TY - JOUR
T1 - Regulation of transcription by long noncoding RNAs
AU - Bonasio, Roberto
AU - Shiekhattar, Ramin
N1 - Publisher Copyright:
© 2014 by Annual Reviews. All rights reserved.
Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 2014/11/23
Y1 - 2014/11/23
N2 - Over the past decade there has been a greater understanding of genomic complexity in eukaryotes ushered in by the immense technological advances in high-throughput sequencing of DNA and its corresponding RNA transcripts. This has resulted in the realization that beyond protein-coding genes, there are a large number of transcripts that do not encode for proteins and, therefore, may perform their function through RNA sequences and/or through secondary and tertiary structural determinants. This review is focused on the latest findings on a class of noncoding RNAs that are relatively large (>200 nucleotides), display nuclear localization, and use different strategies to regulate transcription. These are exciting times for discovering the biological scope and the mechanism of action for these RNA molecules, which have roles in dosage compensation, imprinting, enhancer function, and transcriptional regulation, with a great impact on development and disease.
AB - Over the past decade there has been a greater understanding of genomic complexity in eukaryotes ushered in by the immense technological advances in high-throughput sequencing of DNA and its corresponding RNA transcripts. This has resulted in the realization that beyond protein-coding genes, there are a large number of transcripts that do not encode for proteins and, therefore, may perform their function through RNA sequences and/or through secondary and tertiary structural determinants. This review is focused on the latest findings on a class of noncoding RNAs that are relatively large (>200 nucleotides), display nuclear localization, and use different strategies to regulate transcription. These are exciting times for discovering the biological scope and the mechanism of action for these RNA molecules, which have roles in dosage compensation, imprinting, enhancer function, and transcriptional regulation, with a great impact on development and disease.
KW - RNA polymerase II
KW - chromatin
KW - chromatin-modifying complexes
KW - enhancers
KW - imprinting
KW - transcriptional silencing
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U2 - 10.1146/annurev-genet-120213-092323
DO - 10.1146/annurev-genet-120213-092323
M3 - Article
C2 - 25251851
AN - SCOPUS:84913532607
VL - 48
SP - 433
EP - 455
JO - Annual Review of Genetics
JF - Annual Review of Genetics
SN - 0066-4197
ER -