Regulatory immunotherapy in bone marrow transplantation

Vanessa Morales-Tirado; Wioleta Luszczek; Marié Van Der Merwe; Asha Pillai

doi:10.1100/2011/768948

Regulatory immunotherapy in bone marrow transplantation

Vanessa Morales-Tirado, Wioleta Luszczek, Marié Van Der Merwe, Asha Pillai

Research output: Contribution to journal › Review article › peer-review

1 Scopus citations

Abstract

Every year individuals receive hematopoietic stem cell transplantation (HSCT) to eradicate malignant and nonmalignant disease. The immunobiology of allotransplantation is an area of ongoing discovery, from the recipient's conditioning treatment prior to the transplant to the donor cell populations responsible for engraftment, graft-versus-host disease, and graft-versus-tumor effect. In this review, we focus on donor-type immunoregulatory T cells, namely, natural killer T cells (NKT) and regulatory T cells (Treg), and their current and potential roles in tolerance induction after allogeneic HSCT.

Original language	English (US)
Pages (from-to)	2620-2634
Number of pages	15
Journal	TheScientificWorldJournal
Volume	11
DOIs	https://doi.org/10.1100/2011/768948
State	Published - 2011
Externally published	Yes

Keywords

Allogeneic transplantation
GVHD
GVT
NKT
immunoregulation
regulatory T cells
transplant tolerance

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Environmental Science(all)

Access to Document

10.1100/2011/768948

Cite this

@article{9acc11df0e50493d9f9e5ea2160e4e9f,

title = "Regulatory immunotherapy in bone marrow transplantation",

abstract = "Every year individuals receive hematopoietic stem cell transplantation (HSCT) to eradicate malignant and nonmalignant disease. The immunobiology of allotransplantation is an area of ongoing discovery, from the recipient's conditioning treatment prior to the transplant to the donor cell populations responsible for engraftment, graft-versus-host disease, and graft-versus-tumor effect. In this review, we focus on donor-type immunoregulatory T cells, namely, natural killer T cells (NKT) and regulatory T cells (Treg), and their current and potential roles in tolerance induction after allogeneic HSCT.",

keywords = "Allogeneic transplantation, GVHD, GVT, NKT, immunoregulation, regulatory T cells, transplant tolerance",

author = "Vanessa Morales-Tirado and Wioleta Luszczek and {Van Der Merwe}, Mari{\'e} and Asha Pillai",

year = "2011",

doi = "10.1100/2011/768948",

language = "English (US)",

volume = "11",

pages = "2620--2634",

journal = "The Scientific World Journal",

issn = "1537-744X",

publisher = "Hindawi Publishing Corporation",

}

TY - JOUR

T1 - Regulatory immunotherapy in bone marrow transplantation

AU - Morales-Tirado, Vanessa

AU - Luszczek, Wioleta

AU - Van Der Merwe, Marié

AU - Pillai, Asha

PY - 2011

Y1 - 2011

N2 - Every year individuals receive hematopoietic stem cell transplantation (HSCT) to eradicate malignant and nonmalignant disease. The immunobiology of allotransplantation is an area of ongoing discovery, from the recipient's conditioning treatment prior to the transplant to the donor cell populations responsible for engraftment, graft-versus-host disease, and graft-versus-tumor effect. In this review, we focus on donor-type immunoregulatory T cells, namely, natural killer T cells (NKT) and regulatory T cells (Treg), and their current and potential roles in tolerance induction after allogeneic HSCT.

AB - Every year individuals receive hematopoietic stem cell transplantation (HSCT) to eradicate malignant and nonmalignant disease. The immunobiology of allotransplantation is an area of ongoing discovery, from the recipient's conditioning treatment prior to the transplant to the donor cell populations responsible for engraftment, graft-versus-host disease, and graft-versus-tumor effect. In this review, we focus on donor-type immunoregulatory T cells, namely, natural killer T cells (NKT) and regulatory T cells (Treg), and their current and potential roles in tolerance induction after allogeneic HSCT.

KW - Allogeneic transplantation

KW - GVHD

KW - GVT

KW - NKT

KW - immunoregulation

KW - regulatory T cells

KW - transplant tolerance

UR - http://www.scopus.com/inward/record.url?scp=84855573839&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84855573839&partnerID=8YFLogxK

U2 - 10.1100/2011/768948

DO - 10.1100/2011/768948

M3 - Review article

C2 - 22262950

AN - SCOPUS:84855573839

VL - 11

SP - 2620

EP - 2634

JO - The Scientific World Journal

JF - The Scientific World Journal

SN - 1537-744X

ER -

Regulatory immunotherapy in bone marrow transplantation

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this