Regulation of the Cdk inhibitor p27 and its deregulation in cancer

J. Slingerland, M. Pagano

Research output: Contribution to journalArticle

608 Scopus citations

Abstract

p27 is a cell cycle inhibitor whose cellular abundance increases in response to many antimitogenic stimuli. In this review, we summarize the current knowledge on p27 function and its regulation by synthesis and by ubiquitin-mediated degradation. Importantly, p27 degradation is enhanced in many aggressive human tumors. The frequency with which this is observed suggests that loss of p27 may confer a growth advantage to these cancers. From a practical point of view, immunodetection of p27 in tumors may prove to be useful in the assessment of prognosis and may ultimately influence the therapy of this disease. (C) 2000 Wiley-Liss, Inc.

Original languageEnglish (US)
Pages (from-to)10-17
Number of pages8
JournalJournal of Cellular Physiology
Volume183
Issue number1
DOIs
StatePublished - Mar 14 2000
Externally publishedYes

ASJC Scopus subject areas

  • Physiology
  • Clinical Biochemistry
  • Cell Biology

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