Regulatory immunotherapy in bone marrow transplantation

Vanessa Morales-Tirado, Wioleta Luszczek, Marié Van Der Merwe, Asha Pillai

Research output: Contribution to journalReview article

1 Scopus citations

Abstract

Every year individuals receive hematopoietic stem cell transplantation (HSCT) to eradicate malignant and nonmalignant disease. The immunobiology of allotransplantation is an area of ongoing discovery, from the recipient's conditioning treatment prior to the transplant to the donor cell populations responsible for engraftment, graft-versus-host disease, and graft-versus-tumor effect. In this review, we focus on donor-type immunoregulatory T cells, namely, natural killer T cells (NKT) and regulatory T cells (Treg), and their current and potential roles in tolerance induction after allogeneic HSCT.

Original languageEnglish (US)
Pages (from-to)2620-2634
Number of pages15
JournalTheScientificWorldJournal
Volume11
DOIs
StatePublished - 2011

Keywords

  • Allogeneic transplantation
  • GVHD
  • GVT
  • NKT
  • immunoregulation
  • regulatory T cells
  • transplant tolerance

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Environmental Science(all)

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