Abstract
Every year individuals receive hematopoietic stem cell transplantation (HSCT) to eradicate malignant and nonmalignant disease. The immunobiology of allotransplantation is an area of ongoing discovery, from the recipient's conditioning treatment prior to the transplant to the donor cell populations responsible for engraftment, graft-versus-host disease, and graft-versus-tumor effect. In this review, we focus on donor-type immunoregulatory T cells, namely, natural killer T cells (NKT) and regulatory T cells (Treg), and their current and potential roles in tolerance induction after allogeneic HSCT.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 2620-2634 |
| Number of pages | 15 |
| Journal | TheScientificWorldJournal |
| Volume | 11 |
| DOIs | |
| State | Published - 2011 |
Keywords
- Allogeneic transplantation
- GVHD
- GVT
- NKT
- immunoregulation
- regulatory T cells
- transplant tolerance
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Environmental Science(all)
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Cite this
Morales-Tirado, V., Luszczek, W., Van Der Merwe, M., & Pillai, A. (2011). Regulatory immunotherapy in bone marrow transplantation. TheScientificWorldJournal, 11, 2620-2634. https://doi.org/10.1100/2011/768948