Regulation of the map kinase cascade

M. H. Cobb, S. Xu, J. E. Hepler, M. Hutchison, J. Frost, David J Robbins

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

The MAP kinase cascade is regulated by many hormones and growth factors and its activation leads to changes in properties of cytoplasmic, membrane-associated, and nuclear proteins. The MAP kinases themselves are activated by MEKS. MEKs lie at a point of convergence for multiple upstream signals, mediated by distinct protein kinases, Raf, MEK kinase, and Mos, all of which have MEK kinase activity. Additional inputs that stimulate the MAP kinase pathway are the activation of protein kinase C and the yeast protein kinase STE20. Mechanisms of regulation of some of the upstream components of this cascade have not yet been fully elucidated.

Original languageEnglish
Pages (from-to)253-256
Number of pages4
JournalCellular and Molecular Biology Research
Volume40
Issue number3
StatePublished - Jan 1 1994
Externally publishedYes

Fingerprint

MAP Kinase Kinase Kinases
Protein Kinases
Phosphotransferases
raf Kinases
Fungal Proteins
MAP Kinase Signaling System
Mitogen-Activated Protein Kinase Kinases
Nuclear Proteins
Chemical activation
Protein Kinase C
Intercellular Signaling Peptides and Proteins
Membrane Proteins
Hormones
Cell Membrane

Keywords

  • Hormone action
  • MAP kinase
  • Protein kinases

ASJC Scopus subject areas

  • Cell Biology
  • Clinical Biochemistry
  • Molecular Biology

Cite this

Cobb, M. H., Xu, S., Hepler, J. E., Hutchison, M., Frost, J., & Robbins, D. J. (1994). Regulation of the map kinase cascade. Cellular and Molecular Biology Research, 40(3), 253-256.

Regulation of the map kinase cascade. / Cobb, M. H.; Xu, S.; Hepler, J. E.; Hutchison, M.; Frost, J.; Robbins, David J.

In: Cellular and Molecular Biology Research, Vol. 40, No. 3, 01.01.1994, p. 253-256.

Research output: Contribution to journalArticle

Cobb, MH, Xu, S, Hepler, JE, Hutchison, M, Frost, J & Robbins, DJ 1994, 'Regulation of the map kinase cascade', Cellular and Molecular Biology Research, vol. 40, no. 3, pp. 253-256.
Cobb MH, Xu S, Hepler JE, Hutchison M, Frost J, Robbins DJ. Regulation of the map kinase cascade. Cellular and Molecular Biology Research. 1994 Jan 1;40(3):253-256.
Cobb, M. H. ; Xu, S. ; Hepler, J. E. ; Hutchison, M. ; Frost, J. ; Robbins, David J. / Regulation of the map kinase cascade. In: Cellular and Molecular Biology Research. 1994 ; Vol. 40, No. 3. pp. 253-256.
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