. We report the addition of unilateral host-to-allograft recurrent laryngeal nerve anastomosis to this model. Long- term survival experiments determine the feasibility of reinnervation studies of the allograft larynx with this new model. A total of 59 transplants have been performed on histocompatible Munich Wistar rats, 36 with attempted unilateral allograft reinnervation. Because of the initially high operative mortality rates, additions and modifications of the original technique resulting in reproducibly enhanced survival are detailed. Factors critical to the functional study of this model with regard to reinnervation are elucidated. Preliminary data on allograft reinnervation are reported as confirmed by videodocumentation of vocal told mobility, evoked and spontaneous electromyography, and glycogen-depletion studies.

AB - The rat model for a vascularized laryngeal allograft is duplicated with significant technical modifications. We report the addition of unilateral host-to-allograft recurrent laryngeal nerve anastomosis to this model. Long- term survival experiments determine the feasibility of reinnervation studies of the allograft larynx with this new model. A total of 59 transplants have been performed on histocompatible Munich Wistar rats, 36 with attempted unilateral allograft reinnervation. Because of the initially high operative mortality rates, additions and modifications of the original technique resulting in reproducibly enhanced survival are detailed. Factors critical to the functional study of this model with regard to reinnervation are elucidated. Preliminary data on allograft reinnervation are reported as confirmed by videodocumentation of vocal told mobility, evoked and spontaneous electromyography, and glycogen-depletion studies.

UR - http://www.scopus.com/inward/record.url?scp=0028817980&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028817980&partnerID=8YFLogxK

U2 - 10.1016/S0194-5998(95)70042-0

DO - 10.1016/S0194-5998(95)70042-0

M3 - Article

C2 - 7478641

AN - SCOPUS:0028817980

VL - 113

SP - 517

EP - 529

JO - Otolaryngology - Head and Neck Surgery (United States)

JF - Otolaryngology - Head and Neck Surgery (United States)

SN - 0194-5998

IS - 5

ER -