Regulatory roles of natural antisense transcripts

Research output: Contribution to journalArticle

434 Citations (Scopus)

Abstract

Mammalian genomes encode numerous natural antisense transcripts, but the function of these transcripts is not well understood. Functional validation studies indicate that antisense transcripts are not a uniform group of regulatory RNAs but instead belong to multiple categories with some common features. Recent evidence indicates that antisense transcripts are frequently functional and use diverse transcriptional and post-transcriptional gene regulatory mechanisms to carry out a wide variety of biological roles.

Original languageEnglish
Pages (from-to)637-643
Number of pages7
JournalNature Reviews Molecular Cell Biology
Volume10
Issue number9
DOIs
StatePublished - Sep 1 2009
Externally publishedYes

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Validation Studies
Regulator Genes
Genome
RNA

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

Cite this

Regulatory roles of natural antisense transcripts. / Faghihi, Mohammad A; Wahlestedt, Claes R.

In: Nature Reviews Molecular Cell Biology, Vol. 10, No. 9, 01.09.2009, p. 637-643.

Research output: Contribution to journalArticle

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