Regulatory roles of natural antisense transcripts

Research output: Contribution to journalReview article

455 Scopus citations

Abstract

Mammalian genomes encode numerous natural antisense transcripts, but the function of these transcripts is not well understood. Functional validation studies indicate that antisense transcripts are not a uniform group of regulatory RNAs but instead belong to multiple categories with some common features. Recent evidence indicates that antisense transcripts are frequently functional and use diverse transcriptional and post-transcriptional gene regulatory mechanisms to carry out a wide variety of biological roles.

Original languageEnglish (US)
Pages (from-to)637-643
Number of pages7
JournalNature Reviews Molecular Cell Biology
Volume10
Issue number9
DOIs
StatePublished - Sep 1 2009
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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